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- Scopus: eid_2-s2.0-0036773437
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Article: A Group-Comparative, Randomized, Double-Blind Comparison of the Efficacy and Efficiency of Two Fixed Daily Dose Regimens (100- and 200-IU) of Recombinant Follicle Stimulating Hormone (rFSH, Puregon®) in Asian Women Undergoing Ovarian Stimulation for IVF/ICSI
Title | A Group-Comparative, Randomized, Double-Blind Comparison of the Efficacy and Efficiency of Two Fixed Daily Dose Regimens (100- and 200-IU) of Recombinant Follicle Stimulating Hormone (rFSH, Puregon®) in Asian Women Undergoing Ovarian Stimulation for IVF/ICSI |
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Authors | |
Keywords | Dosing ICSI IVF Puregon® Recombinant FSH |
Issue Date | 2002 |
Publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1058-0468 |
Citation | Journal of Assisted Reproduction and Genetics, 2002, v. 19 n. 10, p. 470-476 How to Cite? |
Abstract | Purpose : To compare the efficacy, efficacy and safety of a fixed daily dose of recombinant FSH (Puregon®) of a 100- and 200-IU regimen in Asian women undergoing ovarian stimulation for IVF/ICSI.
Methods : This was a prospective, randomized, double-blind, multicenter (n = 9) study. Prior to the start of rFSH, all women were pretreated with a gonadotropin releasing hormone agonist (GnRH-a) for pituitary downregulation.
Results : A total of 330 women were treated with rFSH: 163 subjects with 100 IU and 167 subjects with . In the 200 IU treatment group, significantly more oocytes were retrieved compared to the 100 IU group (9.6 vs. 5.0 oocytes, p < 0.001). The total dose rFSH needed to develop at least three follicles with a diameter of ≥17 mm was significantly lower in the 100 IU treatment group (1194 vs. 2034 IU, p < 0.001). Although more cycle cancellations were seen in the 100 IU group (24 vs. 13%), the ongoing pregnancy rate per started cycle was comparable between both groups (16.6% in the 100 IU group vs. 15.0% in the 200 IU group).
Conclusions : The use of a 100 IU fixed dose is less effective in terms of the number of oocytes retrieved and the higher cancellation rate, but more efficient as indicated by a lower total recombinant FSH dose needed. |
Persistent Identifier | http://hdl.handle.net/10722/222190 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.004 |
PubMed Central ID |
DC Field | Value | Language |
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dc.contributor.author | Ng, EHY | - |
dc.contributor.author | Hoomans, EHM | - |
dc.contributor.author | Mulder, BB | - |
dc.date.accessioned | 2015-12-30T06:48:52Z | - |
dc.date.available | 2015-12-30T06:48:52Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Journal of Assisted Reproduction and Genetics, 2002, v. 19 n. 10, p. 470-476 | - |
dc.identifier.issn | 1058-0468 | - |
dc.identifier.uri | http://hdl.handle.net/10722/222190 | - |
dc.description.abstract | Purpose : To compare the efficacy, efficacy and safety of a fixed daily dose of recombinant FSH (Puregon®) of a 100- and 200-IU regimen in Asian women undergoing ovarian stimulation for IVF/ICSI. Methods : This was a prospective, randomized, double-blind, multicenter (n = 9) study. Prior to the start of rFSH, all women were pretreated with a gonadotropin releasing hormone agonist (GnRH-a) for pituitary downregulation. Results : A total of 330 women were treated with rFSH: 163 subjects with 100 IU and 167 subjects with . In the 200 IU treatment group, significantly more oocytes were retrieved compared to the 100 IU group (9.6 vs. 5.0 oocytes, p < 0.001). The total dose rFSH needed to develop at least three follicles with a diameter of ≥17 mm was significantly lower in the 100 IU treatment group (1194 vs. 2034 IU, p < 0.001). Although more cycle cancellations were seen in the 100 IU group (24 vs. 13%), the ongoing pregnancy rate per started cycle was comparable between both groups (16.6% in the 100 IU group vs. 15.0% in the 200 IU group). Conclusions : The use of a 100 IU fixed dose is less effective in terms of the number of oocytes retrieved and the higher cancellation rate, but more efficient as indicated by a lower total recombinant FSH dose needed. | - |
dc.language | eng | - |
dc.publisher | Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1058-0468 | - |
dc.relation.ispartof | Journal of Assisted Reproduction and Genetics | - |
dc.rights | The final publication is available at Springer via http://dx.doi.org/10.1023/A:1020358419073 | - |
dc.subject | Dosing | - |
dc.subject | ICSI | - |
dc.subject | IVF | - |
dc.subject | Puregon® | - |
dc.subject | Recombinant FSH | - |
dc.subject.mesh | Fertility Agents, Female - therapeutic use | - |
dc.subject.mesh | Fertilization in Vitro - methods | - |
dc.subject.mesh | Follicle Stimulating Hormone - administration & dosage - adverse effects - therapeutic use | - |
dc.subject.mesh | Ovulation - drug effects - physiology | - |
dc.subject.mesh | Recombinant Proteins - administration & dosage - adverse effects - therapeutic use | - |
dc.title | A Group-Comparative, Randomized, Double-Blind Comparison of the Efficacy and Efficiency of Two Fixed Daily Dose Regimens (100- and 200-IU) of Recombinant Follicle Stimulating Hormone (rFSH, Puregon®) in Asian Women Undergoing Ovarian Stimulation for IVF/ICSI | - |
dc.type | Article | - |
dc.identifier.email | Ng, EHY: nghye@hkucc.hku.hk | - |
dc.identifier.authority | Ng, EHY=rp00426 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1023/A:1020358419073 | - |
dc.identifier.pmid | 12416651 | - |
dc.identifier.pmcid | PMC3455678 | - |
dc.identifier.scopus | eid_2-s2.0-0036773437 | - |
dc.identifier.hkuros | 78440 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 470 | - |
dc.identifier.epage | 476 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1058-0468 | - |