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Article: Rutin increases the cytotoxicity of temozolomide in glioblastoma via autophagy inhibition

TitleRutin increases the cytotoxicity of temozolomide in glioblastoma via autophagy inhibition
Authors
KeywordsApoptosis
Autophagy
Glioblastoma multiforme
Rutin
Temozolomide
Issue Date2017
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0167-594X
Citation
Journal of Neuro-Oncology, 2017, v. 132 n. 3, p. 383-400 How to Cite?
AbstractThe chemotherapeutic agent temozolomide (TMZ) is widely used in the treatment of glioblastoma multiforme (GBM). Rutin, a citrus flavonoid ecglycoside found in edible plants, has neuroprotective and anticancer activities. This study aimed to investigate the efficacy and the underlying mechanisms of rutin used in combination with TMZ in GBM. In vitro cell viability assay demonstrated that rutin alone had generally low cytotoxic effect, but it enhanced the efficacy of TMZ in a dose-dependent manner. Subcutaneous and orthotopic xenograft studies also showed that tumor volumes were significantly lower in mice receiving combined TMZ/Rutin treatment as compared to TMZ or rutin alone treatment. Moreover, immunoblotting analysis showed that TMZ activated JNK activity to induce protective response autophagy, which was blocked by rutin, resulting in decreased autophagy and increased apoptosis, suggesting that rutin enhances TMZ efficacy both in vitro and in vivo via inhibiting JNK-mediated autophagy in GBM. The combination rutin with TMZ may be a potentially useful therapeutic approach for GBM patient. © 2017, Springer Science+Business Media New York.
Persistent Identifierhttp://hdl.handle.net/10722/240352
ISSN
2017 Impact Factor: 3.06
2015 SCImago Journal Rankings: 1.274
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, P-
dc.contributor.authorSun, S-
dc.contributor.authorLi, N-
dc.contributor.authorHo, SWA-
dc.contributor.authorKiang, KMY-
dc.contributor.authorZhang, X-
dc.contributor.authorCheng, Y-
dc.contributor.authorPoon, MW-
dc.contributor.authorLee, D-
dc.contributor.authorPu, KSJ-
dc.contributor.authorLeung, GKK-
dc.date.accessioned2017-04-19T08:23:17Z-
dc.date.available2017-04-19T08:23:17Z-
dc.date.issued2017-
dc.identifier.citationJournal of Neuro-Oncology, 2017, v. 132 n. 3, p. 383-400-
dc.identifier.issn0167-594X-
dc.identifier.urihttp://hdl.handle.net/10722/240352-
dc.description.abstractThe chemotherapeutic agent temozolomide (TMZ) is widely used in the treatment of glioblastoma multiforme (GBM). Rutin, a citrus flavonoid ecglycoside found in edible plants, has neuroprotective and anticancer activities. This study aimed to investigate the efficacy and the underlying mechanisms of rutin used in combination with TMZ in GBM. In vitro cell viability assay demonstrated that rutin alone had generally low cytotoxic effect, but it enhanced the efficacy of TMZ in a dose-dependent manner. Subcutaneous and orthotopic xenograft studies also showed that tumor volumes were significantly lower in mice receiving combined TMZ/Rutin treatment as compared to TMZ or rutin alone treatment. Moreover, immunoblotting analysis showed that TMZ activated JNK activity to induce protective response autophagy, which was blocked by rutin, resulting in decreased autophagy and increased apoptosis, suggesting that rutin enhances TMZ efficacy both in vitro and in vivo via inhibiting JNK-mediated autophagy in GBM. The combination rutin with TMZ may be a potentially useful therapeutic approach for GBM patient. © 2017, Springer Science+Business Media New York.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0167-594X-
dc.relation.ispartofJournal of Neuro-Oncology-
dc.subjectApoptosis-
dc.subjectAutophagy-
dc.subjectGlioblastoma multiforme-
dc.subjectRutin-
dc.subjectTemozolomide-
dc.titleRutin increases the cytotoxicity of temozolomide in glioblastoma via autophagy inhibition-
dc.typeArticle-
dc.identifier.emailZhang, P: pingder@hku.hk-
dc.identifier.emailSun, S: ssun@hku.hk-
dc.identifier.emailLi, N: ningli@hku.hk-
dc.identifier.emailHo, SWA: hoswa@hku.hk-
dc.identifier.emailKiang, KMY: mykiang@hku.hk-
dc.identifier.emailCheng, Y: yincyns@hku.hk-
dc.identifier.emailPoon, MW: ilmwpoon@hku.hk-
dc.identifier.emailLee, D: leederek@hku.hk-
dc.identifier.emailLeung, GKK: gilberto@hku.hk-
dc.identifier.authorityLeung, GKK=rp00522-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11060-017-2387-y-
dc.identifier.pmid28293765-
dc.identifier.scopuseid_2-s2.0-85015192440-
dc.identifier.hkuros271733-
dc.identifier.volume132-
dc.identifier.issue3-
dc.identifier.spage383-
dc.identifier.epage400-
dc.identifier.isiWOS:000404165900004-
dc.publisher.placeUnited States-

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