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Article: Diffusion-perfusion mismatch in single subcortical infarction: A predictor of early neurological deterioration and poor functional outcome

TitleDiffusion-perfusion mismatch in single subcortical infarction: A predictor of early neurological deterioration and poor functional outcome
Authors
KeywordsPrognosis
Single subcortical infarction
Diffusion-perfusion mismatch
Neurological deterioration
Issue Date2015
Citation
European Neurology, 2015, v. 73, n. 5-6, p. 353-359 How to Cite?
Abstract© 2015 S. Karger AG, Basel.Background/Aims: Early neurological deterioration (END) is frequently observed and related to poor functional outcome in patients with single subcortical infarction (SSI). We evaluated the role of diffusion-perfusion mismatch (DPM) as a predictor of END and functional outcome in patients with SSI. Methods: We retrospectively analyzed data for 274 patients with acute SSI. DPM was positive in the presence of a lesion on the perfusion map that was larger than that on the corresponding slice on diffusion-weighted imaging. END was defined as an increase of <1 points in the motor portion of the National Institute of Health Stroke Scale (NIHSS) within 72 h from MRI acquisition. Patients with a modified Rankin Scale (mRS) score of 3 or more at day 30 were considered having a poor functional outcome. Results: DPM was more frequently observed in the END (+) than in the END (-) group (21/35 (60.0%) vs. 50/239 (20.9%); p < 0.001). After adjusting for covariates, the presence of DPM and NIHSS score on admission were independently associated with END (DPM, OR 5.03, p < 0.001; NIHSS, OR 1.14, p = 0.033) and poor functional outcome (DPM, OR 2.44, p = 0.018; NIHSS, OR 1.48, p < 0.001). Conclusions: The DPM concept is applicable to prediction of END and functional disability in patients with SSI.
Persistent Identifierhttp://hdl.handle.net/10722/238135
ISSN
2015 Impact Factor: 1.403
2015 SCImago Journal Rankings: 0.659

 

DC FieldValueLanguage
dc.contributor.authorKim, Jun Pyo-
dc.contributor.authorKim, Suk Jae-
dc.contributor.authorLee, Jung Jae-
dc.contributor.authorCha, Ji Hoon-
dc.contributor.authorBang, Oh Young-
dc.contributor.authorChung, Chin Sang-
dc.contributor.authorLee, Kwang Ho-
dc.contributor.authorKim, Gyeong Moon-
dc.date.accessioned2017-02-03T02:13:09Z-
dc.date.available2017-02-03T02:13:09Z-
dc.date.issued2015-
dc.identifier.citationEuropean Neurology, 2015, v. 73, n. 5-6, p. 353-359-
dc.identifier.issn0014-3022-
dc.identifier.urihttp://hdl.handle.net/10722/238135-
dc.description.abstract© 2015 S. Karger AG, Basel.Background/Aims: Early neurological deterioration (END) is frequently observed and related to poor functional outcome in patients with single subcortical infarction (SSI). We evaluated the role of diffusion-perfusion mismatch (DPM) as a predictor of END and functional outcome in patients with SSI. Methods: We retrospectively analyzed data for 274 patients with acute SSI. DPM was positive in the presence of a lesion on the perfusion map that was larger than that on the corresponding slice on diffusion-weighted imaging. END was defined as an increase of <1 points in the motor portion of the National Institute of Health Stroke Scale (NIHSS) within 72 h from MRI acquisition. Patients with a modified Rankin Scale (mRS) score of 3 or more at day 30 were considered having a poor functional outcome. Results: DPM was more frequently observed in the END (+) than in the END (-) group (21/35 (60.0%) vs. 50/239 (20.9%); p < 0.001). After adjusting for covariates, the presence of DPM and NIHSS score on admission were independently associated with END (DPM, OR 5.03, p < 0.001; NIHSS, OR 1.14, p = 0.033) and poor functional outcome (DPM, OR 2.44, p = 0.018; NIHSS, OR 1.48, p < 0.001). Conclusions: The DPM concept is applicable to prediction of END and functional disability in patients with SSI.-
dc.languageeng-
dc.relation.ispartofEuropean Neurology-
dc.subjectPrognosis-
dc.subjectSingle subcortical infarction-
dc.subjectDiffusion-perfusion mismatch-
dc.subjectNeurological deterioration-
dc.titleDiffusion-perfusion mismatch in single subcortical infarction: A predictor of early neurological deterioration and poor functional outcome-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000430461-
dc.identifier.pmid26021692-
dc.identifier.scopuseid_2-s2.0-84930246214-
dc.identifier.volume73-
dc.identifier.issue5-6-
dc.identifier.spage353-
dc.identifier.epage359-
dc.identifier.eissn1421-9913-

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