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- Publisher Website: 10.1371/journal.ppat.1005367
- Scopus: eid_2-s2.0-84956846133
- PMID: 26735852
- WOS: WOS:000369374500023
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Article: IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection
Title | IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection |
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Authors | |
Issue Date | 2016 |
Publisher | Public Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374 |
Citation | PLoS Pathogens, 2016, v. 12 n. 1, article no. e1005367 How to Cite? |
Abstract | B-1 cells play a critical role in early protection during influenza infections by producing natural IgM antibodies. However, the underlying mechanisms involved in regulating this process are largely unknown. Here we found that during influenza infection pleural cavity B-1a cells rapidly infiltrated lungs, where they underwent plasmacytic differentiation with enhanced IgM production. This process was promoted by IL-17A signaling via induction of Blimp-1 expression and NF-kB activation in B-1a cells. Deficiency of IL-17A led to severely impaired B-1a-derived antibody production in the respiratory tract, resulting in a deficiency in viral clearance. Transfer of B-1a-derived natural antibodies rescued Il17a(-/-) mice from otherwise lethal infections. Together, we identify a critical function of IL-17A in promoting the plasmacytic differentiation of B-1a cells. Our findings provide new insights into the mechanisms underlying the regulation of pulmonary B-1a cell response against influenza infection. |
Persistent Identifier | http://hdl.handle.net/10722/227861 |
ISSN | 2023 Impact Factor: 5.5 2023 SCImago Journal Rankings: 2.223 |
ISI Accession Number ID | |
Grants |
DC Field | Value | Language |
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dc.contributor.author | Wang, X | - |
dc.contributor.author | Ma, K | - |
dc.contributor.author | Chen, M | - |
dc.contributor.author | Ko, KH | - |
dc.contributor.author | Zheng, B | - |
dc.contributor.author | Lu, L | - |
dc.date.accessioned | 2016-07-21T02:29:13Z | - |
dc.date.available | 2016-07-21T02:29:13Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | PLoS Pathogens, 2016, v. 12 n. 1, article no. e1005367 | - |
dc.identifier.issn | 1553-7366 | - |
dc.identifier.uri | http://hdl.handle.net/10722/227861 | - |
dc.description.abstract | B-1 cells play a critical role in early protection during influenza infections by producing natural IgM antibodies. However, the underlying mechanisms involved in regulating this process are largely unknown. Here we found that during influenza infection pleural cavity B-1a cells rapidly infiltrated lungs, where they underwent plasmacytic differentiation with enhanced IgM production. This process was promoted by IL-17A signaling via induction of Blimp-1 expression and NF-kB activation in B-1a cells. Deficiency of IL-17A led to severely impaired B-1a-derived antibody production in the respiratory tract, resulting in a deficiency in viral clearance. Transfer of B-1a-derived natural antibodies rescued Il17a(-/-) mice from otherwise lethal infections. Together, we identify a critical function of IL-17A in promoting the plasmacytic differentiation of B-1a cells. Our findings provide new insights into the mechanisms underlying the regulation of pulmonary B-1a cell response against influenza infection. | - |
dc.language | eng | - |
dc.publisher | Public Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374 | - |
dc.relation.ispartof | PLoS Pathogens | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection | - |
dc.type | Article | - |
dc.identifier.email | Zheng, B: bzheng@hkucc.hku.hk | - |
dc.identifier.email | Lu, L: liweilu@hkucc.hku.hk | - |
dc.identifier.authority | Zheng, B=rp00353 | - |
dc.identifier.authority | Lu, L=rp00477 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1371/journal.ppat.1005367 | - |
dc.identifier.pmid | 26735852 | - |
dc.identifier.scopus | eid_2-s2.0-84956846133 | - |
dc.identifier.hkuros | 264116 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. e1005367 | - |
dc.identifier.epage | article no. e1005367 | - |
dc.identifier.isi | WOS:000369374500023 | - |
dc.publisher.place | United States | - |
dc.identifier.f1000 | 726058177 | - |
dc.relation.project | B-1 cell response and its regulation during influenza virus infection | - |
dc.identifier.issnl | 1553-7366 | - |