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Article: Association of variability in hemoglobin A1c with cardiovascular diseases and mortality in Chinese patients with type 2 diabetes mellitus — A retrospective population-based cohort study

TitleAssociation of variability in hemoglobin A1c with cardiovascular diseases and mortality in Chinese patients with type 2 diabetes mellitus — A retrospective population-based cohort study
Authors
KeywordsDiabetes mellitus
HbA1c
Variability
Cardiovascular diseases
Mortality
Issue Date2016
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jdiacomp
Citation
Journal of Diabetes and its Complications, 2016, v. 30 n. 7, p. 1240-1247 How to Cite?
AbstractAims: This study aimed to investigate the association between variability in HbA1c and incidence of cardiovascular disease (CVD) event and mortality among Chinese primary care patients with Type 2 diabetes mellitus (T2DM). Methods: A retrospective cohort study was conducted on 91,866 T2DM patients aged ≥ 18 years without any history of CVD. Variability in HbA1c, was measured by standard deviation (SD), associated with the risks of CVD and all-cause mortality were evaluated using Cox proportional hazards regression analysis by age groups ( 65 and ≥ 65 years old).' to 'Variability in HbA1c was measured by standard deviation (SD) The association between Variability in HbA1c and the incidence of CVD and all-cause mortality were evaluated using Cox proportional hazards regression analysis by age groups ( 65 and ≥ 65 years old). Results: Over a median follow-up of 58.5 months, our study identified a positive linear relationship between variability in HbA1c and incidence of CVD and all-cause mortality in the younger and older groups. For every 1-SD increase in HbA1c, the risk of CVD events in the older group only increased by 15.2% (95% CI: 1.026–1.293), and the risks of all-cause mortality in both age groups increased by 49.5% (95% CI: 1.154–1.936) and 77.8% (95% CI: 1.563–2.024), respectively. Conclusions: The HbA1c variability independently of the mean HbA1c level may provide additional valuable information as a potential predictor for the development of CVD and all-cause mortality in diabetic patients, particularly for the elderly patients.
Persistent Identifierhttp://hdl.handle.net/10722/234686
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 1.018
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWan, YF-
dc.contributor.authorFung, SCC-
dc.contributor.authorFong, DYT-
dc.contributor.authorLam, CLK-
dc.date.accessioned2016-10-14T13:48:29Z-
dc.date.available2016-10-14T13:48:29Z-
dc.date.issued2016-
dc.identifier.citationJournal of Diabetes and its Complications, 2016, v. 30 n. 7, p. 1240-1247-
dc.identifier.issn1056-8727-
dc.identifier.urihttp://hdl.handle.net/10722/234686-
dc.description.abstractAims: This study aimed to investigate the association between variability in HbA1c and incidence of cardiovascular disease (CVD) event and mortality among Chinese primary care patients with Type 2 diabetes mellitus (T2DM). Methods: A retrospective cohort study was conducted on 91,866 T2DM patients aged ≥ 18 years without any history of CVD. Variability in HbA1c, was measured by standard deviation (SD), associated with the risks of CVD and all-cause mortality were evaluated using Cox proportional hazards regression analysis by age groups ( 65 and ≥ 65 years old).' to 'Variability in HbA1c was measured by standard deviation (SD) The association between Variability in HbA1c and the incidence of CVD and all-cause mortality were evaluated using Cox proportional hazards regression analysis by age groups ( 65 and ≥ 65 years old). Results: Over a median follow-up of 58.5 months, our study identified a positive linear relationship between variability in HbA1c and incidence of CVD and all-cause mortality in the younger and older groups. For every 1-SD increase in HbA1c, the risk of CVD events in the older group only increased by 15.2% (95% CI: 1.026–1.293), and the risks of all-cause mortality in both age groups increased by 49.5% (95% CI: 1.154–1.936) and 77.8% (95% CI: 1.563–2.024), respectively. Conclusions: The HbA1c variability independently of the mean HbA1c level may provide additional valuable information as a potential predictor for the development of CVD and all-cause mortality in diabetic patients, particularly for the elderly patients.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jdiacomp-
dc.relation.ispartofJournal of Diabetes and its Complications-
dc.subjectDiabetes mellitus-
dc.subjectHbA1c-
dc.subjectVariability-
dc.subjectCardiovascular diseases-
dc.subjectMortality-
dc.titleAssociation of variability in hemoglobin A1c with cardiovascular diseases and mortality in Chinese patients with type 2 diabetes mellitus — A retrospective population-based cohort study-
dc.typeArticle-
dc.identifier.emailWan, YF: yfwan@hku.hk-
dc.identifier.emailFung, SCC: cfsc@hku.hk-
dc.identifier.emailFong, DYT: dytfong@hku.hk-
dc.identifier.emailLam, CLK: clklam@hku.hk-
dc.identifier.authorityWan, YF=rp02518-
dc.identifier.authorityFung, SCC=rp01330-
dc.identifier.authorityFong, DYT=rp00253-
dc.identifier.authorityLam, CLK=rp00350-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jdiacomp.2016.05.024-
dc.identifier.pmid27318537-
dc.identifier.scopuseid_2-s2.0-84990950517-
dc.identifier.hkuros269988-
dc.identifier.volume30-
dc.identifier.issue7-
dc.identifier.spage1240-
dc.identifier.epage1247-
dc.identifier.isiWOS:000382097600007-
dc.publisher.placeUnited States-
dc.identifier.issnl1056-8727-

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