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Article: Prognostic significance of minichromosome maintenance proteins in breast cancer

TitlePrognostic significance of minichromosome maintenance proteins in breast cancer
Authors
Issue Date2015
Citation
American Journal of Cancer Research, 2015, v. 5 n. 1, p. 52-71 How to Cite?
AbstractA role for the minichromosome maintenance (MCM) proteins in cancer initiation and progression is slowly emerging. Functioning as a complex to ensure a single chromosomal replication per cell cycle, the six family members have been implicated in several neoplastic disease states, including breast cancer. Our study aim to investigate the prognostic significance of these proteins in breast cancer. We studied the expression of MCMs in various datasets and the associations of the expression with clinicopathological parameters. When considered alone, high level MCM4 overexpression was only weakly associated with shorter survival in the combined breast cancer patient cohort (n = 1441, Hazard Ratio = 1.31; 95% Confidence Interval = 1.11-1.55; p = 0.001). On the other hand, when we studied all six components of the MCM complex, we found that overexpression of all MCMs was strongly associated with shorter survival in the same cohort (n = 1441, Hazard Ratio = 1.75; 95% Confidence Interval = 1.31-2.34; p < 0.001), suggesting these MCM proteins may cooperate to promote breast cancer progression. Indeed, their expressions were significantly correlated with each other in these cohorts. In addition, we found that increasing number of overexpressed MCMs was associated with negative ER status as well as treatment response. Together, our findings are reproducible in seven independent breast cancer cohorts, with 1441 patients, and suggest that MCM profiling could potentially be used to predict response to treatment and prognosis in breast cancer patients.
Persistent Identifierhttp://hdl.handle.net/10722/214738
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 3.756
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorKwok, HF-
dc.contributor.authorZhang, SD-
dc.contributor.authorMcCrudden, CM-
dc.contributor.authorYuen, HF-
dc.contributor.authorTing, KP-
dc.contributor.authorWen, Q-
dc.contributor.authorKhoo, US-
dc.contributor.authorChan, YK-
dc.date.accessioned2015-08-21T11:53:43Z-
dc.date.available2015-08-21T11:53:43Z-
dc.date.issued2015-
dc.identifier.citationAmerican Journal of Cancer Research, 2015, v. 5 n. 1, p. 52-71-
dc.identifier.issn2156-6976-
dc.identifier.urihttp://hdl.handle.net/10722/214738-
dc.description.abstractA role for the minichromosome maintenance (MCM) proteins in cancer initiation and progression is slowly emerging. Functioning as a complex to ensure a single chromosomal replication per cell cycle, the six family members have been implicated in several neoplastic disease states, including breast cancer. Our study aim to investigate the prognostic significance of these proteins in breast cancer. We studied the expression of MCMs in various datasets and the associations of the expression with clinicopathological parameters. When considered alone, high level MCM4 overexpression was only weakly associated with shorter survival in the combined breast cancer patient cohort (n = 1441, Hazard Ratio = 1.31; 95% Confidence Interval = 1.11-1.55; p = 0.001). On the other hand, when we studied all six components of the MCM complex, we found that overexpression of all MCMs was strongly associated with shorter survival in the same cohort (n = 1441, Hazard Ratio = 1.75; 95% Confidence Interval = 1.31-2.34; p < 0.001), suggesting these MCM proteins may cooperate to promote breast cancer progression. Indeed, their expressions were significantly correlated with each other in these cohorts. In addition, we found that increasing number of overexpressed MCMs was associated with negative ER status as well as treatment response. Together, our findings are reproducible in seven independent breast cancer cohorts, with 1441 patients, and suggest that MCM profiling could potentially be used to predict response to treatment and prognosis in breast cancer patients.-
dc.languageeng-
dc.relation.ispartofAmerican Journal of Cancer Research-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titlePrognostic significance of minichromosome maintenance proteins in breast cancer-
dc.typeArticle-
dc.identifier.emailKhoo, US: uskhoo@hku.hk-
dc.identifier.emailChan, YK: ykchanc@hku.hk-
dc.identifier.authorityKhoo, US=rp00362-
dc.identifier.authorityChan, YK=rp00453-
dc.description.naturepublished_or_final_version-
dc.identifier.pmid25628920-
dc.identifier.pmcidPMC4300722-
dc.identifier.hkuros249220-
dc.identifier.volume5-
dc.identifier.issue1-
dc.identifier.spage52-
dc.identifier.epage71-

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