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Conference Paper: In Vivo tumor interstitial fluid pressure measurement using static micro force sensor and mechanical tumor model

TitleIn Vivo tumor interstitial fluid pressure measurement using static micro force sensor and mechanical tumor model
Authors
Issue Date2014
Citation
IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM, 2014, p. 587-592 How to Cite?
AbstractThe interstitial fluid pressure (IFP) plays a major role in tumor formation. Increased IFP may hinder the tran-scapillary transport of therapeutic agents as well as the large molecules, and may also lead to a poor prognosis for some cancer patients. IFP may therefore be an important biomarker. Serial noninvasive IFP measurement in vivo may facilitate drug development, if quantitative IFP data could be used for comparison. This paper proposes a novel technique employing a drift-compensated numerical Polyvinylidene Fluoride (PVDF) micro-force sensor and a load-deformation mechanical model of tumor to estimate the IFP. Experiments are carried out to verify the feasibility of the method and convincing data show its potential for in vivo tumor pressure measurement. © 2014 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/213427

 

DC FieldValueLanguage
dc.contributor.authorSun, Zhiyong-
dc.contributor.authorYang, Ruiguo-
dc.contributor.authorKovalenko, Pavlo-
dc.contributor.authorSong, Bo-
dc.contributor.authorChen, Liangliang-
dc.contributor.authorWalsh, Mary F.-
dc.contributor.authorHao, Lina-
dc.contributor.authorBasson, Marc D.-
dc.contributor.authorXi, Ning-
dc.date.accessioned2015-07-28T04:07:14Z-
dc.date.available2015-07-28T04:07:14Z-
dc.date.issued2014-
dc.identifier.citationIEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM, 2014, p. 587-592-
dc.identifier.urihttp://hdl.handle.net/10722/213427-
dc.description.abstractThe interstitial fluid pressure (IFP) plays a major role in tumor formation. Increased IFP may hinder the tran-scapillary transport of therapeutic agents as well as the large molecules, and may also lead to a poor prognosis for some cancer patients. IFP may therefore be an important biomarker. Serial noninvasive IFP measurement in vivo may facilitate drug development, if quantitative IFP data could be used for comparison. This paper proposes a novel technique employing a drift-compensated numerical Polyvinylidene Fluoride (PVDF) micro-force sensor and a load-deformation mechanical model of tumor to estimate the IFP. Experiments are carried out to verify the feasibility of the method and convincing data show its potential for in vivo tumor pressure measurement. © 2014 IEEE.-
dc.languageeng-
dc.relation.ispartofIEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM-
dc.titleIn Vivo tumor interstitial fluid pressure measurement using static micro force sensor and mechanical tumor model-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1109/AIM.2014.6878142-
dc.identifier.scopuseid_2-s2.0-84906669988-
dc.identifier.spage587-
dc.identifier.epage592-

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