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Article: Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation

TitleSuppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation
Authors
Issue Date2015
PublisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org
Citation
Journal of General Virology, 2015, v. 96 n. 11, p. 3204-3211 How to Cite?
AbstractSevere fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen causing significant morbidity and mortality in Asia. NSs protein of SFTSV is known to perturb type I IFN induction and signalling, but the mechanism remains to be fully understood. Here, we showed the suppression of both type I and type III IFN signalling by SFTSV NSs protein is mediated through inhibition of STAT1 phosphorylation and activation. Infection with live SFTSV or expression of NSs potently suppressed IFN-stimulated genes but not NFκB activation. NSs was capable of counteracting the activity of IFN-α1, IFN-β, IFN-λ1 and IFN-λ2. Mechanistically, NSs associated with STAT1 and STAT2, mitigated IFN-β-induced phosphorylation of STAT1 at S727, and reduced the expression and activity of STAT1 protein in IFN-β-treated cells, resulting in the inhibition of STAT1 and STAT2 recruitment to IFN-stimulated promoters. Taken together, SFTSV NSs protein is an IFN antagonist that suppresses phosphorylation and activation of STAT1.
Persistent Identifierhttp://hdl.handle.net/10722/216602
ISSN
2015 Impact Factor: 3.192
2015 SCImago Journal Rankings: 1.741

 

DC FieldValueLanguage
dc.contributor.authorChaudhary, V-
dc.contributor.authorZhang, S-
dc.contributor.authorYuen, KS-
dc.contributor.authorLi, C-
dc.contributor.authorLui, PY-
dc.contributor.authorFung, SY-
dc.contributor.authorWang, PH-
dc.contributor.authorChan, CP-
dc.contributor.authorLi, D-
dc.contributor.authorKok, KH-
dc.contributor.authorLiang, M-
dc.contributor.authorJin, D-
dc.date.accessioned2015-09-18T05:33:27Z-
dc.date.available2015-09-18T05:33:27Z-
dc.date.issued2015-
dc.identifier.citationJournal of General Virology, 2015, v. 96 n. 11, p. 3204-3211-
dc.identifier.issn0022-1317-
dc.identifier.urihttp://hdl.handle.net/10722/216602-
dc.description.abstractSevere fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen causing significant morbidity and mortality in Asia. NSs protein of SFTSV is known to perturb type I IFN induction and signalling, but the mechanism remains to be fully understood. Here, we showed the suppression of both type I and type III IFN signalling by SFTSV NSs protein is mediated through inhibition of STAT1 phosphorylation and activation. Infection with live SFTSV or expression of NSs potently suppressed IFN-stimulated genes but not NFκB activation. NSs was capable of counteracting the activity of IFN-α1, IFN-β, IFN-λ1 and IFN-λ2. Mechanistically, NSs associated with STAT1 and STAT2, mitigated IFN-β-induced phosphorylation of STAT1 at S727, and reduced the expression and activity of STAT1 protein in IFN-β-treated cells, resulting in the inhibition of STAT1 and STAT2 recruitment to IFN-stimulated promoters. Taken together, SFTSV NSs protein is an IFN antagonist that suppresses phosphorylation and activation of STAT1.-
dc.languageeng-
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org-
dc.relation.ispartofJournal of General Virology-
dc.rightsJournal of General Virology. Copyright © Society for General Microbiology.-
dc.rightsThis is an author manuscript that has been accepted for publication in Journal of General Virology, copyright Society for General Microbiology, but has not been copy-edited, formatted or proofed. Cite this article as appearing in Journal of General Virology. This version of the manuscript may not be duplicated or reproduced, other than for personal use or within the rule of 'Fair Use of Copyrighted Materials' (section 17, Title 17, US Code), without permission from the copyright owner, Society for General Microbiology. The Society for General Microbiology disclaims any responsibility or liability for errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final copy-edited, published article, which is the version of record, can be found at http://vir.sgmjournals.org, and is freely available without a subscription.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleSuppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation-
dc.typeArticle-
dc.identifier.emailYuen, KS: samyuen@hku.hk-
dc.identifier.emailLui, PY: lpyin72@connect.hku.hk-
dc.identifier.emailChan, CP: chancp10@hku.hk-
dc.identifier.emailKok, KH: khkok@hku.hk-
dc.identifier.emailJin, D: dyjin@hku.hk-
dc.identifier.authorityChan, CP=rp02031-
dc.identifier.authorityKok, KH=rp01455-
dc.identifier.authorityJin, D=rp00452-
dc.description.naturepostprint-
dc.identifier.doi10.1099/jgv.0.000280-
dc.identifier.hkuros254032-
dc.identifier.volume96-
dc.identifier.issue11-
dc.identifier.spage3204-
dc.identifier.epage3211-
dc.publisher.placeUnited Kingdom-

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