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Article: Recognition of double-stranded RNA and regulation of interferon pathway by toll-like Receptor 10

TitleRecognition of double-stranded RNA and regulation of interferon pathway by toll-like Receptor 10
Authors
Issue Date2018
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology
Citation
Frontiers in Immunology, 2018, v. 9, p. 516:1-516:15 How to Cite?
AbstractToll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid differentiation primary response gene 88 for signal transduction and suppression of interferon regulatory factor-7 dependent type I IFN production. We also demonstrate crosstalk between TLR10 and TLR3, as they compete with each other for dsRNA binding. Our results suggest for the first time that dsRNA is a ligand for TLR10 and propose novel dual functions of TLR10 in regulating IFN signaling: first, recognition of dsRNA as a nucleotide-sensing receptor and second, sequestration of dsRNA from TLR3 to inhibit TLR3 signaling in response to dsRNA stimulation.
Persistent Identifierhttp://hdl.handle.net/10722/258333
ISSN
2015 Impact Factor: 5.695
2015 SCImago Journal Rankings: 2.810
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorLee, MY-
dc.contributor.authorYip, TF-
dc.contributor.authorYan, S-
dc.contributor.authorJin, D-
dc.contributor.authorWei, HL-
dc.contributor.authorGuo, RT-
dc.contributor.authorPeiris, JSM-
dc.date.accessioned2018-08-22T01:36:48Z-
dc.date.available2018-08-22T01:36:48Z-
dc.date.issued2018-
dc.identifier.citationFrontiers in Immunology, 2018, v. 9, p. 516:1-516:15-
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10722/258333-
dc.description.abstractToll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid differentiation primary response gene 88 for signal transduction and suppression of interferon regulatory factor-7 dependent type I IFN production. We also demonstrate crosstalk between TLR10 and TLR3, as they compete with each other for dsRNA binding. Our results suggest for the first time that dsRNA is a ligand for TLR10 and propose novel dual functions of TLR10 in regulating IFN signaling: first, recognition of dsRNA as a nucleotide-sensing receptor and second, sequestration of dsRNA from TLR3 to inhibit TLR3 signaling in response to dsRNA stimulation.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/immunology-
dc.relation.ispartofFrontiers in Immunology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleRecognition of double-stranded RNA and regulation of interferon pathway by toll-like Receptor 10-
dc.typeArticle-
dc.identifier.emailLee, MY: suki@hku.hk-
dc.identifier.emailYip, TF: yiptf@hku.hk-
dc.identifier.emailYan, S: ssyan@hku.hk-
dc.identifier.emailJin, D: dyjin@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityLee, MY=rp01536-
dc.identifier.authorityJin, D=rp00452-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fimmu.2018.00516-
dc.identifier.pmcidPMC5865411-
dc.identifier.hkuros286571-
dc.identifier.volume9-
dc.identifier.spage516:1-
dc.identifier.epage516:15-
dc.publisher.placeSwitzerland-

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