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Conference Paper: An experimental study on protein-protein interaction using atomic force microscopy

TitleAn experimental study on protein-protein interaction using atomic force microscopy
Authors
Issue Date2010
Citation
2010 10th IEEE Conference on Nanotechnology, NANO 2010, 2010, p. 983-986 How to Cite?
AbstractElucidating the underlying mechanism of the cellular physiological activities at the molecular level is currently an important research topic in life sciences. The invention of the atomic force microscopy (AFM) provided new methods for acquiring new cognition about cellular chemical processes. With the use of AFM, the specific recognition interaction between CD20 antigen and rituximab antibody on B lymphoma cells was explored under near-physiological conditions. The high quality AFM images of B lymphoma cells were acquired and the CD20-rituximab complex binding force was measured by AFM single-molecule force spectroscopy (SMFS). The experimental results provide new insights for understanding the CD20-rituximab specific interaction and lay the foundation for the further investigation of the mechanism of rituximab. ©2010 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/213154

 

DC FieldValueLanguage
dc.contributor.authorLi, Mi-
dc.contributor.authorLiu, Lianqing-
dc.contributor.authorXi, Ning-
dc.contributor.authorWang, Yuechao-
dc.contributor.authorDong, Zaili-
dc.contributor.authorLi, Guangyong-
dc.contributor.authorXiao, Xiubin-
dc.contributor.authorZhang, Weijing-
dc.date.accessioned2015-07-28T04:06:18Z-
dc.date.available2015-07-28T04:06:18Z-
dc.date.issued2010-
dc.identifier.citation2010 10th IEEE Conference on Nanotechnology, NANO 2010, 2010, p. 983-986-
dc.identifier.urihttp://hdl.handle.net/10722/213154-
dc.description.abstractElucidating the underlying mechanism of the cellular physiological activities at the molecular level is currently an important research topic in life sciences. The invention of the atomic force microscopy (AFM) provided new methods for acquiring new cognition about cellular chemical processes. With the use of AFM, the specific recognition interaction between CD20 antigen and rituximab antibody on B lymphoma cells was explored under near-physiological conditions. The high quality AFM images of B lymphoma cells were acquired and the CD20-rituximab complex binding force was measured by AFM single-molecule force spectroscopy (SMFS). The experimental results provide new insights for understanding the CD20-rituximab specific interaction and lay the foundation for the further investigation of the mechanism of rituximab. ©2010 IEEE.-
dc.languageeng-
dc.relation.ispartof2010 10th IEEE Conference on Nanotechnology, NANO 2010-
dc.titleAn experimental study on protein-protein interaction using atomic force microscopy-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1109/NANO.2010.5697849-
dc.identifier.scopuseid_2-s2.0-79951843574-
dc.identifier.spage983-
dc.identifier.epage986-

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