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Article: SOXE neofunctionalization and elaboration of the neural crest during chordate evolution

TitleSOXE neofunctionalization and elaboration of the neural crest during chordate evolution
Authors
Issue Date2016
PublisherNature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2016, v. 6, p. 34964:1-13 How to Cite?
AbstractDuring chordate evolution, two genome-wide duplications facilitated acquisition of vertebrate traits, including emergence of neural crest cells (NCCs), in which neofunctionalization of the duplicated genes are thought to have facilitated development of craniofacial structures and the peripheral nervous system. How these duplicated genes evolve and acquire the ability to specify NC and their derivatives are largely unknown. Vertebrate SoxE paralogues, most notably Sox9/10, are essential for NC induction, delamination and lineage specification. In contrast, the basal chordate, amphioxus, has a single SoxE gene and lacks NC-like cells. Here, we test the hypothesis that duplication and divergence of an ancestral SoxE gene may have facilitated elaboration of NC lineages. By using an in vivo expression assay to compare effects of AmphiSoxE and vertebrate Sox9 on NC development, we demonstrate that all SOXE proteins possess similar DNA binding and homodimerization properties and can induce NCCs. However, AmphiSOXE is less efficient than SOX9 in transactivation activity and in the ability to preferentially promote glial over neuronal fate, a difference that lies within the combined properties of amino terminal and transactivation domains. We propose that acquisition of AmphiSoxE expression in the neural plate border led to NCC emergence while duplication and divergence produced advantageous mutations in vertebrate homologues, promoting elaboration of NC traits.
Persistent Identifierhttp://hdl.handle.net/10722/241532
ISSN
2017 Impact Factor: 4.122
2015 SCImago Journal Rankings: 2.073
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTai, CP-
dc.contributor.authorCheung, MCH-
dc.contributor.authorHuang, YH-
dc.contributor.authorJauch, R-
dc.contributor.authorBronner, ME-
dc.contributor.authorCheah, KSE-
dc.date.accessioned2017-06-20T01:45:00Z-
dc.date.available2017-06-20T01:45:00Z-
dc.date.issued2016-
dc.identifier.citationScientific Reports, 2016, v. 6, p. 34964:1-13-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/241532-
dc.description.abstractDuring chordate evolution, two genome-wide duplications facilitated acquisition of vertebrate traits, including emergence of neural crest cells (NCCs), in which neofunctionalization of the duplicated genes are thought to have facilitated development of craniofacial structures and the peripheral nervous system. How these duplicated genes evolve and acquire the ability to specify NC and their derivatives are largely unknown. Vertebrate SoxE paralogues, most notably Sox9/10, are essential for NC induction, delamination and lineage specification. In contrast, the basal chordate, amphioxus, has a single SoxE gene and lacks NC-like cells. Here, we test the hypothesis that duplication and divergence of an ancestral SoxE gene may have facilitated elaboration of NC lineages. By using an in vivo expression assay to compare effects of AmphiSoxE and vertebrate Sox9 on NC development, we demonstrate that all SOXE proteins possess similar DNA binding and homodimerization properties and can induce NCCs. However, AmphiSOXE is less efficient than SOX9 in transactivation activity and in the ability to preferentially promote glial over neuronal fate, a difference that lies within the combined properties of amino terminal and transactivation domains. We propose that acquisition of AmphiSoxE expression in the neural plate border led to NCC emergence while duplication and divergence produced advantageous mutations in vertebrate homologues, promoting elaboration of NC traits.-
dc.languageeng-
dc.publisherNature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSOXE neofunctionalization and elaboration of the neural crest during chordate evolution-
dc.typeArticle-
dc.identifier.emailTai, CP: cpandrew@hku.hk-
dc.identifier.emailCheung, MCH: mcheung9@hku.hk-
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hk-
dc.identifier.authorityCheung, MCH=rp00245-
dc.identifier.authorityCheah, KSE=rp00342-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/srep34964-
dc.identifier.scopuseid_2-s2.0-84992745729-
dc.identifier.hkuros272653-
dc.identifier.volume6-
dc.identifier.spage34964:1-
dc.identifier.epage13-
dc.identifier.isiWOS:000385463700001-
dc.publisher.placeUnited Kingdom-

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