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Conference Paper: Imaging and mapping individual target proteins on clinical lymphoma cells by AFM

TitleImaging and mapping individual target proteins on clinical lymphoma cells by AFM
Authors
Issue Date2015
PublisherI EEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1800098
Citation
The 9th IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2015), Waikiki Beach,Honolulu, HI., 15-18 November 2015. In Conference Proceedings, 2015, p. 84-87 How to Cite?
AbstractThe wide applications of atomic force microscopy (AFM) in the past decade have contributed much to the field of cell biology, providing a lot of novel insights into cellular behaviors at the nanoscale. However, current AFM studies are commonly performed on cell lines cultured in vitro which are quite different from the cells in the human body. Directly investigating the physiological activities on tumor cells from clinical patients is of great significance for helping us to better understand the actual cellular activities taking place in the clinical environment. Under the fluorescence recognition of specific tumor cell surface marker, we have used AFM to investigate the binding affinity and nanoscale distributions of CD20 target protein directly on tumor cells prepared from the bone marrow of lymphoma patients. The results provide a new idea to develop closer links between laboratory study and clinical practice, which may have potential impacts on diverse fields such as drug evaluation and efficacy prediction. © 2015 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/235004
ISBN

 

DC FieldValueLanguage
dc.contributor.authorLi, M-
dc.contributor.authorLiu, L-
dc.contributor.authorXi, N-
dc.contributor.authorWang, Y-
dc.contributor.authorWang, W-
dc.date.accessioned2016-10-14T13:50:39Z-
dc.date.available2016-10-14T13:50:39Z-
dc.date.issued2015-
dc.identifier.citationThe 9th IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED 2015), Waikiki Beach,Honolulu, HI., 15-18 November 2015. In Conference Proceedings, 2015, p. 84-87-
dc.identifier.isbn978-146739671-4-
dc.identifier.urihttp://hdl.handle.net/10722/235004-
dc.description.abstractThe wide applications of atomic force microscopy (AFM) in the past decade have contributed much to the field of cell biology, providing a lot of novel insights into cellular behaviors at the nanoscale. However, current AFM studies are commonly performed on cell lines cultured in vitro which are quite different from the cells in the human body. Directly investigating the physiological activities on tumor cells from clinical patients is of great significance for helping us to better understand the actual cellular activities taking place in the clinical environment. Under the fluorescence recognition of specific tumor cell surface marker, we have used AFM to investigate the binding affinity and nanoscale distributions of CD20 target protein directly on tumor cells prepared from the bone marrow of lymphoma patients. The results provide a new idea to develop closer links between laboratory study and clinical practice, which may have potential impacts on diverse fields such as drug evaluation and efficacy prediction. © 2015 IEEE.-
dc.languageeng-
dc.publisherI EEE. The Journal's web site is located at http://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1800098-
dc.relation.ispartofIEEE International Conference on Nano/Molecular Medicine and Engineering Proceedings-
dc.rightsIEEE International Conference on Nano/Molecular Medicine and Engineering Proceedings. Copyright © IEEE.-
dc.rights©2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.-
dc.titleImaging and mapping individual target proteins on clinical lymphoma cells by AFM-
dc.typeConference_Paper-
dc.identifier.emailXi, N: xining@hku.hk-
dc.identifier.authorityXi, N=rp02044-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1109/NANOMED.2015.7492507-
dc.identifier.scopuseid_2-s2.0-84979243394-
dc.identifier.hkuros269334-
dc.identifier.spage84-
dc.identifier.epage87-
dc.publisher.placeUnited States-
dc.customcontrol.immutablesml 161018-

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