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Article: Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus

TitleRoles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus
Authors
Issue Date2015
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2015, v. 16 n. 6, p. 13084-13105 How to Cite?
AbstractToll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.
Persistent Identifierhttp://hdl.handle.net/10722/212118
ISSN
2015 Impact Factor: 3.257
2015 SCImago Journal Rankings: 1.160
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorMa, K-
dc.contributor.authorLi, J-
dc.contributor.authorFang, Y-
dc.contributor.authorLu, L-
dc.date.accessioned2015-07-21T02:23:35Z-
dc.date.available2015-07-21T02:23:35Z-
dc.date.issued2015-
dc.identifier.citationInternational Journal of Molecular Sciences, 2015, v. 16 n. 6, p. 13084-13105-
dc.identifier.issn1422-0067-
dc.identifier.urihttp://hdl.handle.net/10722/212118-
dc.description.abstractToll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleRoles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus-
dc.typeArticle-
dc.identifier.emailMa, K: kongyang@hku.hk-
dc.identifier.emailLu, L: liweilu@hkucc.hku.hk-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms160613084-
dc.identifier.pmid26068236-
dc.identifier.pmcidPMC4490487-
dc.identifier.hkuros245001-
dc.identifier.volume16-
dc.identifier.issue6-
dc.identifier.spage13084-
dc.identifier.epage13105-
dc.publisher.placeSwitzerland-

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