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Article: Separation and quantification of lactate and lipid at 1.3 ppm by diffusion-weighted magnetic resonance spectroscopy

TitleSeparation and quantification of lactate and lipid at 1.3 ppm by diffusion-weighted magnetic resonance spectroscopy
Authors
Keywordsmagnetic resonance spectroscopy
spectral overlapping
molecular size
lipid
lactate
diffusion weighting
C6 glioma
Issue Date2017
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance in Medicine, 2017, v. 77 n. 2, p. 480-489 How to Cite?
Abstract© 2016 International Society for Magnetic Resonance in Medicine Purpose: To separate the spectrally overlapped lactate and lipid signals at 1.3 ppm using diffusion-weighted magnetic resonance spectroscopy (DW-MRS) based on their large diffusivity difference. Methods: DW-MRS was applied to the gel phantoms containing lactate and lipid droplets, and to the rat brain tumors. Lactate and lipid signals and their apparent diffusion coefficients were computed from the diffusion-weighted proton spectra. Biexponential fitting and direct spectral subtraction approaches were employed and compared. Results: DW-MRS could effectively separate lactate and lipid signals both in phantoms and rat brain C6 glioma by biexponential fitting. In phantoms, lactate and lipid signals highly correlated with the known lactate concentration and lipid volume fractions. In C6 glioma, both lactate and lipid signals were detected, and the lipid signal was an order of magnitude higher than lactate signal. The spectral subtraction approach using three diffusion weightings also allowed the separation of lactate and lipid signals, yielding results comparable to those by the biexponential fitting approach. Conclusion: DW-MRS presents a new approach to separate and quantify spectrally overlapped molecules and/or macromolecules, such as lactate and lipid, by using the diffusivity difference associated with their different sizes or mobility within tissue microstructure. Magn Reson Med 77:480–489, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/229494
ISSN
2017 Impact Factor: 4.082
2015 SCImago Journal Rankings: 2.197
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, AM-
dc.contributor.authorLeung, GKK-
dc.contributor.authorKiang, MY-
dc.contributor.authorChan, D-
dc.contributor.authorCao, P-
dc.contributor.authorWu, EX-
dc.date.accessioned2016-08-23T14:11:29Z-
dc.date.available2016-08-23T14:11:29Z-
dc.date.issued2017-
dc.identifier.citationMagnetic Resonance in Medicine, 2017, v. 77 n. 2, p. 480-489-
dc.identifier.issn0740-3194-
dc.identifier.urihttp://hdl.handle.net/10722/229494-
dc.description.abstract© 2016 International Society for Magnetic Resonance in Medicine Purpose: To separate the spectrally overlapped lactate and lipid signals at 1.3 ppm using diffusion-weighted magnetic resonance spectroscopy (DW-MRS) based on their large diffusivity difference. Methods: DW-MRS was applied to the gel phantoms containing lactate and lipid droplets, and to the rat brain tumors. Lactate and lipid signals and their apparent diffusion coefficients were computed from the diffusion-weighted proton spectra. Biexponential fitting and direct spectral subtraction approaches were employed and compared. Results: DW-MRS could effectively separate lactate and lipid signals both in phantoms and rat brain C6 glioma by biexponential fitting. In phantoms, lactate and lipid signals highly correlated with the known lactate concentration and lipid volume fractions. In C6 glioma, both lactate and lipid signals were detected, and the lipid signal was an order of magnitude higher than lactate signal. The spectral subtraction approach using three diffusion weightings also allowed the separation of lactate and lipid signals, yielding results comparable to those by the biexponential fitting approach. Conclusion: DW-MRS presents a new approach to separate and quantify spectrally overlapped molecules and/or macromolecules, such as lactate and lipid, by using the diffusivity difference associated with their different sizes or mobility within tissue microstructure. Magn Reson Med 77:480–489, 2017. © 2016 International Society for Magnetic Resonance in Medicine.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/-
dc.relation.ispartofMagnetic Resonance in Medicine-
dc.subjectmagnetic resonance spectroscopy-
dc.subjectspectral overlapping-
dc.subjectmolecular size-
dc.subjectlipid-
dc.subjectlactate-
dc.subjectdiffusion weighting-
dc.subjectC6 glioma-
dc.titleSeparation and quantification of lactate and lipid at 1.3 ppm by diffusion-weighted magnetic resonance spectroscopy-
dc.typeArticle-
dc.identifier.emailLeung, GKK: gkkleung@hku.hk-
dc.identifier.emailChan, D: chand@hku.hk-
dc.identifier.emailCao, P: caopeng1@hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityLeung, GKK=rp00522-
dc.identifier.authorityChan, D=rp00540-
dc.identifier.authorityCao, P=rp02474-
dc.identifier.authorityWu, EX=rp00193-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mrm.26144-
dc.identifier.scopuseid_2-s2.0-84957812657-
dc.identifier.hkuros260551-
dc.identifier.volume77-
dc.identifier.issue2-
dc.identifier.spage480-
dc.identifier.epage489-
dc.identifier.isiWOS:000394544700004-
dc.publisher.placeUnited States-

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