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Article: A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes

TitleA-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
Authors
Issue Date2017
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2017, v. 8, p. 14147:1-16 How to Cite?
AbstractThe adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications. Here we show that A-FABP increases thermogenesis by promoting the conversion of T4 to T3 in brown adipocytes. We find that A-FABP levels are increased in both white (WAT) and brown (BAT) adipose tissues and the bloodstream in response to thermogenic stimuli. A-FABP knockout mice have reduced thermogenesis and whole-body energy expenditure after cold stress or after feeding a high-fat diet, which can be reversed by infusion of recombinant A-FABP. Mechanistically, A-FABP induces the expression of type-II iodothyronine deiodinase in BAT via inhibition of the nuclear receptor liver X receptor α, thereby leading to the conversion of thyroid hormone from its inactive form T4 to active T3. The thermogenic responses to T4 are abrogated in A-FABP KO mice, but enhanced by A-FABP. Thus, A-FABP acts as a physiological stimulator of BAT-mediated adaptive thermogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/238677
ISSN
2017 Impact Factor: 12.353
2015 SCImago Journal Rankings: 6.539
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSHU, L-
dc.contributor.authorHoo, RLC-
dc.contributor.authorWU, X-
dc.contributor.authorPAN, Y-
dc.contributor.authorLEE, PC-
dc.contributor.authorCHEONG, LY-
dc.contributor.authorBornstein, SR-
dc.contributor.authorRong, X-
dc.contributor.authorGua, J-
dc.contributor.authorXu, A-
dc.date.accessioned2017-02-20T01:24:39Z-
dc.date.available2017-02-20T01:24:39Z-
dc.date.issued2017-
dc.identifier.citationNature Communications, 2017, v. 8, p. 14147:1-16-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/238677-
dc.description.abstractThe adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications. Here we show that A-FABP increases thermogenesis by promoting the conversion of T4 to T3 in brown adipocytes. We find that A-FABP levels are increased in both white (WAT) and brown (BAT) adipose tissues and the bloodstream in response to thermogenic stimuli. A-FABP knockout mice have reduced thermogenesis and whole-body energy expenditure after cold stress or after feeding a high-fat diet, which can be reversed by infusion of recombinant A-FABP. Mechanistically, A-FABP induces the expression of type-II iodothyronine deiodinase in BAT via inhibition of the nuclear receptor liver X receptor α, thereby leading to the conversion of thyroid hormone from its inactive form T4 to active T3. The thermogenic responses to T4 are abrogated in A-FABP KO mice, but enhanced by A-FABP. Thus, A-FABP acts as a physiological stimulator of BAT-mediated adaptive thermogenesis.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleA-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes-
dc.typeArticle-
dc.identifier.emailHoo, RLC: rubyhoo@hkucc.hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.authorityHoo, RLC=rp01334-
dc.identifier.authorityXu, A=rp00485-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/ncomms14147-
dc.identifier.hkuros271454-
dc.identifier.volume8-
dc.identifier.spage14147:1-
dc.identifier.epage16-
dc.identifier.isiWOS:000392742100001-
dc.publisher.placeUnited Kingdom-

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