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Article: Calcium-based caries preventive agents: A meta-evaluation of systematic reviews and meta-analysis

TitleCalcium-based caries preventive agents: A meta-evaluation of systematic reviews and meta-analysis
Authors
KeywordsArginine
Calcium
CPP-ACP
Dental caries
Prevention
Issue Date2018
PublisherMosby, Inc. The Journal's web site is located at http://www.jebdp.com
Citation
Journal of Evidence Based Dental Practice, 2018, v. 18 n. 3, p. 203-217.e4 How to Cite?
AbstractObjective: This article aims to assess systematic reviews and/or meta-analyses on calcium-based caries preventive agents, evaluating reported evidence, thereby summarizing a critical appraisal on the subject. Materials and methods: A systematic search was done using PubMed, Cochrane Library, and Web of Science. Systematic reviews and/or meta-analyses addressing PICO: P: any age or gender; I: calcium-based caries preventive agents; C: with/without control; and O: any early caries lesion measures were included. Inter-reviewer reliability was assessed using Cohen's kappa coefficient. Results: One hundred sixty-four records were identified, of which 10 (κ = 1.00) were included for quality evaluation. Seven reviews were systematic reviews (only), whereas 3 were meta-analyses. None of the articles provided with an “a priori” review design. Majority of the reviews (7 of 10) were of high quality as assessed by Assessing the Methodological Quality of Systematic Reviews, whereas 3 articles were scored as moderate quality of evidence. All the included meta-analyses were of high-quality evidence as assessed by meta-evaluation of meta-analysis: 10 appraisal questions for biologists. Eight reviews addressed the intervention: casein phosphopeptide-amorphous calcium phosphate (CPP-ACP)/casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP). Two reviews were performed on arginine-containing formulations. Majority of the high-quality systematic reviews were inconclusive over the effects of CPP-ACP/CPP-ACFP. Conclusion: This meta-evaluation suggests that CPP-ACP/CPP-ACFP can be considered as an adjunct to fluorides but not as an alternative until long-term well-designed clinical trials assessed by systematic reviews and meta-analysis are available. Arginine-containing dentifrice with an insoluble calcium base and fluoride seem to be a promising agent, but more well-designed non-industry–supported clinical trials can provide better insights in future. © 2017 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/249582
ISSN
2017 Impact Factor: 2.4
2015 SCImago Journal Rankings: 0.563
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBijle, MNA-
dc.contributor.authorYiu, CKY-
dc.contributor.authorEkambaram, M-
dc.date.accessioned2017-11-21T03:04:13Z-
dc.date.available2017-11-21T03:04:13Z-
dc.date.issued2018-
dc.identifier.citationJournal of Evidence Based Dental Practice, 2018, v. 18 n. 3, p. 203-217.e4-
dc.identifier.issn1532-3382-
dc.identifier.urihttp://hdl.handle.net/10722/249582-
dc.description.abstractObjective: This article aims to assess systematic reviews and/or meta-analyses on calcium-based caries preventive agents, evaluating reported evidence, thereby summarizing a critical appraisal on the subject. Materials and methods: A systematic search was done using PubMed, Cochrane Library, and Web of Science. Systematic reviews and/or meta-analyses addressing PICO: P: any age or gender; I: calcium-based caries preventive agents; C: with/without control; and O: any early caries lesion measures were included. Inter-reviewer reliability was assessed using Cohen's kappa coefficient. Results: One hundred sixty-four records were identified, of which 10 (κ = 1.00) were included for quality evaluation. Seven reviews were systematic reviews (only), whereas 3 were meta-analyses. None of the articles provided with an “a priori” review design. Majority of the reviews (7 of 10) were of high quality as assessed by Assessing the Methodological Quality of Systematic Reviews, whereas 3 articles were scored as moderate quality of evidence. All the included meta-analyses were of high-quality evidence as assessed by meta-evaluation of meta-analysis: 10 appraisal questions for biologists. Eight reviews addressed the intervention: casein phosphopeptide-amorphous calcium phosphate (CPP-ACP)/casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP). Two reviews were performed on arginine-containing formulations. Majority of the high-quality systematic reviews were inconclusive over the effects of CPP-ACP/CPP-ACFP. Conclusion: This meta-evaluation suggests that CPP-ACP/CPP-ACFP can be considered as an adjunct to fluorides but not as an alternative until long-term well-designed clinical trials assessed by systematic reviews and meta-analysis are available. Arginine-containing dentifrice with an insoluble calcium base and fluoride seem to be a promising agent, but more well-designed non-industry–supported clinical trials can provide better insights in future. © 2017 Elsevier Inc.-
dc.languageeng-
dc.publisherMosby, Inc. The Journal's web site is located at http://www.jebdp.com-
dc.relation.ispartofJournal of Evidence Based Dental Practice-
dc.subjectArginine-
dc.subjectCalcium-
dc.subjectCPP-ACP-
dc.subjectDental caries-
dc.subjectPrevention-
dc.titleCalcium-based caries preventive agents: A meta-evaluation of systematic reviews and meta-analysis-
dc.typeArticle-
dc.identifier.emailYiu, CKY: ckyyiu@hkucc.hku.hk-
dc.identifier.emailEkambaram, M: drmani@hku.hk-
dc.identifier.authorityYiu, CKY=rp00018-
dc.identifier.authorityEkambaram, M=rp02026-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jebdp.2017.09.003-
dc.identifier.scopuseid_2-s2.0-85039045475-
dc.identifier.hkuros283226-
dc.identifier.volume18-
dc.identifier.issue3-
dc.identifier.spage203-
dc.identifier.epage217.e4-
dc.identifier.isiWOS:000440592900003-
dc.publisher.placeUnited States-

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