File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Evaluation of moderate alcohol use with QT interval and heart rate using mendelian randomization analysis among older Southern Chinese men in the Guangzhou Biobank Cohort Study

TitleEvaluation of moderate alcohol use with QT interval and heart rate using mendelian randomization analysis among older Southern Chinese men in the Guangzhou Biobank Cohort Study
Authors
Keywordselectrocardiogram
Chinese
alcohol
Mendelian randomization
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/
Citation
American Journal of Epidemiology, 2015, v. 182 n. 4, p. 320-327 How to Cite?
Abstract© The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved.Western observational studies show that moderate alcohol use is associated with lower cardiovascular disease (CVD) risk, but these associations may be confounded by the healthier attributes of moderate users in these settings. Mendelian randomization analysis may help to ascertain the causal effect of moderate alcohol use on specific factors related to CVD and thereby clarify the role of alcohol. We used Mendelian randomization analysis with the aldehyde dehydrogenase 2 gene (ALDH2) as an instrumental variable to examine the association of alcohol units (10 g of ethanol) per day with heart rate-corrected QT interval and heart rate assessed from electrocardiogram among 4,588 older southern Chinese men in the Guangzhou Biobank Cohort Study (2003-2008). The F statistic was 77 for ALDH2 on alcohol use, suggesting little weak-instrument bias. Instrumental variable analysis showed that alcohol units were not associated with the corrected QT interval, with β = 1.04 (95% confidence interval: -0.61, 2.70) milliseconds, but they were associated with increased heart rate, with β = 0.98 (95% confidence interval: 0.04, 1.92) beat per minute. This study suggests that moderate alcohol use in men is not beneficial for heart function via QT interval or heart rate but could be detrimental. Future studies using specific cardiovascular outcomes may elucidate how alcohol affects different aspects of the cardiovascular system and, hence, the overall effects of alcohol on CVD can be estimated.
Persistent Identifierhttp://hdl.handle.net/10722/218495
ISSN
2015 Impact Factor: 5.036
2015 SCImago Journal Rankings: 3.047

 

DC FieldValueLanguage
dc.contributor.authorAu Yeung, SLR-
dc.contributor.authorJiang, C-
dc.contributor.authorLong, M-
dc.contributor.authorCheng, KK-
dc.contributor.authorLiu, B-
dc.contributor.authorZhang, W-
dc.contributor.authorLam, TH-
dc.contributor.authorLeung, GM-
dc.contributor.authorSchooling, CM-
dc.date.accessioned2015-09-18T06:40:28Z-
dc.date.available2015-09-18T06:40:28Z-
dc.date.issued2015-
dc.identifier.citationAmerican Journal of Epidemiology, 2015, v. 182 n. 4, p. 320-327-
dc.identifier.issn0002-9262-
dc.identifier.urihttp://hdl.handle.net/10722/218495-
dc.description.abstract© The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved.Western observational studies show that moderate alcohol use is associated with lower cardiovascular disease (CVD) risk, but these associations may be confounded by the healthier attributes of moderate users in these settings. Mendelian randomization analysis may help to ascertain the causal effect of moderate alcohol use on specific factors related to CVD and thereby clarify the role of alcohol. We used Mendelian randomization analysis with the aldehyde dehydrogenase 2 gene (ALDH2) as an instrumental variable to examine the association of alcohol units (10 g of ethanol) per day with heart rate-corrected QT interval and heart rate assessed from electrocardiogram among 4,588 older southern Chinese men in the Guangzhou Biobank Cohort Study (2003-2008). The F statistic was 77 for ALDH2 on alcohol use, suggesting little weak-instrument bias. Instrumental variable analysis showed that alcohol units were not associated with the corrected QT interval, with β = 1.04 (95% confidence interval: -0.61, 2.70) milliseconds, but they were associated with increased heart rate, with β = 0.98 (95% confidence interval: 0.04, 1.92) beat per minute. This study suggests that moderate alcohol use in men is not beneficial for heart function via QT interval or heart rate but could be detrimental. Future studies using specific cardiovascular outcomes may elucidate how alcohol affects different aspects of the cardiovascular system and, hence, the overall effects of alcohol on CVD can be estimated.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/-
dc.relation.ispartofAmerican Journal of Epidemiology-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in American Journal of Epidemiology following peer review. The definitive publisher-authenticated version American Journal of Epidemiology, 2015, v. 182 n. 4, p. 320-327 is available online at: http://aje.oxfordjournals.org/content/182/4/320-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectelectrocardiogram-
dc.subjectChinese-
dc.subjectalcohol-
dc.subjectMendelian randomization-
dc.titleEvaluation of moderate alcohol use with QT interval and heart rate using mendelian randomization analysis among older Southern Chinese men in the Guangzhou Biobank Cohort Study-
dc.typeArticle-
dc.identifier.emailAu Yeung, SLR: ayslryan@hku.hk-
dc.identifier.emailJiang, C: cqjiang@hkucc.hku.hk-
dc.identifier.emailCheng, KK: chengkk@hkucc.hku.hk-
dc.identifier.emailZhang, W: zhangws9@hku.hk-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hk-
dc.identifier.authorityLam, TH=rp00326-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authoritySchooling, CM=rp00504-
dc.description.naturepostprint-
dc.identifier.doi10.1093/aje/kwv069-
dc.identifier.pmid26153479-
dc.identifier.scopuseid_2-s2.0-84940195583-
dc.identifier.hkuros252409-
dc.identifier.volume182-
dc.identifier.issue4-
dc.identifier.spage320-
dc.identifier.epage327-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats