A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention


Grant Data
Project Title
A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Principal Investigator
Professor Xu, Aimin   (Project coordinator)
Co-Investigator(s)
Professor Huang Yu   (Co-principal investigator)
Dr Wang Yu   (Co-principal investigator)
Dr Cheng King Yip   (Co-principal investigator)
Professor Lam Karen Siu Ling   (Co-principal investigator)
Professor Vanhoutte Paul Michel Georges Remi   (Co-principal investigator)
Professor Wu Ed Xuekui   (Co-principal investigator)
Dr Woo Wai Hong Connie   (Co-principal investigator)
Duration
36
Start Date
2015-06-20
Completion Date
2018-06-19
Amount
8780850
Conference Title
Presentation Title
Keywords
Atherosclerosis, Adipose tissue inflammation, Immunometabolism, Macrophage polarization, Adipokines
Discipline
Cardiovascular Research,Diabetes/Metabolism
Panel
Medicine
Sponsor
RGC Collaborative Research Fund (CRF)
HKU Project Code
C7055-14G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project
Funding Year
2014/2015
Status
On-going
Objectives
dysfunction and atherosclerosis in rodents and humans; 2) To investigate the molecular mechanism by which miR-34a and miR-883b fine-tunes macrophage infiltration and polarization in adipose tissues; 3) To elucidate how the two small lipid-binding adipokines (A-FABP and lipocalin-2) mediate obesity-induced M2→M1 macrophage polarization and vascular dysfunction in rodents; 4) To validate whether A-FABP and lipocalin-2 are viable therapeutic targets for obesityinduced adipose inflammation, endothelial dysfunction and atherosclerosis in pigs.