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Conference Paper: Thymomatous myasthenia gravis in Hong Kong Chinese

TitleThymomatous myasthenia gravis in Hong Kong Chinese
Authors
Issue Date2015
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
The 20th Medical Research Conference, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 17 January 2015. In Hong Kong Medical Journal, 2015, v. 21 n. suppl. 1, p. 33, abstract no. 48 How to Cite?
AbstractINTRODUCTION: Myasthenia gravis (MG) is an important autoimmune disease causing generalised weakness and even mortality. It is associated with pathological abnormalities of the thymus gland in about 80% to 85% of patients. The reported frequencies of thymoma in MG patients is about 10% to 20% and thymomatous MG (T-MG) was in general believed to be more severe and associated with worse prognosis. We studied the frequency, clinical features, and long-term outcome of T-MG in our population. METHODS: Records of generalised MG (gMG) patients cared in Queen Mary Hospital (QMH) and followed up in QMH neurology clinic from 1997 to 2012 were reviewed. RESULTS: Overall, 123 gMG patients were studied and 45 (36.6%) of them had thymoma. Of these 45 patients, 42 (93.3%) T-MG had thymectomy compared to only 44% in non-thymomatous gMG (NT-MG) patients. There was no significant difference in the mean age of onset in T-MG (45.14 years) compared to NT-MG patients (45.04 years), but early onset disease (<40 years of age) was more common in NT-MG (odds ratio [OR]=2.41, P=0.03). Univariate analysis revealed that T-MG patients had higher frequencies of anti-AChR Ab seropositivity (100% vs 81.2%, P=0.002) and anti-striated muscle Ab seropositivity (70.4% vs 30.6%, P=0.002), and lower frequency of other autoimmune diseases (6.7% vs 25.3% P=0.014) than NT-MG, but were indifferent in sex, onset and worst clinical severity, presence of bulbar symptoms, history of MG crisis, co-morbidity status, and use of immunosuppressive therapies. There was no difference in long-term clinical outcome between T-MG and NTMG patients. In multivariate analysis, T-MG was found to be associated with higher frequency of anti-striated muscle Ab (OR=3.97, P=0.029) and lower frequency of other autoimmune diseases (OR=0.18, P=0.049). CONCLUSION: Frequency of thymoma in local Chinese MG patients appeared to be higher than MG patients in other regions of the world. Overall the clinical features appeared similar between T-MG and NT-MG patients. With prompt and proper treatment, the long-term prognosis is also similar between the two groups.
DescriptionPoster Presentation
Persistent Identifierhttp://hdl.handle.net/10722/214865
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLee, CYJ-
dc.contributor.authorPang, SYY-
dc.contributor.authorLau, GKK-
dc.contributor.authorChang, SKR-
dc.contributor.authorChang, C-
dc.contributor.authorTeo, KC-
dc.contributor.authorMak, W-
dc.contributor.authorCheung, RTF-
dc.contributor.authorHo, SL-
dc.contributor.authorChan, KH-
dc.date.accessioned2015-08-21T11:59:29Z-
dc.date.available2015-08-21T11:59:29Z-
dc.date.issued2015-
dc.identifier.citationThe 20th Medical Research Conference, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 17 January 2015. In Hong Kong Medical Journal, 2015, v. 21 n. suppl. 1, p. 33, abstract no. 48-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/214865-
dc.descriptionPoster Presentation-
dc.description.abstractINTRODUCTION: Myasthenia gravis (MG) is an important autoimmune disease causing generalised weakness and even mortality. It is associated with pathological abnormalities of the thymus gland in about 80% to 85% of patients. The reported frequencies of thymoma in MG patients is about 10% to 20% and thymomatous MG (T-MG) was in general believed to be more severe and associated with worse prognosis. We studied the frequency, clinical features, and long-term outcome of T-MG in our population. METHODS: Records of generalised MG (gMG) patients cared in Queen Mary Hospital (QMH) and followed up in QMH neurology clinic from 1997 to 2012 were reviewed. RESULTS: Overall, 123 gMG patients were studied and 45 (36.6%) of them had thymoma. Of these 45 patients, 42 (93.3%) T-MG had thymectomy compared to only 44% in non-thymomatous gMG (NT-MG) patients. There was no significant difference in the mean age of onset in T-MG (45.14 years) compared to NT-MG patients (45.04 years), but early onset disease (<40 years of age) was more common in NT-MG (odds ratio [OR]=2.41, P=0.03). Univariate analysis revealed that T-MG patients had higher frequencies of anti-AChR Ab seropositivity (100% vs 81.2%, P=0.002) and anti-striated muscle Ab seropositivity (70.4% vs 30.6%, P=0.002), and lower frequency of other autoimmune diseases (6.7% vs 25.3% P=0.014) than NT-MG, but were indifferent in sex, onset and worst clinical severity, presence of bulbar symptoms, history of MG crisis, co-morbidity status, and use of immunosuppressive therapies. There was no difference in long-term clinical outcome between T-MG and NTMG patients. In multivariate analysis, T-MG was found to be associated with higher frequency of anti-striated muscle Ab (OR=3.97, P=0.029) and lower frequency of other autoimmune diseases (OR=0.18, P=0.049). CONCLUSION: Frequency of thymoma in local Chinese MG patients appeared to be higher than MG patients in other regions of the world. Overall the clinical features appeared similar between T-MG and NT-MG patients. With prompt and proper treatment, the long-term prognosis is also similar between the two groups.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleThymomatous myasthenia gravis in Hong Kong Chinese-
dc.typeConference_Paper-
dc.identifier.emailPang, SYY: syypang@hku.hk-
dc.identifier.emailLau, GKK: gkklau@hku.hk-
dc.identifier.emailChang, SKR: skrchang@hku.hk-
dc.identifier.emailMak, W: wwwmak@hku.hk-
dc.identifier.emailCheung, RTF: rtcheung@hkucc.hku.hk-
dc.identifier.emailHo, SL: slho@hku.hk-
dc.identifier.emailChan, KH: koonho@hku.hk-
dc.identifier.authorityLau, GKK=rp01499-
dc.identifier.authorityCheung, RTF=rp00434-
dc.identifier.authorityHo, SL=rp00240-
dc.identifier.authorityChan, KH=rp00537-
dc.identifier.hkuros247974-
dc.identifier.hkuros258975-
dc.identifier.volume21-
dc.identifier.issuesuppl. 1-
dc.identifier.spage33, abstract no. 48-
dc.identifier.epage33, abstract no. 48-
dc.publisher.placeHong Kong-

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