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Article: TIMI risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-non-ST-elevation myocardial infarction patients

TitleTIMI risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-non-ST-elevation myocardial infarction patients
Authors
KeywordsAnnonaceae
Mitrephora monocarpa
New species
Thailand
Issue Date2019
PublisherBMJ Publishing Group. The Journal's web site is located at http://www.postgradmedj.com
Citation
Postgraduate Medical Journal, 2019, v. 95 n. 1125, p. 372-377 How to Cite?
AbstractBackground Patients who survive non-ST-elevation myocardial infarction (NSTEMI) are at heightened risk of recurrent cardiovascular events. Data on long-term secondary atherothrombotic risk stratification are limited. Objectives To stratify post-NSTEMI patients for risk of recurrent cardiovascular events to maximise benefit from aggressive secondary prevention strategies using the TIMI Risk Score for Secondary Prevention (TRS 2°P) score in a real-world cohort of NSTEMI patients. Methods and results This was a single-centre observational study of 891 post-NSTEMI patients (73.7 ± 12.7 years; male: 54.2%). The TRS 2°P is a nine-point risk stratification tool to predict cardiovascular events in patients with established cardiovascular disease. The primary outcome was a composite endpoint of cardiovascular death, non-fatal MI and non-fatal ischaemic stroke. After a median follow-up of 31 months (IQR: 11.4 – 60.2), 281 patients (31.5%) had developed a primary outcome (13.3%/year) including 196 cardiovascular deaths, 94 non-fatal MIs and 22 non-fatal strokes. The TRS 2°P score was strongly associated with the primary outcome. The annual incidence of primary composite endpoint for patients with TRS 2°P score =0 was 1.6%, and increased progressively to 47.4% for those with a TRS 2°P score ≥6 (HR: 20.18, 95% CI: 4.85 to 84.05, p<0.001). Similar associations were also observed between the TRS 2°P score and cardiovascular death and MI (fatal and non-fatal), but not non-fatal ischaemic stroke. Conclusion The TRS 2°P score stratified post-NSTEMI patients for risk of future cardiovascular events and potentially help guide the selection of more aggressive secondary prevention therapy.
DescriptionLink to Free access
Persistent Identifierhttp://hdl.handle.net/10722/275118
ISSN
2017 Impact Factor: 2.078
2015 SCImago Journal Rankings: 0.531

 

DC FieldValueLanguage
dc.contributor.authorHuang, D-
dc.contributor.authorCheng, YY-
dc.contributor.authorWong, YT-
dc.contributor.authorYung, SY-
dc.contributor.authorChan, KW-
dc.contributor.authorLam, CC-
dc.contributor.authorHai, JJ-
dc.contributor.authorLau, CP-
dc.contributor.authorWong, KL-
dc.contributor.authorFeng, YQ-
dc.contributor.authorTan, N-
dc.contributor.authorChen, JY-
dc.contributor.authorWu, MX-
dc.contributor.authorSu, X-
dc.contributor.authorYan, H-
dc.contributor.authorSong, D-
dc.contributor.authorTse, HF-
dc.contributor.authorChan, PH-
dc.contributor.authorSiu, CW-
dc.contributor.authorTam, CC-
dc.date.accessioned2019-09-10T02:35:49Z-
dc.date.available2019-09-10T02:35:49Z-
dc.date.issued2019-
dc.identifier.citationPostgraduate Medical Journal, 2019, v. 95 n. 1125, p. 372-377-
dc.identifier.issn0032-5473-
dc.identifier.urihttp://hdl.handle.net/10722/275118-
dc.descriptionLink to Free access-
dc.description.abstractBackground Patients who survive non-ST-elevation myocardial infarction (NSTEMI) are at heightened risk of recurrent cardiovascular events. Data on long-term secondary atherothrombotic risk stratification are limited. Objectives To stratify post-NSTEMI patients for risk of recurrent cardiovascular events to maximise benefit from aggressive secondary prevention strategies using the TIMI Risk Score for Secondary Prevention (TRS 2°P) score in a real-world cohort of NSTEMI patients. Methods and results This was a single-centre observational study of 891 post-NSTEMI patients (73.7 ± 12.7 years; male: 54.2%). The TRS 2°P is a nine-point risk stratification tool to predict cardiovascular events in patients with established cardiovascular disease. The primary outcome was a composite endpoint of cardiovascular death, non-fatal MI and non-fatal ischaemic stroke. After a median follow-up of 31 months (IQR: 11.4 – 60.2), 281 patients (31.5%) had developed a primary outcome (13.3%/year) including 196 cardiovascular deaths, 94 non-fatal MIs and 22 non-fatal strokes. The TRS 2°P score was strongly associated with the primary outcome. The annual incidence of primary composite endpoint for patients with TRS 2°P score =0 was 1.6%, and increased progressively to 47.4% for those with a TRS 2°P score ≥6 (HR: 20.18, 95% CI: 4.85 to 84.05, p<0.001). Similar associations were also observed between the TRS 2°P score and cardiovascular death and MI (fatal and non-fatal), but not non-fatal ischaemic stroke. Conclusion The TRS 2°P score stratified post-NSTEMI patients for risk of future cardiovascular events and potentially help guide the selection of more aggressive secondary prevention therapy.-
dc.languageeng-
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://www.postgradmedj.com-
dc.relation.ispartofPostgraduate Medical Journal-
dc.rightsPostgraduate Medical Journal. Copyright © BMJ Publishing Group.-
dc.rightsThis article has been accepted for publication in [Journal, Year] following peer review, and the Version of Record can be accessed online at [insert full DOI eg. http://dx.doi.org/10.1136/xxxxx]. [© Authors (or their employer(s)) OR © BMJ Publishing Group Ltd ( for assignments of BMJ Case Reports)] <year>-
dc.subjectAnnonaceae-
dc.subjectMitrephora monocarpa-
dc.subjectNew species-
dc.subjectThailand-
dc.titleTIMI risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-non-ST-elevation myocardial infarction patients-
dc.typeArticle-
dc.identifier.emailHuang, D: huangduo@hku.hk-
dc.identifier.emailCheng, YY: yy520710@HKUCC-COM.hku.hk-
dc.identifier.emailWong, YT: wongyta@hku.hk-
dc.identifier.emailChan, KW: kkwchan1@hku.hk-
dc.identifier.emailLam, CC: scclam@hku.hk-
dc.identifier.emailHai, JJ: haishjj@hku.hk-
dc.identifier.emailLau, CP: cplau@hkucc.hku.hk-
dc.identifier.emailWong, KL: micangus@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailChan, PH: phmchan@hku.hk-
dc.identifier.emailSiu, CW: cwdsiu@hkucc.hku.hk-
dc.identifier.emailTam, CC: fcctam@hku.hk-
dc.identifier.authorityHai, JJ=rp02047-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityChan, PH=rp01864-
dc.identifier.authoritySiu, CW=rp00534-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1136/postgradmedj-2019-136404-
dc.identifier.pmid31123174-
dc.identifier.scopuseid_2-s2.0-85065879152-
dc.identifier.hkuros304619-
dc.identifier.volume95-
dc.identifier.issue1125-
dc.identifier.spage372-
dc.identifier.epage377-
dc.publisher.placeUnited Kingdom-

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