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Conference Paper: [Zn(phen)(O,N,O)(H2O)] and [Zn(phen)(O,N)(H2O)] with O,N,O is 2,6-dipicolinate and N,O is L-threoninate: Synthesis, characterization, and biomedical properties

Title[Zn(phen)(O,N,O)(H2O)] and [Zn(phen)(O,N)(H2O)] with O,N,O is 2,6-dipicolinate and N,O is L-threoninate: Synthesis, characterization, and biomedical properties
Authors
KeywordsNasopharyngeal carcinoma
Ternary zinc(II)-1, 10-phenanthroline complex
Topoisomerase I
Dipicolinic acid
L-Threonine
Issue Date2012
Citation
Journal of Biological Inorganic Chemistry, 2012, v. 17, n. 7, p. 1093-1105 How to Cite?
AbstractTwo ternary Zn(II) complexes, with 1,10-phenanthroline (phen) as the main ligand and a carboxylatecontaining ligand [dipicolinate (dipico) or L-threoninate (L-Thr)] as the subsidiary ligand, were prepared and characterized by elemental analysis, Fourier transform IR, UV, and fluorescence spectroscopy, X-ray diffraction, molar conductivity, and electrospray ionization mass spectrometry. X-ray structure analysis shows that both [Zn(phen)(dipico)(H 2O)]·H2O (1) and [Zn(phen)(L-Thr)(H 2O)Cl] ·2H2O (2) have octahedral geometry about the Zn(II) atom. Both complexes can inhibit topoisomerase I, and have better anticancer activity than cisplatin against nasopharyngeal cancer cell lines, HK1 and HONE-1, with concentrations causing 50 % inhibition of cell proliferation (IC50) in the low micromolar range. Complex 2 has the highest therapeutic index for HK1. Both Zn(II) complexes can induce cell death by apoptosis. Changing the subsidiary ligand in the Zn(II) complexes affects the UV-fluorescence spectral properties of the coordinated phen ligand, the binding affinity for some DNA sequences, nucleobase sequenceselective binding, the phase at which cell cycle progression was arrested for treated cancer cells, and their therapeutic index. © SBIC 2012.
Persistent Identifierhttp://hdl.handle.net/10722/219679
ISSN
2015 Impact Factor: 2.495
2015 SCImago Journal Rankings: 0.882

 

DC FieldValueLanguage
dc.contributor.authorChin, Lee Fang-
dc.contributor.authorKong, Siew Ming-
dc.contributor.authorSeng, Hoi Ling-
dc.contributor.authorTiong, Yee Lian-
dc.contributor.authorNeo, Kian Eang-
dc.contributor.authorMaah, Mohd Jamil-
dc.contributor.authorKhoo, Alan Soo Beng-
dc.contributor.authorAhmad, Munirah-
dc.contributor.authorHor, Tzi Sum Andy-
dc.contributor.authorLee, Hong Boon-
dc.contributor.authorSan, Swee Lan-
dc.contributor.authorChye, Soi Moi-
dc.contributor.authorNg, Chew Hee-
dc.date.accessioned2015-09-23T02:57:42Z-
dc.date.available2015-09-23T02:57:42Z-
dc.date.issued2012-
dc.identifier.citationJournal of Biological Inorganic Chemistry, 2012, v. 17, n. 7, p. 1093-1105-
dc.identifier.issn0949-8257-
dc.identifier.urihttp://hdl.handle.net/10722/219679-
dc.description.abstractTwo ternary Zn(II) complexes, with 1,10-phenanthroline (phen) as the main ligand and a carboxylatecontaining ligand [dipicolinate (dipico) or L-threoninate (L-Thr)] as the subsidiary ligand, were prepared and characterized by elemental analysis, Fourier transform IR, UV, and fluorescence spectroscopy, X-ray diffraction, molar conductivity, and electrospray ionization mass spectrometry. X-ray structure analysis shows that both [Zn(phen)(dipico)(H 2O)]·H2O (1) and [Zn(phen)(L-Thr)(H 2O)Cl] ·2H2O (2) have octahedral geometry about the Zn(II) atom. Both complexes can inhibit topoisomerase I, and have better anticancer activity than cisplatin against nasopharyngeal cancer cell lines, HK1 and HONE-1, with concentrations causing 50 % inhibition of cell proliferation (IC50) in the low micromolar range. Complex 2 has the highest therapeutic index for HK1. Both Zn(II) complexes can induce cell death by apoptosis. Changing the subsidiary ligand in the Zn(II) complexes affects the UV-fluorescence spectral properties of the coordinated phen ligand, the binding affinity for some DNA sequences, nucleobase sequenceselective binding, the phase at which cell cycle progression was arrested for treated cancer cells, and their therapeutic index. © SBIC 2012.-
dc.languageeng-
dc.relation.ispartofJournal of Biological Inorganic Chemistry-
dc.subjectNasopharyngeal carcinoma-
dc.subjectTernary zinc(II)-1, 10-phenanthroline complex-
dc.subjectTopoisomerase I-
dc.subjectDipicolinic acid-
dc.subjectL-Threonine-
dc.title[Zn(phen)(O,N,O)(H2O)] and [Zn(phen)(O,N)(H2O)] with O,N,O is 2,6-dipicolinate and N,O is L-threoninate: Synthesis, characterization, and biomedical properties-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00775-012-0923-y-
dc.identifier.pmid22825726-
dc.identifier.scopuseid_2-s2.0-84868149361-
dc.identifier.volume17-
dc.identifier.issue7-
dc.identifier.spage1093-
dc.identifier.epage1105-
dc.identifier.eissn1432-1327-

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