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- Publisher Website: 10.1016/j.ahj.2016.07.021
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Article: Effect of L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine on ischemic heart disease risk: A Mendelian randomization study
Title | Effect of L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine on ischemic heart disease risk: A Mendelian randomization study |
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Authors | |
Issue Date | 2016 |
Citation | American Heart Journal, 2016, v. 182, p. 54-61 How to Cite? |
Abstract | © 2016Background L-arginine is a commonly consumed dietary conditional essential amino acid found in food items and supplements, which is closely related to asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). L-arginine is thought to increase nitric oxide and be cardioprotective, whereas ADMA and SDMA may inhibit nitric oxide synthesis and increase cardiovascular disease risk. Unexpectedly, L-arginine increased mortality in a small trial. To clarify the effects of these potential targets of intervention, we assessed the risk of ischemic heart disease (IHD) by genetically determined L-arginine, ADMA, and SDMA. Methods Single nucleotide polymorphisms (SNPs) contributing to L-arginine, ADMA, and SDMA, at genome-wide significance, were applied to the CARDIoGRAMplusC4D 1000 Genomes–based genome-wide association study IHD case (n = 60,801, ~70% myocardial infarction)-control (n = 123,504) study. We obtained unconfounded estimates using instrumental variable analysis by combining the Wald estimators for each SNP, taking into account any correlation between SNPs using weighted generalized linear regression. Results Higher L-arginine was associated with higher risk of IHD (odds ratio [OR] 1.18 per SD increase, 95% CI 1.03-1.36) and of myocardial infarction (OR 1.29, 95% CI 1.10-1.51), based on 2 SNPs from MED23. Symmetric dimethylarginine had an OR of 1.07 per SD (95% CI 0.99-1.17) for IHD based on 5 SNPs from AGXT2. Asymmetric dimethylarginine had and OR of 1.08 per SD (95% CI 0.99-1.19) for IHD based on 4 SNPs from DDAH1. Conclusion L-arginine could possibly cause IHD. Given that L-arginine occurs in many common dietary items, investigation of its health effect is required. |
Persistent Identifier | http://hdl.handle.net/10722/236629 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 2.109 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Au Yeung, Shiu Lun | - |
dc.contributor.author | Lin, Shi Lin | - |
dc.contributor.author | Lam, Hung San Hugh Simon | - |
dc.contributor.author | Schooling, Catherine Mary | - |
dc.date.accessioned | 2016-12-01T09:08:27Z | - |
dc.date.available | 2016-12-01T09:08:27Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | American Heart Journal, 2016, v. 182, p. 54-61 | - |
dc.identifier.issn | 0002-8703 | - |
dc.identifier.uri | http://hdl.handle.net/10722/236629 | - |
dc.description.abstract | © 2016Background L-arginine is a commonly consumed dietary conditional essential amino acid found in food items and supplements, which is closely related to asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). L-arginine is thought to increase nitric oxide and be cardioprotective, whereas ADMA and SDMA may inhibit nitric oxide synthesis and increase cardiovascular disease risk. Unexpectedly, L-arginine increased mortality in a small trial. To clarify the effects of these potential targets of intervention, we assessed the risk of ischemic heart disease (IHD) by genetically determined L-arginine, ADMA, and SDMA. Methods Single nucleotide polymorphisms (SNPs) contributing to L-arginine, ADMA, and SDMA, at genome-wide significance, were applied to the CARDIoGRAMplusC4D 1000 Genomes–based genome-wide association study IHD case (n = 60,801, ~70% myocardial infarction)-control (n = 123,504) study. We obtained unconfounded estimates using instrumental variable analysis by combining the Wald estimators for each SNP, taking into account any correlation between SNPs using weighted generalized linear regression. Results Higher L-arginine was associated with higher risk of IHD (odds ratio [OR] 1.18 per SD increase, 95% CI 1.03-1.36) and of myocardial infarction (OR 1.29, 95% CI 1.10-1.51), based on 2 SNPs from MED23. Symmetric dimethylarginine had an OR of 1.07 per SD (95% CI 0.99-1.17) for IHD based on 5 SNPs from AGXT2. Asymmetric dimethylarginine had and OR of 1.08 per SD (95% CI 0.99-1.19) for IHD based on 4 SNPs from DDAH1. Conclusion L-arginine could possibly cause IHD. Given that L-arginine occurs in many common dietary items, investigation of its health effect is required. | - |
dc.language | eng | - |
dc.relation.ispartof | American Heart Journal | - |
dc.title | Effect of L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine on ischemic heart disease risk: A Mendelian randomization study | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ahj.2016.07.021 | - |
dc.identifier.scopus | eid_2-s2.0-84988953740 | - |
dc.identifier.hkuros | 275983 | - |
dc.identifier.volume | 182 | - |
dc.identifier.spage | 54 | - |
dc.identifier.epage | 61 | - |
dc.identifier.eissn | 1097-6744 | - |
dc.identifier.isi | WOS:000389136600007 | - |
dc.identifier.issnl | 0002-8703 | - |