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Conference Paper: Application of whole exome sequencing in metachronous lung cancers evaluation

TitleApplication of whole exome sequencing in metachronous lung cancers evaluation
Authors
Issue Date2015
Citation
The 2015 European Association for Cancer Research Conference Series (EACR 2015), Cambridge, UK., 28 June-1 July 2015. How to Cite?
AbstractMultiplicity and metachronous tumours are recurrent management problems. Morphological resemblance, in-situ carcinoma, cancer driver mutations, etc. have been used to distinguish intrapulmonary metastasis and metachronous primary lung cancers but these criteria are often insufficient. Next generation sequencing promises to advance personalized cancer management but finding a practicable approach remains a problem. We explored the utility of whole exome sequencing for cancer nature determination in a 74 year-old female non-smoker with 2 sequential lung cancers of unknown relation. Initially, she had an EGFR-L858R adenocarcinoma (Tumour-A) treated by excision and adjuvant gefitinib for metastatic pleural tumours. Two years later while ...
DescriptionConference Theme: Cancer Genomics
Poster Abstracts: no. 69
Persistent Identifierhttp://hdl.handle.net/10722/219325

 

DC FieldValueLanguage
dc.contributor.authorWong, MP-
dc.contributor.authorGao, X-
dc.contributor.authorKwan, TK-
dc.contributor.authorXu, H-
dc.contributor.authorTin, VPC-
dc.contributor.authorWang, JJ-
dc.contributor.authorXiao, Z-
dc.contributor.authorXu, F-
dc.date.accessioned2015-09-18T07:21:58Z-
dc.date.available2015-09-18T07:21:58Z-
dc.date.issued2015-
dc.identifier.citationThe 2015 European Association for Cancer Research Conference Series (EACR 2015), Cambridge, UK., 28 June-1 July 2015.-
dc.identifier.urihttp://hdl.handle.net/10722/219325-
dc.descriptionConference Theme: Cancer Genomics-
dc.descriptionPoster Abstracts: no. 69-
dc.description.abstractMultiplicity and metachronous tumours are recurrent management problems. Morphological resemblance, in-situ carcinoma, cancer driver mutations, etc. have been used to distinguish intrapulmonary metastasis and metachronous primary lung cancers but these criteria are often insufficient. Next generation sequencing promises to advance personalized cancer management but finding a practicable approach remains a problem. We explored the utility of whole exome sequencing for cancer nature determination in a 74 year-old female non-smoker with 2 sequential lung cancers of unknown relation. Initially, she had an EGFR-L858R adenocarcinoma (Tumour-A) treated by excision and adjuvant gefitinib for metastatic pleural tumours. Two years later while ...-
dc.languageeng-
dc.relation.ispartofEuropean Association for Cancer Research Conference, EACR 2015-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleApplication of whole exome sequencing in metachronous lung cancers evaluation-
dc.typeConference_Paper-
dc.identifier.emailWong, MP: mwpik@hku.hk-
dc.identifier.emailTin, VPC: pctin@hku.hk-
dc.identifier.emailWang, JJ: junwen@hku.hk-
dc.identifier.emailXu, F: feng717@hku.hk-
dc.identifier.authorityWong, MP=rp00348-
dc.identifier.authorityWang, JJ=rp00280-
dc.description.naturepostprint-
dc.identifier.hkuros253115-

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