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- PMID: 31795353
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Article: Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus
Title | Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus |
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Authors | |
Keywords | systemic lupus erythematosus (SLE) autoreactive B cells age-associated B cells (ABCs) regulatory B cells (Bregs) |
Issue Date | 2019 |
Publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms |
Citation | International Journal of Molecular Sciences, 2019, v. 20 n. 23, article no. 6021 How to Cite? |
Abstract | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by excessive autoantibody production and multi-organ involvement. Although the etiology of SLE still remains unclear, recent studies have characterized several pathogenic B cell subsets and regulatory B cell subsets involved in the pathogenesis of SLE. Among pathogenic B cell subsets, age-associated B cells (ABCs) are a newly identified subset of autoreactive B cells with T-bet-dependent transcriptional programs and unique functional features in SLE. Accumulation of T-bet+ CD11c+ ABCs has been observed in SLE patients and lupus mouse models. In addition, innate-like B cells with the autoreactive B cell receptor (BCR) expression and long-lived plasma cells with persistent autoantibody production contribute to the development of SLE. Moreover, several regulatory B cell subsets with immune suppressive functions have been identified, while the impaired inhibitory effects of regulatory B cells have been indicated in SLE. Thus, further elucidation on the functional features of B cell subsets will provide new insights in understanding lupus pathogenesis and lead to novel therapeutic interventions in the treatment of SLE. |
Persistent Identifier | http://hdl.handle.net/10722/281908 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ma, K | - |
dc.contributor.author | Du, W | - |
dc.contributor.author | Wang, X | - |
dc.contributor.author | Yuan, S | - |
dc.contributor.author | Cai, X | - |
dc.contributor.author | Liu, D | - |
dc.contributor.author | Li, J | - |
dc.contributor.author | Lu, L | - |
dc.date.accessioned | 2020-04-03T07:23:29Z | - |
dc.date.available | 2020-04-03T07:23:29Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2019, v. 20 n. 23, article no. 6021 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/281908 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by excessive autoantibody production and multi-organ involvement. Although the etiology of SLE still remains unclear, recent studies have characterized several pathogenic B cell subsets and regulatory B cell subsets involved in the pathogenesis of SLE. Among pathogenic B cell subsets, age-associated B cells (ABCs) are a newly identified subset of autoreactive B cells with T-bet-dependent transcriptional programs and unique functional features in SLE. Accumulation of T-bet+ CD11c+ ABCs has been observed in SLE patients and lupus mouse models. In addition, innate-like B cells with the autoreactive B cell receptor (BCR) expression and long-lived plasma cells with persistent autoantibody production contribute to the development of SLE. Moreover, several regulatory B cell subsets with immune suppressive functions have been identified, while the impaired inhibitory effects of regulatory B cells have been indicated in SLE. Thus, further elucidation on the functional features of B cell subsets will provide new insights in understanding lupus pathogenesis and lead to novel therapeutic interventions in the treatment of SLE. | - |
dc.language | eng | - |
dc.publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | systemic lupus erythematosus (SLE) | - |
dc.subject | autoreactive B cells | - |
dc.subject | age-associated B cells (ABCs) | - |
dc.subject | regulatory B cells (Bregs) | - |
dc.title | Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus | - |
dc.type | Article | - |
dc.identifier.email | Ma, K: kongyang@hku.hk | - |
dc.identifier.email | Wang, X: xiaohuiwang@hku.hk | - |
dc.identifier.email | Lu, L: liweilu@hku.hk | - |
dc.identifier.authority | Wang, X=rp02664 | - |
dc.identifier.authority | Lu, L=rp00477 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/ijms20236021 | - |
dc.identifier.pmid | 31795353 | - |
dc.identifier.pmcid | PMC6929160 | - |
dc.identifier.scopus | eid_2-s2.0-85075879133 | - |
dc.identifier.hkuros | 309591 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 23 | - |
dc.identifier.spage | article no. 6021 | - |
dc.identifier.epage | article no. 6021 | - |
dc.identifier.isi | WOS:000504428300203 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1422-0067 | - |