File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: Autoimmune encephalitis in Hong Kong Chinese patients: experience of a regional hospital

TitleAutoimmune encephalitis in Hong Kong Chinese patients: experience of a regional hospital
Authors
Issue Date2016
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
The 21st Medical Research Conference, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 January 2016. In Hong Kong Medical Journal, 2016, v. 22 suppl. 1, p. 10, abstract no. 2 How to Cite?
AbstractINTRODUCTION: Autoimmune encephalitis includes a heterogeneous group of non-infectious neuroinflammation of the brain characterised by detection of autoantibodies targeting a wide variety of neuronal and synaptic antigens in serum and/or cerebrospinal fluid (CSF) of patients. METHODS: Records of patients with a diagnostic code of autoimmune encephalitis confirmed with detection of specific neuronal, glial, or synaptic autoantibodies cared in Queen Mary Hospital from January 2001 to October 2015 were studied retrospectively. RESULTS: A total of 11 patients had symptomatic autoimmune encephalitis confirmed with detection of specific autoantibodies. Eight (72.7%) had neuromyelitis optica spectrum disorders seropositive for aquaporin-4 autoantibodies and had encephalitis involving various brain regions: hypothalamus (2), periaqueductal grey matter (3), periventricular region around fourth ventricle (3), ventral midbrain (3), dorsal pons and cerebellar peduncles (4), medulla commonly in continuity with high cervical myelitis (6) and periventricular white matter in cerebral hemispheres (2) and corpus callosum (1). Two patients had voltage-gated potassium channel complex antibodies detected in sera—one presented with confusion, memory loss, and disorientation with typical magnetic resonance imaging (MRI) brain findings of limbic encephalitis; the other presented with marked weight loss, insomnia, haemodynamic instability, limb weakness, and fasciculation suggestive of central, autonomic, and peripheral hyperexcitability. A single young woman presented with confusion, disorientation, followed by status epilepticus and involuntary facial dyskinesia with normal MRI brain. She had anti-NMDAR antibodies detected in her CSF but not serum, confirming the diagnosis of anti-NMDAR encephalitis. She had no ovarian teratoma or other tumour found. She responded well to pulse steroid and intravenous immunoglobulin during acute phase, and had no relapse for a year while on mycophenolate mofetil. CONCLUSION: Autoimmune encephalitis is a potentially severe but treatable neurological disorder. Detection of specific neuronal, glial, or synaptic autoantibodies greatly facilitates early diagnosis and prompt treatments.
Persistent Identifierhttp://hdl.handle.net/10722/227548
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChan, KH-
dc.contributor.authorTeo, KC-
dc.contributor.authorLau, KK-
dc.contributor.authorLeung, WI-
dc.contributor.authorHo, SL-
dc.contributor.authorCheung, RTF-
dc.contributor.authorChang, SKR-
dc.contributor.authorPang, SYY-
dc.contributor.authorLee, JCY-
dc.contributor.authorNg, CL-
dc.date.accessioned2016-07-18T09:11:22Z-
dc.date.available2016-07-18T09:11:22Z-
dc.date.issued2016-
dc.identifier.citationThe 21st Medical Research Conference, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 January 2016. In Hong Kong Medical Journal, 2016, v. 22 suppl. 1, p. 10, abstract no. 2-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/227548-
dc.description.abstractINTRODUCTION: Autoimmune encephalitis includes a heterogeneous group of non-infectious neuroinflammation of the brain characterised by detection of autoantibodies targeting a wide variety of neuronal and synaptic antigens in serum and/or cerebrospinal fluid (CSF) of patients. METHODS: Records of patients with a diagnostic code of autoimmune encephalitis confirmed with detection of specific neuronal, glial, or synaptic autoantibodies cared in Queen Mary Hospital from January 2001 to October 2015 were studied retrospectively. RESULTS: A total of 11 patients had symptomatic autoimmune encephalitis confirmed with detection of specific autoantibodies. Eight (72.7%) had neuromyelitis optica spectrum disorders seropositive for aquaporin-4 autoantibodies and had encephalitis involving various brain regions: hypothalamus (2), periaqueductal grey matter (3), periventricular region around fourth ventricle (3), ventral midbrain (3), dorsal pons and cerebellar peduncles (4), medulla commonly in continuity with high cervical myelitis (6) and periventricular white matter in cerebral hemispheres (2) and corpus callosum (1). Two patients had voltage-gated potassium channel complex antibodies detected in sera—one presented with confusion, memory loss, and disorientation with typical magnetic resonance imaging (MRI) brain findings of limbic encephalitis; the other presented with marked weight loss, insomnia, haemodynamic instability, limb weakness, and fasciculation suggestive of central, autonomic, and peripheral hyperexcitability. A single young woman presented with confusion, disorientation, followed by status epilepticus and involuntary facial dyskinesia with normal MRI brain. She had anti-NMDAR antibodies detected in her CSF but not serum, confirming the diagnosis of anti-NMDAR encephalitis. She had no ovarian teratoma or other tumour found. She responded well to pulse steroid and intravenous immunoglobulin during acute phase, and had no relapse for a year while on mycophenolate mofetil. CONCLUSION: Autoimmune encephalitis is a potentially severe but treatable neurological disorder. Detection of specific neuronal, glial, or synaptic autoantibodies greatly facilitates early diagnosis and prompt treatments.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleAutoimmune encephalitis in Hong Kong Chinese patients: experience of a regional hospital-
dc.typeConference_Paper-
dc.identifier.emailChan, KH: koonho@hku.hk-
dc.identifier.emailLau, KK: gkklau@hku.hk-
dc.identifier.emailHo, SL: slho@hku.hk-
dc.identifier.emailCheung, RTF: rtcheung@hkucc.hku.hk-
dc.identifier.emailChang, SKR: skrchang@hku.hk-
dc.identifier.emailPang, SYY: syypang@hku.hk-
dc.identifier.emailNg, CL: royclng@hku.hk-
dc.identifier.authorityChan, KH=rp00537-
dc.identifier.authorityLau, KK=rp01499-
dc.identifier.authorityHo, SL=rp00240-
dc.identifier.authorityCheung, RTF=rp00434-
dc.identifier.hkuros258971-
dc.identifier.volume22-
dc.identifier.issuesuppl. 1-
dc.identifier.spage10, abstract no. 2-
dc.identifier.epage10, abstract no. 2-
dc.publisher.placeHong Kong-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats