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Article: Targeting AMPK signaling in combating ovarian cancers: opportunities and challenges

TitleTargeting AMPK signaling in combating ovarian cancers: opportunities and challenges
Authors
Issue Date2016
PublisherOxford University Press. The Journal's web site is located at http://abbs.oxfordjournals.org/
Citation
Acta Biochimica et Biophysica Sinica, 2016, v. 48 n. 4, p. 301-317 How to Cite?
AbstractThe development and strategic application of effective anticancer therapies have turned out to be one of the most critical approaches of managing human cancers. Nevertheless, drug resistance is the major obstacle for clinical management of these diseases especially ovarian cancer. In the past years, substantial studies have been carried out with the aim of exploring alternative therapeutic approaches to enhance efficacy of current chemotherapeutic regimes and reduce the side effects caused in order to produce significant advantages in overall survival and to improve patients' quality of life. Targeting cancer cell metabolism by the application of AMP-activated protein kinase (AMPK)-activating agents is believed to be one of the most plausible attempts. AMPK activators such as 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside, A23187, metformin, and bitter melon extract not only prevent cancer progression and metastasis but can also be applied as a supplement to enhance the efficacy of cisplatin-based chemotherapy in human cancers such as ovarian cancer. However, because of the undesirable outcomes along with the frequent toxic side effects of most pharmaceutical AMPK activators that have been utilized in clinical trials, attentions of current studies have been aimed at the identification of replaceable reagents from nutraceuticals or traditional medicines. However, the underlying molecular mechanisms of many nutraceuticals in anticancer still remain obscure. Therefore, better understanding of the functional characterization and regulatory mechanism of natural AMPK activators would help pharmaceutical development in opening an area to intervene ovarian cancer and other human cancers.
Persistent Identifierhttp://hdl.handle.net/10722/223262
ISSN
2015 Impact Factor: 2.124
2015 SCImago Journal Rankings: 0.881

 

DC FieldValueLanguage
dc.contributor.authorYung, MMH-
dc.contributor.authorNgan, HYS-
dc.contributor.authorChan, DW-
dc.date.accessioned2016-02-23T01:56:20Z-
dc.date.available2016-02-23T01:56:20Z-
dc.date.issued2016-
dc.identifier.citationActa Biochimica et Biophysica Sinica, 2016, v. 48 n. 4, p. 301-317-
dc.identifier.issn1672-9145-
dc.identifier.urihttp://hdl.handle.net/10722/223262-
dc.description.abstractThe development and strategic application of effective anticancer therapies have turned out to be one of the most critical approaches of managing human cancers. Nevertheless, drug resistance is the major obstacle for clinical management of these diseases especially ovarian cancer. In the past years, substantial studies have been carried out with the aim of exploring alternative therapeutic approaches to enhance efficacy of current chemotherapeutic regimes and reduce the side effects caused in order to produce significant advantages in overall survival and to improve patients' quality of life. Targeting cancer cell metabolism by the application of AMP-activated protein kinase (AMPK)-activating agents is believed to be one of the most plausible attempts. AMPK activators such as 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside, A23187, metformin, and bitter melon extract not only prevent cancer progression and metastasis but can also be applied as a supplement to enhance the efficacy of cisplatin-based chemotherapy in human cancers such as ovarian cancer. However, because of the undesirable outcomes along with the frequent toxic side effects of most pharmaceutical AMPK activators that have been utilized in clinical trials, attentions of current studies have been aimed at the identification of replaceable reagents from nutraceuticals or traditional medicines. However, the underlying molecular mechanisms of many nutraceuticals in anticancer still remain obscure. Therefore, better understanding of the functional characterization and regulatory mechanism of natural AMPK activators would help pharmaceutical development in opening an area to intervene ovarian cancer and other human cancers.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://abbs.oxfordjournals.org/-
dc.relation.ispartofActa Biochimica et Biophysica Sinica-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Acta Biochimica et Biophysica Sinica following peer review. The definitive publisher-authenticated version Acta Biochimica et Biophysica Sinica, 2016, v. 48 n. 4, p. 301-317 is available online at: https://academic.oup.com/abbs/issue/48/4-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleTargeting AMPK signaling in combating ovarian cancers: opportunities and challenges-
dc.typeArticle-
dc.identifier.emailYung, MMH: mhyung@hku.hk-
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hk-
dc.identifier.emailChan, DW: dwchan@hku.hk-
dc.identifier.authorityNgan, HYS=rp00346-
dc.identifier.authorityChan, DW=rp00543-
dc.description.naturepostprint-
dc.identifier.doi10.1093/abbs/gmv128-
dc.identifier.pmid26764240-
dc.identifier.hkuros256901-
dc.identifier.volume48-
dc.identifier.issue4-
dc.identifier.spage301-
dc.identifier.epage317-
dc.publisher.placeUnited States-

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