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Article: MicroRNA-210 and endoplasmic reticulum chaperones in the regulation of chemoresistance in glioblastoma

TitleMicroRNA-210 and endoplasmic reticulum chaperones in the regulation of chemoresistance in glioblastoma
Authors
Issue Date2015
PublisherIvyspring International Publisher. The Journal's web site is located at http://www.jcancer.org/
Citation
Journal of Cancer, 2015, v. 6 n. 3, p. 227-232 How to Cite?
AbstractGlioblastoma multiforme (GBM) is the commonest primary brain tumour in adults characterized by relentless recurrence due to resistance towards the standard chemotherapeutic agent temozolomide (TMZ). Prolyl 4-hydroxylase, beta polypeptide (P4HB), an endoplasmic reticulum (ER) chaperone, is known to be upregulated in TMZ-resistant GBM cells. MicroRNAs (miRNAs) are non-protein-coding transcripts that may play important roles in GBM chemoresistance. We surmised that miRNA dysregulations may contribute to P4HB upregulation, hence chemoresistance.We found that miRNA-210 (miR-210) was P4HB-targeting and was highly downregulated in TMZ-resistant GBM cells. Forced overexpression of miR-210 led to P4HB downregulation and a reduction in TMZ-resistance. A reciprocal relationship between their expressions was also verified in clinical glioma specimens. Our study is the first to demonstrate a potential link between miR-210 and ER chaperone in determining chemosensitivity in GBM. The findings have important translational implications in suggesting new directions of future studies.
Persistent Identifierhttp://hdl.handle.net/10722/214596
ISSN
2015 Impact Factor: 3.609
2015 SCImago Journal Rankings: 1.445

 

DC FieldValueLanguage
dc.contributor.authorLee, D-
dc.contributor.authorSun, S-
dc.contributor.authorZhang, XQ-
dc.contributor.authorZhang, PD-
dc.contributor.authorHo, ASW-
dc.contributor.authorKiang, KMY-
dc.contributor.authorFung, CF-
dc.contributor.authorLui, WM-
dc.contributor.authorLeung, GKK-
dc.date.accessioned2015-08-21T11:40:08Z-
dc.date.available2015-08-21T11:40:08Z-
dc.date.issued2015-
dc.identifier.citationJournal of Cancer, 2015, v. 6 n. 3, p. 227-232-
dc.identifier.issn1837-9664-
dc.identifier.urihttp://hdl.handle.net/10722/214596-
dc.description.abstractGlioblastoma multiforme (GBM) is the commonest primary brain tumour in adults characterized by relentless recurrence due to resistance towards the standard chemotherapeutic agent temozolomide (TMZ). Prolyl 4-hydroxylase, beta polypeptide (P4HB), an endoplasmic reticulum (ER) chaperone, is known to be upregulated in TMZ-resistant GBM cells. MicroRNAs (miRNAs) are non-protein-coding transcripts that may play important roles in GBM chemoresistance. We surmised that miRNA dysregulations may contribute to P4HB upregulation, hence chemoresistance.We found that miRNA-210 (miR-210) was P4HB-targeting and was highly downregulated in TMZ-resistant GBM cells. Forced overexpression of miR-210 led to P4HB downregulation and a reduction in TMZ-resistance. A reciprocal relationship between their expressions was also verified in clinical glioma specimens. Our study is the first to demonstrate a potential link between miR-210 and ER chaperone in determining chemosensitivity in GBM. The findings have important translational implications in suggesting new directions of future studies.-
dc.languageeng-
dc.publisherIvyspring International Publisher. The Journal's web site is located at http://www.jcancer.org/-
dc.relation.ispartofJournal of Cancer-
dc.rightsJournal of Cancer. Copyright © Ivyspring International Publisher.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMicroRNA-210 and endoplasmic reticulum chaperones in the regulation of chemoresistance in glioblastoma-
dc.typeArticle-
dc.identifier.emailZhang, PD: pingder@hku.hk-
dc.identifier.emailLeung, GKK: gilberto@hkucc.hku.hk-
dc.identifier.authorityLeung, GKK=rp00522-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.7150/jca.10765-
dc.identifier.pmid25663939-
dc.identifier.hkuros246820-
dc.identifier.volume6-
dc.identifier.issue3-
dc.identifier.spage227-
dc.identifier.epage232-
dc.publisher.placeAustralia-

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