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Conference Paper: Wide resection margin improves survival in patients with early intrahepatic cholangiocarcinoma - a 22-year single center experience

TitleWide resection margin improves survival in patients with early intrahepatic cholangiocarcinoma - a 22-year single center experience
Authors
Issue Date2016
PublisherS. Karger AG. The Journal's web site is located at http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=255487
Citation
The 7th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2016), Hong Kong, China, 8-10 July 2016. In Liver Cancer, 2016, v. 5 suppl. 1, p. 73, abstract no. 0112 How to Cite?
AbstractOBJECTIVES: Prognosis of Intrahepatic Cholangiocarcinoma (ICC) remained poor despite the multitude advancement of medical care. Resection margin status is one of the few modifiable factors that a surgeon could possibly manipulate to alter the disease outcome. However, the significance of margin status and margin width is still controversial. This study serves to further elucidate the role of them. METHOD: This is a retrospective cohort from the Queen Mary Hospital, The University of Hong Kong. Consecutive patients diagnosed to have ICC and with surgical resection performed in curative intent were retrieved, while patients with cholangiohepatocellular carcinoma, Klaskin tumour, tumour of extrahepatic bile duct and uncertain tumour pathology were excluded. RESULTS: From 1991 to 2013, there were 107 patients underwent hepatectomy for ICC. Gender predilection was not observed with 58 males and 49 females, median age of the patients was 61. The median tumour size was 6 cm and most of them (43%) were moderately differentiated adenocarcinoma adenocarcinoma. Clear resection margin were achieved in 95 patients (88.8%) and the median margin width was 0.5 cm. The Hospital length of stay and operative mortality were eleven days and 3% respectively. The disease free survival and overall survival was 17.5 months and 25.1 months respectively. Multivariate analysis showed that margin width was an independent factor associated with disease free survival (P = 0.015, 95% C.I. 0.4–0.9). Sub-group analysis in patients with solitary tumour showed that margin width is an independent factor affecting overall survival (P = 0.048 OR 0.577 95% CI 0.334–0.996). Discriminant analysis showed that the overall survival increased from 36 months to 185 months when margin width was greater than 0.9 cm (p = 0.025) in patients with solitary tumour. CONCLUSION: Aggressive resection to achieve resection margin of at least 1 cm maximizes chance of cure in patients with early ICC.
DescriptionSession - Surgery, Transplantation
This journal suppl. entitled: The 7th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2016). Advancing HCC Management through Multi-Disciplinary Approach. Hong Kong, SAR (China), July 8-10, 2016: Abstracts
Persistent Identifierhttp://hdl.handle.net/10722/232543
ISSN

 

DC FieldValueLanguage
dc.contributor.authorMa, KW-
dc.contributor.authorCheung, TT-
dc.contributor.authorShe, WH-
dc.contributor.authorChok, KSH-
dc.contributor.authorChan, ACY-
dc.contributor.authorNg, IOL-
dc.contributor.authorChan, SC-
dc.contributor.authorLo, CM-
dc.contributor.authorPoon, RTP-
dc.date.accessioned2016-09-20T05:30:45Z-
dc.date.available2016-09-20T05:30:45Z-
dc.date.issued2016-
dc.identifier.citationThe 7th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2016), Hong Kong, China, 8-10 July 2016. In Liver Cancer, 2016, v. 5 suppl. 1, p. 73, abstract no. 0112-
dc.identifier.issn2235-1795-
dc.identifier.urihttp://hdl.handle.net/10722/232543-
dc.descriptionSession - Surgery, Transplantation-
dc.descriptionThis journal suppl. entitled: The 7th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2016). Advancing HCC Management through Multi-Disciplinary Approach. Hong Kong, SAR (China), July 8-10, 2016: Abstracts-
dc.description.abstractOBJECTIVES: Prognosis of Intrahepatic Cholangiocarcinoma (ICC) remained poor despite the multitude advancement of medical care. Resection margin status is one of the few modifiable factors that a surgeon could possibly manipulate to alter the disease outcome. However, the significance of margin status and margin width is still controversial. This study serves to further elucidate the role of them. METHOD: This is a retrospective cohort from the Queen Mary Hospital, The University of Hong Kong. Consecutive patients diagnosed to have ICC and with surgical resection performed in curative intent were retrieved, while patients with cholangiohepatocellular carcinoma, Klaskin tumour, tumour of extrahepatic bile duct and uncertain tumour pathology were excluded. RESULTS: From 1991 to 2013, there were 107 patients underwent hepatectomy for ICC. Gender predilection was not observed with 58 males and 49 females, median age of the patients was 61. The median tumour size was 6 cm and most of them (43%) were moderately differentiated adenocarcinoma adenocarcinoma. Clear resection margin were achieved in 95 patients (88.8%) and the median margin width was 0.5 cm. The Hospital length of stay and operative mortality were eleven days and 3% respectively. The disease free survival and overall survival was 17.5 months and 25.1 months respectively. Multivariate analysis showed that margin width was an independent factor associated with disease free survival (P = 0.015, 95% C.I. 0.4–0.9). Sub-group analysis in patients with solitary tumour showed that margin width is an independent factor affecting overall survival (P = 0.048 OR 0.577 95% CI 0.334–0.996). Discriminant analysis showed that the overall survival increased from 36 months to 185 months when margin width was greater than 0.9 cm (p = 0.025) in patients with solitary tumour. CONCLUSION: Aggressive resection to achieve resection margin of at least 1 cm maximizes chance of cure in patients with early ICC.-
dc.languageeng-
dc.publisherS. Karger AG. The Journal's web site is located at http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=255487-
dc.relation.ispartofLiver Cancer-
dc.rightsLiver Cancer. Copyright © S. Karger AG.-
dc.titleWide resection margin improves survival in patients with early intrahepatic cholangiocarcinoma - a 22-year single center experience-
dc.typeConference_Paper-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailShe, WH: brianshe@hku.hk-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailNg, IOL: iolng@hku.hk-
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailPoon, RTP: poontp@hku.hk-
dc.identifier.authorityCheung, TT=rp02129-
dc.identifier.authorityChok, KSH=rp02110-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityNg, IOL=rp00335-
dc.identifier.authorityChan, SC=rp01568-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityPoon, RTP=rp00446-
dc.identifier.hkuros264090-
dc.identifier.volume5-
dc.identifier.issuesuppl. 1-
dc.identifier.spage73, abstract no. 0112-
dc.identifier.epage73, abstract no. 0112-
dc.publisher.placeSwitzerland-

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