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Article: Preexisting Antibody-Dependent Cellular Cytotoxicity–Activating Antibody Responses Are Stable Longitudinally and Cross-reactive Responses Are Not Boosted by Recent Influenza Exposure

TitlePreexisting Antibody-Dependent Cellular Cytotoxicity–Activating Antibody Responses Are Stable Longitudinally and Cross-reactive Responses Are Not Boosted by Recent Influenza Exposure
Authors
Issue Date2016
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/
Citation
Journal of Infectious Diseases, 2016, v. 214 n. 8, p. 1159-1163 How to Cite?
AbstractCross-reactive influenza virus-specific antibody-dependent cellular cytotoxicity (ADCC)-activating antibodies are readily detected in healthy adults. However, little is known about the kinetics of these ADCC responses. We used retrospective serial blood samples from healthy donors to investigate this topic. All donors had ADCC responses against 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) and avian influenza A(H7N9) virus hemagglutinins (HAs) despite being seronegative for these viruses in standard hemagglutination inhibition and microneutralization serological assays. A(H1N1)pdm09 exposure did not boost ADCC responses specific for H7 HA antigens. H7 HA ADCC responses were variable longitudinally within donors, suggesting that these cross-reactive antibodies are unstable. We found no correlation between ADCC responses to the H7 HA and either influenza virus-specific immunoglobulin G1 concentration or age.
Persistent Identifierhttp://hdl.handle.net/10722/236525
ISSN
2017 Impact Factor: 5.186
2015 SCImago Journal Rankings: 4.000
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDoak, SA-
dc.contributor.authorZhang, Y-
dc.contributor.authorChan, KY-
dc.contributor.authorLeung, SM-
dc.contributor.authorWu, JTK-
dc.contributor.authorPoon, LML-
dc.date.accessioned2016-11-25T00:54:36Z-
dc.date.available2016-11-25T00:54:36Z-
dc.date.issued2016-
dc.identifier.citationJournal of Infectious Diseases, 2016, v. 214 n. 8, p. 1159-1163-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/236525-
dc.description.abstractCross-reactive influenza virus-specific antibody-dependent cellular cytotoxicity (ADCC)-activating antibodies are readily detected in healthy adults. However, little is known about the kinetics of these ADCC responses. We used retrospective serial blood samples from healthy donors to investigate this topic. All donors had ADCC responses against 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) and avian influenza A(H7N9) virus hemagglutinins (HAs) despite being seronegative for these viruses in standard hemagglutination inhibition and microneutralization serological assays. A(H1N1)pdm09 exposure did not boost ADCC responses specific for H7 HA antigens. H7 HA ADCC responses were variable longitudinally within donors, suggesting that these cross-reactive antibodies are unstable. We found no correlation between ADCC responses to the H7 HA and either influenza virus-specific immunoglobulin G1 concentration or age.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/-
dc.relation.ispartofJournal of Infectious Diseases-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titlePreexisting Antibody-Dependent Cellular Cytotoxicity–Activating Antibody Responses Are Stable Longitudinally and Cross-reactive Responses Are Not Boosted by Recent Influenza Exposure-
dc.typeArticle-
dc.identifier.emailDoak, SA: sophiev@hku.hk-
dc.identifier.emailChan, KY: ichan2@hku.hk-
dc.identifier.emailWu, JTK: joewu@hku.hk-
dc.identifier.emailPoon, LML: llmpoon@hkucc.hku.hk-
dc.identifier.authorityDoak, SA=rp02141-
dc.identifier.authorityWu, JTK=rp00517-
dc.identifier.authorityPoon, LML=rp00484-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/infdis/jiw346-
dc.identifier.pmcidPMC5034955-
dc.identifier.scopuseid_2-s2.0-84990909246-
dc.identifier.hkuros270633-
dc.identifier.hkuros287717-
dc.identifier.volume214-
dc.identifier.issue8-
dc.identifier.spage1159-
dc.identifier.epage1163-
dc.identifier.isiWOS:000386147200008-
dc.publisher.placeUnited States-

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