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- Publisher Website: 10.1038/ncomms4039
- Scopus: eid_2-s2.0-84892714228
- PMID: 24423728
- WOS: WOS:000331083800022
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Article: Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages
Title | Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages |
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Authors | |
Issue Date | 2014 |
Citation | Nature Communications, 2014, v. 5 How to Cite? |
Abstract | Tuned and distinct responses of macrophages and dendritic cells to Toll-like receptor 4 (TLR4) activation induced by lipopolysaccharide (LPS) underpin the balance between innate and adaptive immunity. However, the molecule(s) that confer these cell-type-specific LPS-induced effects remain poorly understood. Here we report that the integrin αM(CD11b) positively regulates LPS-induced signalling pathways selectively in myeloid dendritic cells but not in macrophages. In dendritic cells, which express lower levels of CD14 and TLR4 than macrophages, CD11b promotes MyD88-dependent and MyD88-independent signalling pathways. In particular, in dendritic cells CD11b facilitates LPS-induced TLR4 endocytosis and is required for the subsequent signalling in the endosomes. Consistent with this, CD11b deficiency dampens dendritic cell-mediated TLR4-triggered responses in vivo leading to impaired T-cell activation. Thus, by modulating the trafficking and signalling functions of TLR4 in a cell-type-specific manner CD11b fine tunes the balance between adaptive and innate immune responses initiated by LPS. © 2014 Macmillan Publishers Limited. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/279667 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ling, Guang Sheng | - |
dc.contributor.author | Bennett, Jason | - |
dc.contributor.author | Woollard, Kevin J. | - |
dc.contributor.author | Szajna, Marta | - |
dc.contributor.author | Fossati-Jimack, Liliane | - |
dc.contributor.author | Taylor, Philip R. | - |
dc.contributor.author | Scott, Diane | - |
dc.contributor.author | Franzoso, Guido | - |
dc.contributor.author | Cook, H. Terence | - |
dc.contributor.author | Botto, Marina | - |
dc.date.accessioned | 2019-11-27T08:09:43Z | - |
dc.date.available | 2019-11-27T08:09:43Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Nature Communications, 2014, v. 5 | - |
dc.identifier.uri | http://hdl.handle.net/10722/279667 | - |
dc.description.abstract | Tuned and distinct responses of macrophages and dendritic cells to Toll-like receptor 4 (TLR4) activation induced by lipopolysaccharide (LPS) underpin the balance between innate and adaptive immunity. However, the molecule(s) that confer these cell-type-specific LPS-induced effects remain poorly understood. Here we report that the integrin αM(CD11b) positively regulates LPS-induced signalling pathways selectively in myeloid dendritic cells but not in macrophages. In dendritic cells, which express lower levels of CD14 and TLR4 than macrophages, CD11b promotes MyD88-dependent and MyD88-independent signalling pathways. In particular, in dendritic cells CD11b facilitates LPS-induced TLR4 endocytosis and is required for the subsequent signalling in the endosomes. Consistent with this, CD11b deficiency dampens dendritic cell-mediated TLR4-triggered responses in vivo leading to impaired T-cell activation. Thus, by modulating the trafficking and signalling functions of TLR4 in a cell-type-specific manner CD11b fine tunes the balance between adaptive and innate immune responses initiated by LPS. © 2014 Macmillan Publishers Limited. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/ncomms4039 | - |
dc.identifier.pmid | 24423728 | - |
dc.identifier.scopus | eid_2-s2.0-84892714228 | - |
dc.identifier.volume | 5 | - |
dc.identifier.spage | null | - |
dc.identifier.epage | null | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.isi | WOS:000331083800022 | - |
dc.identifier.issnl | 2041-1723 | - |