File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Resting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers

TitleResting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers
Authors
Issue Date2018
PublisherBioMed Central Ltd.. The Journal's web site is located at https://cardiooncologyjournal.biomedcentral.com
Citation
Cardio-Oncology, 2018, v. 4, p. article no. 9 How to Cite?
AbstractBackground: Emerging evidence suggests potential arterial damage with the use of anthracycline-basedchemotherapeutic regimens. We determined arterial function at rest and during exercise in anthracycline-treated adultsurvivors of childhood cancers.Methods: Ninety-six adult survivors (54 males) aged 25.0 ± 5.9 years and 60 (30 males) healthy controls were studied.Central systolic blood pressure (cSBP) and radial augmentation index (rAI) was determined by applanation tonometry.Carotid arterial stiffness and intima-media thickness (IMT) were assessed using high-resolution ultrasound.Results: At rest, survivors had significantly greater carotid IMT (p< 0.001) and stiffness index (p < 0.001), andhigher cSBP (p= 0.037), rAI (p= 0.004) and rAI adjusted for a heart rate of 75/min (p= 0.009) than controls. Atsubmaximal supine exercise testing, survivors had significantly greater percentage increase in carotid stiffnessthan controls (p< 0.001). Among survivors, 32 and 53% had respectively carotid IMT and exercise stiffnessindex exceeding normal (> + 2SD of controls). The slopes of increase in carotid IMT (p< 0.001) and exercise-inducedchanges in carotid stiffness (p< 0.001) with age were significantly greater in survivors than controls. Multivariateanalysis revealed carotid IMT (β=0.32,p< 0.001) to be an significant correlate of dynamic percentage increase instiffness index during exercise.Conclusions: Arterial dysfunction is evident at rest and worsens during exercise in anthracycline-treated adult survivorsof childhood cancers.
Persistent Identifierhttp://hdl.handle.net/10722/273990
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLi, WYV-
dc.contributor.authorLiu, APY-
dc.contributor.authorHo, KK-
dc.contributor.authorYau, JP-
dc.contributor.authorCheuk, KLD-
dc.contributor.authorCheung, YF-
dc.date.accessioned2019-08-18T14:52:50Z-
dc.date.available2019-08-18T14:52:50Z-
dc.date.issued2018-
dc.identifier.citationCardio-Oncology, 2018, v. 4, p. article no. 9-
dc.identifier.issn2057-3804-
dc.identifier.urihttp://hdl.handle.net/10722/273990-
dc.description.abstractBackground: Emerging evidence suggests potential arterial damage with the use of anthracycline-basedchemotherapeutic regimens. We determined arterial function at rest and during exercise in anthracycline-treated adultsurvivors of childhood cancers.Methods: Ninety-six adult survivors (54 males) aged 25.0 ± 5.9 years and 60 (30 males) healthy controls were studied.Central systolic blood pressure (cSBP) and radial augmentation index (rAI) was determined by applanation tonometry.Carotid arterial stiffness and intima-media thickness (IMT) were assessed using high-resolution ultrasound.Results: At rest, survivors had significantly greater carotid IMT (p< 0.001) and stiffness index (p < 0.001), andhigher cSBP (p= 0.037), rAI (p= 0.004) and rAI adjusted for a heart rate of 75/min (p= 0.009) than controls. Atsubmaximal supine exercise testing, survivors had significantly greater percentage increase in carotid stiffnessthan controls (p< 0.001). Among survivors, 32 and 53% had respectively carotid IMT and exercise stiffnessindex exceeding normal (> + 2SD of controls). The slopes of increase in carotid IMT (p< 0.001) and exercise-inducedchanges in carotid stiffness (p< 0.001) with age were significantly greater in survivors than controls. Multivariateanalysis revealed carotid IMT (β=0.32,p< 0.001) to be an significant correlate of dynamic percentage increase instiffness index during exercise.Conclusions: Arterial dysfunction is evident at rest and worsens during exercise in anthracycline-treated adult survivorsof childhood cancers.-
dc.languageeng-
dc.publisherBioMed Central Ltd.. The Journal's web site is located at https://cardiooncologyjournal.biomedcentral.com-
dc.relation.ispartofCardio-Oncology-
dc.rightsCardio-Oncology. Copyright © BioMed Central Ltd..-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleResting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers-
dc.typeArticle-
dc.identifier.emailLi, WYV: wyvli@hku.hk-
dc.identifier.emailLiu, APY: apyliu@hku.hk-
dc.identifier.emailCheuk, KLD: klcheuk@hkucc.hku.hk-
dc.identifier.emailCheung, YF: xfcheung@hku.hk-
dc.identifier.authorityLiu, APY=rp01357-
dc.identifier.authorityCheung, YF=rp00382-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s40959-018-0035-0-
dc.identifier.hkuros301085-
dc.identifier.volume4-
dc.identifier.spagearticle no. 9-
dc.identifier.epagearticle no. 9-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats