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Article: Acquisition of multipotent and migratory neural crest cells in vertebrate evolution

TitleAcquisition of multipotent and migratory neural crest cells in vertebrate evolution
Authors
Issue Date2019
PublisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/gde
Citation
Current Opinion in Genetics & Development, 2019, v. 57, p. 84-90 How to Cite?
AbstractThe emergence of multipotent and migratory neural crest (NC) cells defines a key evolutionary transition from invertebrates to vertebrates. Studies in vertebrates have identified a complex gene regulatory network that governs sequential stages of NC ontogeny. Comparative analysis has revealed extensive conservation of the overall architecture of the NC gene regulatory network between jawless and jawed vertebrates. Among invertebrates, urochordates express putative NC gene homologs in the neural plate border region, but these NC-like cells do not have migratory capacity, whereas cephalochordates contain no NC cells but its genome contains most homologs of vertebrate NC genes. Whether the absence of migratory NC cells in invertebrates is due to differences in enhancer elements or an intrinsic limitation in potency remains unclear. We provide a brief overview of mechanisms that might explain how ancestral NC-like cells acquired the multipotency and migratory capacity seen in vertebrates.
Persistent Identifierhttp://hdl.handle.net/10722/276240
ISSN
2017 Impact Factor: 4.995
2015 SCImago Journal Rankings: 5.654

 

DC FieldValueLanguage
dc.contributor.authorCheung, M-
dc.contributor.authorTai, A-
dc.contributor.authorLu, PJ-
dc.contributor.authorCheah, KSE-
dc.date.accessioned2019-09-10T02:58:51Z-
dc.date.available2019-09-10T02:58:51Z-
dc.date.issued2019-
dc.identifier.citationCurrent Opinion in Genetics & Development, 2019, v. 57, p. 84-90-
dc.identifier.issn0959-437X-
dc.identifier.urihttp://hdl.handle.net/10722/276240-
dc.description.abstractThe emergence of multipotent and migratory neural crest (NC) cells defines a key evolutionary transition from invertebrates to vertebrates. Studies in vertebrates have identified a complex gene regulatory network that governs sequential stages of NC ontogeny. Comparative analysis has revealed extensive conservation of the overall architecture of the NC gene regulatory network between jawless and jawed vertebrates. Among invertebrates, urochordates express putative NC gene homologs in the neural plate border region, but these NC-like cells do not have migratory capacity, whereas cephalochordates contain no NC cells but its genome contains most homologs of vertebrate NC genes. Whether the absence of migratory NC cells in invertebrates is due to differences in enhancer elements or an intrinsic limitation in potency remains unclear. We provide a brief overview of mechanisms that might explain how ancestral NC-like cells acquired the multipotency and migratory capacity seen in vertebrates.-
dc.languageeng-
dc.publisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/gde-
dc.relation.ispartofCurrent Opinion in Genetics & Development-
dc.titleAcquisition of multipotent and migratory neural crest cells in vertebrate evolution-
dc.typeArticle-
dc.identifier.emailCheung, M: mcheung9@hku.hk-
dc.identifier.emailLu, PJ: jnlu@hku.hk-
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hk-
dc.identifier.authorityCheung, M=rp00245-
dc.identifier.authorityCheah, KSE=rp00342-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.gde.2019.07.018-
dc.identifier.pmid31470291-
dc.identifier.scopuseid_2-s2.0-85071253907-
dc.identifier.hkuros304284-
dc.identifier.volume57-
dc.identifier.spage84-
dc.identifier.epage90-
dc.publisher.placeUnited Kingdom-

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