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Conference Paper: Self-assembled synthetic ion channels

TitleSelf-assembled synthetic ion channels
Authors
Issue Date2017
PublisherAmerican Chemical Society.
Citation
The 253rd American Chemical Society National Meeting & Exposition , San Francisco, CA, 2–6 April 2017 How to Cite?
AbstractUnlike ion channel modulators that act on natural ion channel proteins, synthetic ion channels are small organic molecules that self-assemble to form ion channels in cell membranes irrespective of the presence of natural ion channels. By using HPTS assay, Ussing chamber, and patch-clamp single channel recording, we have discovered a range of small molecules with unique physical properties and excellent ion selectivity. In addition, on the basis of structural studied using STD-NMR, NOESY-NMR and CD methods, we have proposed models of self-assembled ion channels and further evaluated them using all-atom molecular dynamics simulations. Those synthetic ion channels may offer great opportunity to resolve unmet medical needs.
DescriptionSession: Current Topics in Biochemistry - no. BIOL 202
Persistent Identifierhttp://hdl.handle.net/10722/247751

 

DC FieldValueLanguage
dc.contributor.authorYang, D-
dc.date.accessioned2017-10-18T08:32:04Z-
dc.date.available2017-10-18T08:32:04Z-
dc.date.issued2017-
dc.identifier.citationThe 253rd American Chemical Society National Meeting & Exposition , San Francisco, CA, 2–6 April 2017-
dc.identifier.urihttp://hdl.handle.net/10722/247751-
dc.descriptionSession: Current Topics in Biochemistry - no. BIOL 202-
dc.description.abstractUnlike ion channel modulators that act on natural ion channel proteins, synthetic ion channels are small organic molecules that self-assemble to form ion channels in cell membranes irrespective of the presence of natural ion channels. By using HPTS assay, Ussing chamber, and patch-clamp single channel recording, we have discovered a range of small molecules with unique physical properties and excellent ion selectivity. In addition, on the basis of structural studied using STD-NMR, NOESY-NMR and CD methods, we have proposed models of self-assembled ion channels and further evaluated them using all-atom molecular dynamics simulations. Those synthetic ion channels may offer great opportunity to resolve unmet medical needs.-
dc.languageeng-
dc.publisherAmerican Chemical Society. -
dc.relation.ispartofAmerican Chemical Society National Meeting & Exposition, April 2017-
dc.titleSelf-assembled synthetic ion channels-
dc.typeConference_Paper-
dc.identifier.emailYang, D: yangdan@hku.hk-
dc.identifier.authorityYang, D=rp00825-
dc.identifier.hkuros281536-
dc.publisher.placeSan Francisco, CA-

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