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Conference Paper: Relationship between diabetic retinopathy and subclinical myocardial dysfunction in patients with diabetic mellitus

TitleRelationship between diabetic retinopathy and subclinical myocardial dysfunction in patients with diabetic mellitus
Authors
Issue Date2015
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
The 20th Medical Research Conference (MRC 2015), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 17 January 2015. In Hong Kong Medical Journal, 2015, v. 21 suppl. 1, p. 61, abstract no. 103 How to Cite?
AbstractBACKGROUND: Type 2 diabetes mellitus (T2DM) complicated by retinopathy is associated with impaired left ventricular (LV) structure and resting myocardial dysfunction. The myocardial response to stress has not been compared in patients with and without diabetic retinopathy. METHODS: A total of 134 parents with T2DM without any history of cardiovascular disease were recruited. All patients underwent detailed retinal photography to screen for diabetic retinopathy, resting and exercise echocardiography. Resting echocardiography was analysed by (1) conventional echocardiographic parameters and (2) speckle tracking derived global longitudinal strain (GLS). Exercise echocardiography parameters included diastolic function reserve index (DFRI) and stress GLS. RESULTS: A total of 43 (23%) patients had retinopathy. For resting echocardiography, both LV dimension and LV ejection fraction were similar between patients with and without diabetic retinopathy. However, patients with retinopathy had a significantly impaired GLS, higher prevalence of diastolic dysfunction, a higher E/E’ ratio (LV filling pressure) compared with patients without retinopathy. Stress echocardiography also showed that patients with diabetic retinopathy also had a more impaired DFRI and stress GLS. Multivariable analysis showed that the presence of diabetic retinopathy was independently associated with a higher resting E/E’, diastolic dysfunction grade, an impaired resting GLS, a low DFRI and impaired stress GLS. CONCLUSION: Patient with T2DM and retinopathy had impaired (i) resting myocardial function (diastolic function and GLS) and (ii) stress myocardial function (DFRI and ΔGLS) compared to those without retinopathy. Such data thus suggested that microvascular dysfunction contributed to both resting and stress myocardial dysfunction in patients with T2DM.
DescriptionPoster
Persistent Identifierhttp://hdl.handle.net/10722/230565
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorZhen, Z-
dc.contributor.authorChen, Y-
dc.contributor.authorWong, K-
dc.contributor.authorWong, DSH-
dc.contributor.authorLam, KSL-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2016-08-23T14:17:47Z-
dc.date.available2016-08-23T14:17:47Z-
dc.date.issued2015-
dc.identifier.citationThe 20th Medical Research Conference (MRC 2015), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 17 January 2015. In Hong Kong Medical Journal, 2015, v. 21 suppl. 1, p. 61, abstract no. 103-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/230565-
dc.descriptionPoster-
dc.description.abstractBACKGROUND: Type 2 diabetes mellitus (T2DM) complicated by retinopathy is associated with impaired left ventricular (LV) structure and resting myocardial dysfunction. The myocardial response to stress has not been compared in patients with and without diabetic retinopathy. METHODS: A total of 134 parents with T2DM without any history of cardiovascular disease were recruited. All patients underwent detailed retinal photography to screen for diabetic retinopathy, resting and exercise echocardiography. Resting echocardiography was analysed by (1) conventional echocardiographic parameters and (2) speckle tracking derived global longitudinal strain (GLS). Exercise echocardiography parameters included diastolic function reserve index (DFRI) and stress GLS. RESULTS: A total of 43 (23%) patients had retinopathy. For resting echocardiography, both LV dimension and LV ejection fraction were similar between patients with and without diabetic retinopathy. However, patients with retinopathy had a significantly impaired GLS, higher prevalence of diastolic dysfunction, a higher E/E’ ratio (LV filling pressure) compared with patients without retinopathy. Stress echocardiography also showed that patients with diabetic retinopathy also had a more impaired DFRI and stress GLS. Multivariable analysis showed that the presence of diabetic retinopathy was independently associated with a higher resting E/E’, diastolic dysfunction grade, an impaired resting GLS, a low DFRI and impaired stress GLS. CONCLUSION: Patient with T2DM and retinopathy had impaired (i) resting myocardial function (diastolic function and GLS) and (ii) stress myocardial function (DFRI and ΔGLS) compared to those without retinopathy. Such data thus suggested that microvascular dysfunction contributed to both resting and stress myocardial dysfunction in patients with T2DM.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleRelationship between diabetic retinopathy and subclinical myocardial dysfunction in patients with diabetic mellitus-
dc.typeConference_Paper-
dc.identifier.emailWong, DSH: shdwong@hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityWong, DSH=rp00516-
dc.identifier.authorityLam, KSL=rp00343-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.hkuros262997-
dc.identifier.volume21-
dc.identifier.issuesuppl. 1-
dc.identifier.spage61, abstract no. 103-
dc.identifier.epage61, abstract no. 103-
dc.publisher.placeHong Kong-

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