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Article: Increased frequency of circulating follicular helper T cells in children with hand, foot, and mouth disease caused by enterovirus 71 infection

TitleIncreased frequency of circulating follicular helper T cells in children with hand, foot, and mouth disease caused by enterovirus 71 infection
Authors
Issue Date2014
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jir/
Citation
Journal of Immunology Research, 2014, v. 2014, article no. 651872 How to Cite?
AbstractEnterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD) in children. The role of T follicular helper (TFH) cells in EV71-infected children remains unclear in regulating humoral immunity. The frequency of circulating ICOS(high)/PD-1(high)CXCR5(+)CD4(+) TFH cells in the children with mild and severe EV71 infection and healthy controls (HC) was detected by flow cytometry, respectively. IL-21 and IL-6 mRNA expression and their serum levels, Bcl-6 mRNA expression, and specific neutralizing antibodies against EV71 (NAb-EV71) were measured. In the acute stage of patients with EV71 infection, increased frequencies of circulating TFH cells with ICOS(high) and PD-1(high) expression in the mild and severe patients were observed, and the positive correlations among the frequencies of circulating TFH cells and the serum levels of IL-21, IL-6, and NAb-EV71 titres were detected, respectively. Moreover, the expressions of IL-6 and IL-21 mRNA in PBMCs from patients were also significantly higher than those of HC. However, further analysis did not reveal any significant differences between mild and severe patients. These data indicate a role of TFH cells and associated cytokines in modulating the humoral response during the pathogenesis of EV71 infection.
Persistent Identifierhttp://hdl.handle.net/10722/212121
ISSN
2015 Impact Factor: 2.812
2015 SCImago Journal Rankings: 1.346
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorWu, J-
dc.contributor.authorCui, D-
dc.contributor.authorYang, X-
dc.contributor.authorLou, J-
dc.contributor.authorLin, J-
dc.contributor.authorYe, X-
dc.contributor.authorQin, Z-
dc.contributor.authorHuang, L-
dc.contributor.authorZhao, D-
dc.contributor.authorHuo, Z-
dc.contributor.authorXie, G-
dc.contributor.authorZheng, S-
dc.contributor.authorYu, F-
dc.contributor.authorLu, L-
dc.contributor.authorChen, Y-
dc.date.accessioned2015-07-21T02:23:40Z-
dc.date.available2015-07-21T02:23:40Z-
dc.date.issued2014-
dc.identifier.citationJournal of Immunology Research, 2014, v. 2014, article no. 651872-
dc.identifier.issn2314-8861-
dc.identifier.urihttp://hdl.handle.net/10722/212121-
dc.description.abstractEnterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD) in children. The role of T follicular helper (TFH) cells in EV71-infected children remains unclear in regulating humoral immunity. The frequency of circulating ICOS(high)/PD-1(high)CXCR5(+)CD4(+) TFH cells in the children with mild and severe EV71 infection and healthy controls (HC) was detected by flow cytometry, respectively. IL-21 and IL-6 mRNA expression and their serum levels, Bcl-6 mRNA expression, and specific neutralizing antibodies against EV71 (NAb-EV71) were measured. In the acute stage of patients with EV71 infection, increased frequencies of circulating TFH cells with ICOS(high) and PD-1(high) expression in the mild and severe patients were observed, and the positive correlations among the frequencies of circulating TFH cells and the serum levels of IL-21, IL-6, and NAb-EV71 titres were detected, respectively. Moreover, the expressions of IL-6 and IL-21 mRNA in PBMCs from patients were also significantly higher than those of HC. However, further analysis did not reveal any significant differences between mild and severe patients. These data indicate a role of TFH cells and associated cytokines in modulating the humoral response during the pathogenesis of EV71 infection.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jir/-
dc.relation.ispartofJournal of Immunology Research-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleIncreased frequency of circulating follicular helper T cells in children with hand, foot, and mouth disease caused by enterovirus 71 infection-
dc.typeArticle-
dc.identifier.emailLu, L: liweilu@hkucc.hku.hk-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2014/651872-
dc.identifier.pmid25013818-
dc.identifier.pmcidPMC4071862-
dc.identifier.hkuros245004-
dc.identifier.volume2014-
dc.publisher.placeUnited States-

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