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Conference Paper: Ultra-compliant thermal AFM probes for studying of cellular properties

TitleUltra-compliant thermal AFM probes for studying of cellular properties
Authors
Issue Date2010
Citation
2010 10th IEEE Conference on Nanotechnology, NANO 2010, 2010, p. 369-372 How to Cite?
AbstractAtomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids. ©2010 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/213156

 

DC FieldValueLanguage
dc.contributor.authorLai, King Wai Chiu-
dc.contributor.authorGaitas, Angelo-
dc.contributor.authorYang, Ruiguo-
dc.contributor.authorFung, Carmen Kar Man-
dc.contributor.authorXi, Ning-
dc.date.accessioned2015-07-28T04:06:19Z-
dc.date.available2015-07-28T04:06:19Z-
dc.date.issued2010-
dc.identifier.citation2010 10th IEEE Conference on Nanotechnology, NANO 2010, 2010, p. 369-372-
dc.identifier.urihttp://hdl.handle.net/10722/213156-
dc.description.abstractAtomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids. ©2010 IEEE.-
dc.languageeng-
dc.relation.ispartof2010 10th IEEE Conference on Nanotechnology, NANO 2010-
dc.titleUltra-compliant thermal AFM probes for studying of cellular properties-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1109/NANO.2010.5697767-
dc.identifier.scopuseid_2-s2.0-79951846724-
dc.identifier.spage369-
dc.identifier.epage372-

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