File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL

Conference Paper: Evaluation of cutoffs for low lean mass and slow gait speed in predicting death in the National Health and Nutrition Examination Survey 1999-2004

TitleEvaluation of cutoffs for low lean mass and slow gait speed in predicting death in the National Health and Nutrition Examination Survey 1999-2004
Authors
Issue Date2016
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
The 21st Medical Research Conference (MRC 2016), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 June 2016. In Hong Kong Medical Journal, 2016, v. 22 suppl. 1, p. 17, abstract no. 15 How to Cite?
AbstractINTRODUCTION: Sarcopenia is commonly defined as loss of muscle mass with limited muscle function or strength. Different cutoffs of low lean mass and slow gait speed have been proposed by different professional working groups. We compared the performance of different cutoffs of low lean mass and slow gait speed in predicting death. METHODS: We analysed data of participants aged 65 years or older from the continuous National Health and Nutrition Examination Survey 1999-2004 (n=2841), and the subsequent follow-up data on mortality up to 31 December 2006. For low lean mass, cutoffs based on appendicular lean mass (ALM) alone, ALM adjusted for body mass index (ALMBMI), and ALM adjusted for height squared (ALMH2) were evaluated. For slow gait speed, the cutoffs based on 0.8 and 1.0 m/s were evaluated. A cox-proportional hazard regression model with adjustment for multiple confounding factors was used for the association analyses. RESULTS: For low lean mass, the cutoffs based on ALMBMI ( < 0.512 in women and < 0.789 in men) showed the most significant association and highest hazard ratio with death (hazard ratio=1.72; 95% confidence interval [CI], 1.28- 2.29). For slow gait speed, all cutoffs tested showed significant association with death in the full model (P < 0.001), while the cutoff of 0.8 m/s showed the highest hazard ratio (2.32; 95% CI, 1.58-3.39). CONCLUSIONS: Low lean mass defined by ALMBMI showed the strongest association with death; while slow gait speed showed significant association with death, with the strongest association being observed for the cutoff of 0.8 m/s. Further studies validating the cutoffs are warranted before using them in clinical settings.
Persistent Identifierhttp://hdl.handle.net/10722/232468
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorCheung, CL-
dc.contributor.authorLam, KSL-
dc.contributor.authorCheung, BMY-
dc.date.accessioned2016-09-20T05:30:12Z-
dc.date.available2016-09-20T05:30:12Z-
dc.date.issued2016-
dc.identifier.citationThe 21st Medical Research Conference (MRC 2016), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 June 2016. In Hong Kong Medical Journal, 2016, v. 22 suppl. 1, p. 17, abstract no. 15-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/232468-
dc.description.abstractINTRODUCTION: Sarcopenia is commonly defined as loss of muscle mass with limited muscle function or strength. Different cutoffs of low lean mass and slow gait speed have been proposed by different professional working groups. We compared the performance of different cutoffs of low lean mass and slow gait speed in predicting death. METHODS: We analysed data of participants aged 65 years or older from the continuous National Health and Nutrition Examination Survey 1999-2004 (n=2841), and the subsequent follow-up data on mortality up to 31 December 2006. For low lean mass, cutoffs based on appendicular lean mass (ALM) alone, ALM adjusted for body mass index (ALMBMI), and ALM adjusted for height squared (ALMH2) were evaluated. For slow gait speed, the cutoffs based on 0.8 and 1.0 m/s were evaluated. A cox-proportional hazard regression model with adjustment for multiple confounding factors was used for the association analyses. RESULTS: For low lean mass, the cutoffs based on ALMBMI ( < 0.512 in women and < 0.789 in men) showed the most significant association and highest hazard ratio with death (hazard ratio=1.72; 95% confidence interval [CI], 1.28- 2.29). For slow gait speed, all cutoffs tested showed significant association with death in the full model (P < 0.001), while the cutoff of 0.8 m/s showed the highest hazard ratio (2.32; 95% CI, 1.58-3.39). CONCLUSIONS: Low lean mass defined by ALMBMI showed the strongest association with death; while slow gait speed showed significant association with death, with the strongest association being observed for the cutoff of 0.8 m/s. Further studies validating the cutoffs are warranted before using them in clinical settings.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleEvaluation of cutoffs for low lean mass and slow gait speed in predicting death in the National Health and Nutrition Examination Survey 1999-2004-
dc.typeConference_Paper-
dc.identifier.emailCheung, CL: lung1212@hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailCheung, BMY: mycheung@hkucc.hku.hk-
dc.identifier.authorityCheung, CL=rp01749-
dc.identifier.authorityLam, KSL=rp00343-
dc.identifier.authorityCheung, BMY=rp01321-
dc.identifier.hkuros265888-
dc.identifier.volume22-
dc.identifier.issuesuppl. 1-
dc.identifier.spage17, abstract no. 15-
dc.identifier.epage17, abstract no. 15-
dc.publisher.placeHong Kong-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats