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Article: Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients

TitleThrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients
Authors
KeywordsMyocardial infarction
Secondary prevention
TRS 2°P
Issue Date2019
PublisherAmerican Heart Association. The Journal's web site is located at http://circ.ahajournals.org
Citation
Circulation, 2019, v. 83 n. 4, p. 809-817 How to Cite?
AbstractBackground: Patients who survive myocardial infarction (MI) are at risk of recurrent cardiovascular (CV) events. This study stratified post-MI patients for risk of recurrent CV events using the Thrombolysis in Myocardial Infarction (TIMI) Risk Score for Secondary Prevention (TRS 2°P). Methods and Results: This was an observational study that applied TRS 2°P to a consecutive cohort of post-MI patients. The primary outcome was a composite endpoint of CV death, non-fatal MI, and non-fatal ischemic stroke. A total of 1,688 post-MI patients (70.3±13.6 years; male, 63.1%) were enrolled. After a mean follow-up of 41.5±34.4 months, 405 patients (24.0%) had developed a primary outcome (9.3%/year) consisting of 278 CV deaths, 134 non-fatal MI, and 33 non-fatal strokes. TRS 2°P was strongly associated with the primary outcome. The annual incidence of primary composite endpoint for patients with TRS 2°P 0 was 1.0%, and increased progressively to 39.9% for those with TRS 2°P ≥6 (HR, 27.6; 95% CI: 9.87–77.39, P<0.001). The diagnostic sensitivity of TRS 2°P for the primary composite endpoint was 76.3% (95% CI: 72.1–80.5%). Similar associations were also observed between TRS 2°P and CV death and non-fatal MI, but not non-fatal ischemic stroke. Conclusions: TRS 2°P reliably stratified post-MI patients for risk of future CV events.
Persistent Identifierhttp://hdl.handle.net/10722/275734
ISSN
2017 Impact Factor: 18.881
2015 SCImago Journal Rankings: 7.853

 

DC FieldValueLanguage
dc.contributor.authorHuang, D-
dc.contributor.authorCheng, YY-
dc.contributor.authorWong, YTA-
dc.contributor.authorYung, SYA-
dc.contributor.authorTam, CCF-
dc.contributor.authorChan, KWK-
dc.contributor.authorLam, CCS-
dc.contributor.authorYiu, KH-
dc.contributor.authorHai, JJ-
dc.contributor.authorLau, CP-
dc.contributor.authorChan, EW-
dc.contributor.authorChiang, CE-
dc.contributor.authorWong, KL-
dc.contributor.authorCheung, T-
dc.contributor.authorCheung, BMY-
dc.contributor.authorFeng, YQ-
dc.contributor.authorTan, N-
dc.contributor.authorChen, JY-
dc.contributor.authorYue, WS-
dc.contributor.authorHu, HX-
dc.contributor.authorChen, L-
dc.contributor.authorTse, HF-
dc.contributor.authorChan, PH-
dc.contributor.authorSiu, CW-
dc.date.accessioned2019-09-10T02:48:36Z-
dc.date.available2019-09-10T02:48:36Z-
dc.date.issued2019-
dc.identifier.citationCirculation, 2019, v. 83 n. 4, p. 809-817-
dc.identifier.issn0009-7322-
dc.identifier.urihttp://hdl.handle.net/10722/275734-
dc.description.abstractBackground: Patients who survive myocardial infarction (MI) are at risk of recurrent cardiovascular (CV) events. This study stratified post-MI patients for risk of recurrent CV events using the Thrombolysis in Myocardial Infarction (TIMI) Risk Score for Secondary Prevention (TRS 2°P). Methods and Results: This was an observational study that applied TRS 2°P to a consecutive cohort of post-MI patients. The primary outcome was a composite endpoint of CV death, non-fatal MI, and non-fatal ischemic stroke. A total of 1,688 post-MI patients (70.3±13.6 years; male, 63.1%) were enrolled. After a mean follow-up of 41.5±34.4 months, 405 patients (24.0%) had developed a primary outcome (9.3%/year) consisting of 278 CV deaths, 134 non-fatal MI, and 33 non-fatal strokes. TRS 2°P was strongly associated with the primary outcome. The annual incidence of primary composite endpoint for patients with TRS 2°P 0 was 1.0%, and increased progressively to 39.9% for those with TRS 2°P ≥6 (HR, 27.6; 95% CI: 9.87–77.39, P<0.001). The diagnostic sensitivity of TRS 2°P for the primary composite endpoint was 76.3% (95% CI: 72.1–80.5%). Similar associations were also observed between TRS 2°P and CV death and non-fatal MI, but not non-fatal ischemic stroke. Conclusions: TRS 2°P reliably stratified post-MI patients for risk of future CV events.-
dc.languageeng-
dc.publisherAmerican Heart Association. The Journal's web site is located at http://circ.ahajournals.org-
dc.relation.ispartofCirculation-
dc.subjectMyocardial infarction-
dc.subjectSecondary prevention-
dc.subjectTRS 2°P-
dc.titleThrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients-
dc.typeArticle-
dc.identifier.emailHuang, D: huangduo@hku.hk-
dc.identifier.emailCheng, YY: yy520710@HKUCC-COM.hku.hk-
dc.identifier.emailWong, YTA: wongyta@hku.hk-
dc.identifier.emailTam, CCF: fcctam@hku.hk-
dc.identifier.emailChan, KWK: kkwchan1@hku.hk-
dc.identifier.emailLam, CCS: scclam@hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.emailHai, JJ: haishjj@hku.hk-
dc.identifier.emailLau, CP: cplau@hkucc.hku.hk-
dc.identifier.emailChan, EW: ewchan@hku.hk-
dc.identifier.emailWong, KL: micangus@hku.hk-
dc.identifier.emailCheung, T: tcheungt@HKUCC-COM.hku.hk-
dc.identifier.emailCheung, BMY: mycheung@hkucc.hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailChan, PH: phmchan@hku.hk-
dc.identifier.emailSiu, CW: cwdsiu@hkucc.hku.hk-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.authorityHai, JJ=rp02047-
dc.identifier.authorityChan, EW=rp01587-
dc.identifier.authorityCheung, T=rp01682-
dc.identifier.authorityCheung, BMY=rp01321-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityChan, PH=rp01864-
dc.identifier.authoritySiu, CW=rp00534-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1253/circj.CJ-18-0308-
dc.identifier.pmid30799311-
dc.identifier.scopuseid_2-s2.0-85063711986-
dc.identifier.hkuros303025-
dc.identifier.volume83-
dc.identifier.issue4-
dc.identifier.spage809-
dc.identifier.epage817-
dc.publisher.placeUnited States-

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