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- Publisher Website: 10.1111/liv.13372
- Scopus: eid_2-s2.0-85012918924
- PMID: 28111892
- WOS: WOS:000408482200005
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Article: The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection
Title | The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection |
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Authors | |
Keywords | Age Chronic hepatitis B HBV DNA Interleukin‐27 Spontaneous HBeAg seroconversion |
Issue Date | 2017 |
Publisher | Wiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1 |
Citation | Liver International, 2017, v. 37 n. 9, p. 1287-1294 How to Cite? |
Abstract | BACKGROUND AND AIMS: Hepatitis B e seroconversion, associated with preceding hepatic inflammation, marks the transition from immune active to residual phase in the natural disease history of chronic hepatitis B. Recently, interleukin-27 has been reported to be associated with hepatic inflammation in hepatitis B infection. We aimed to evaluate the role of interleukin-27 in predicting spontaneous e seroconversion in chronic hepatitis B. METHODS: A total of 142 treatment-naive hepatitis B patients with positive e antigen were recruited. Interleukin-27, hepatitis B viral DNA levels and liver function parameters, were measured on presentation. Patients who had spontaneous e seroconversion within 3 years of follow-up were compared with those without e seroconversion within the same period of time. Factors predictive of spontaneous e seroconversion were identified. RESULTS: Of the 142 patients (M:F=80:62, median age: 31), 44 (31%) had spontaneous e seroconversion within 3 years of follow-up. Multivariate analyses revealed that younger age, lower viral DNA and lower interleukin-27 levels on presentation independently predicted spontaneous e seroconversion: the rate was significantly higher in patients aged <31 (OR: 11.022, 95% CI: 3.658-33.205; P<.001), viral DNA <5 log IU/mL (OR: 2.311, 95% CI: 1.049-5.091; P=.038) and interleukin-27 <67.3 pg/mL (OR: 3.276, 95% CI: 1.257-8.536; P=.015). Among patients with all these three favourable factors on presentation, 77% of them underwent spontaneous e seroconversion within 3 years. CONCLUSIONS: Low interleukin-27 levels were associated with early e seroconversion. The combination of baseline interleukin-27 <67.3 pg/mL and viral DNA <5 log IU/mL in young patients was useful for predicting early spontaneous e seroconversion in treatment-naive chronic hepatitis B patients. |
Persistent Identifier | http://hdl.handle.net/10722/240251 |
ISSN | 2023 Impact Factor: 6.0 2023 SCImago Journal Rankings: 2.087 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, J | - |
dc.contributor.author | Mak, LY | - |
dc.contributor.author | Wong, DKH | - |
dc.contributor.author | Fung, J | - |
dc.contributor.author | Seto, WK | - |
dc.contributor.author | Lai, CL | - |
dc.contributor.author | Yuen, MF | - |
dc.date.accessioned | 2017-04-19T08:21:55Z | - |
dc.date.available | 2017-04-19T08:21:55Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Liver International, 2017, v. 37 n. 9, p. 1287-1294 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | http://hdl.handle.net/10722/240251 | - |
dc.description.abstract | BACKGROUND AND AIMS: Hepatitis B e seroconversion, associated with preceding hepatic inflammation, marks the transition from immune active to residual phase in the natural disease history of chronic hepatitis B. Recently, interleukin-27 has been reported to be associated with hepatic inflammation in hepatitis B infection. We aimed to evaluate the role of interleukin-27 in predicting spontaneous e seroconversion in chronic hepatitis B. METHODS: A total of 142 treatment-naive hepatitis B patients with positive e antigen were recruited. Interleukin-27, hepatitis B viral DNA levels and liver function parameters, were measured on presentation. Patients who had spontaneous e seroconversion within 3 years of follow-up were compared with those without e seroconversion within the same period of time. Factors predictive of spontaneous e seroconversion were identified. RESULTS: Of the 142 patients (M:F=80:62, median age: 31), 44 (31%) had spontaneous e seroconversion within 3 years of follow-up. Multivariate analyses revealed that younger age, lower viral DNA and lower interleukin-27 levels on presentation independently predicted spontaneous e seroconversion: the rate was significantly higher in patients aged <31 (OR: 11.022, 95% CI: 3.658-33.205; P<.001), viral DNA <5 log IU/mL (OR: 2.311, 95% CI: 1.049-5.091; P=.038) and interleukin-27 <67.3 pg/mL (OR: 3.276, 95% CI: 1.257-8.536; P=.015). Among patients with all these three favourable factors on presentation, 77% of them underwent spontaneous e seroconversion within 3 years. CONCLUSIONS: Low interleukin-27 levels were associated with early e seroconversion. The combination of baseline interleukin-27 <67.3 pg/mL and viral DNA <5 log IU/mL in young patients was useful for predicting early spontaneous e seroconversion in treatment-naive chronic hepatitis B patients. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1 | - |
dc.relation.ispartof | Liver International | - |
dc.subject | Age | - |
dc.subject | Chronic hepatitis B | - |
dc.subject | HBV DNA | - |
dc.subject | Interleukin‐27 | - |
dc.subject | Spontaneous HBeAg seroconversion | - |
dc.title | The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection | - |
dc.type | Article | - |
dc.identifier.email | Mak, LY: lungyi@hku.hk | - |
dc.identifier.email | Wong, DKH: danywong@hku.hk | - |
dc.identifier.email | Fung, J: jfung@hkucc.hku.hk | - |
dc.identifier.email | Seto, WK: wkseto2@hku.hk | - |
dc.identifier.email | Lai, CL: hrmelcl@hku.hk | - |
dc.identifier.email | Yuen, MF: mfyuen@hku.hk | - |
dc.identifier.authority | Mak, LY=rp02668 | - |
dc.identifier.authority | Wong, DKH=rp00492 | - |
dc.identifier.authority | Fung, J=rp00518 | - |
dc.identifier.authority | Seto, WK=rp01659 | - |
dc.identifier.authority | Lai, CL=rp00314 | - |
dc.identifier.authority | Yuen, MF=rp00479 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/liv.13372 | - |
dc.identifier.pmid | 28111892 | - |
dc.identifier.scopus | eid_2-s2.0-85012918924 | - |
dc.identifier.hkuros | 271884 | - |
dc.identifier.volume | 37 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1287 | - |
dc.identifier.epage | 1294 | - |
dc.identifier.isi | WOS:000408482200005 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1478-3223 | - |