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Article: MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1.

TitleMicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1.
Authors
Issue Date2015
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
Journal of Immunology, 2015, v. 195 n. 3, p. 1301-1311 How to Cite?
AbstractMyeloid-derived suppressor cells (MDSCs) play a critical role in tumor-associated immunosuppression, thus affecting effective immunotherapies for cancers. However, the molecular mechanisms involved in regulating the differentiation and function of MDSCs remain largely unclear. In this study, we found that inhibition of microRNA (miR)-9 promoted the differentiation of MDSCs with significantly reduced immunosuppressive function whereas overexpression of miR-9 markedly enhanced the function of MDSCs. Notably, knockdown of miR-9 significantly impaired the activity of MDSCs and inhibited the tumor growth of Lewis lung carcinoma in mice. Moreover, miR-9 regulated MDSCs differentiation by targeting the runt-related transcription factor 1, an essential transcription factor in regulating MDSC differentiation and function. Furthermore, the CREB was found to regulate miR-9 expression in MDSCs. Taken together, our findings have identified a critical role of miR-9 in regulating the differentiation and function of MDSCs. Copyright © 2015 by The American Association of Immunologists, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/212117
ISSN
2015 Impact Factor: 4.985
2015 SCImago Journal Rankings: 3.549

 

DC FieldValueLanguage
dc.contributor.authorTian, J-
dc.contributor.authorRui, K-
dc.contributor.authorTang, X-
dc.contributor.authorMa, J-
dc.contributor.authorWang, Y-
dc.contributor.authorTian, X-
dc.contributor.authorZhang, Y-
dc.contributor.authorXu, H-
dc.contributor.authorLu, L-
dc.contributor.authorWang, S-
dc.date.accessioned2015-07-21T02:23:34Z-
dc.date.available2015-07-21T02:23:34Z-
dc.date.issued2015-
dc.identifier.citationJournal of Immunology, 2015, v. 195 n. 3, p. 1301-1311-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/212117-
dc.description.abstractMyeloid-derived suppressor cells (MDSCs) play a critical role in tumor-associated immunosuppression, thus affecting effective immunotherapies for cancers. However, the molecular mechanisms involved in regulating the differentiation and function of MDSCs remain largely unclear. In this study, we found that inhibition of microRNA (miR)-9 promoted the differentiation of MDSCs with significantly reduced immunosuppressive function whereas overexpression of miR-9 markedly enhanced the function of MDSCs. Notably, knockdown of miR-9 significantly impaired the activity of MDSCs and inhibited the tumor growth of Lewis lung carcinoma in mice. Moreover, miR-9 regulated MDSCs differentiation by targeting the runt-related transcription factor 1, an essential transcription factor in regulating MDSC differentiation and function. Furthermore, the CREB was found to regulate miR-9 expression in MDSCs. Taken together, our findings have identified a critical role of miR-9 in regulating the differentiation and function of MDSCs. Copyright © 2015 by The American Association of Immunologists, Inc.-
dc.languageeng-
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org-
dc.relation.ispartofJournal of Immunology-
dc.titleMicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1.-
dc.typeArticle-
dc.identifier.emailLu, L: liweilu@hkucc.hku.hk-
dc.identifier.authorityLu, L=rp00477-
dc.identifier.doi10.4049/jimmunol.1500209-
dc.identifier.pmid26091714-
dc.identifier.hkuros245000-
dc.identifier.volume195-
dc.identifier.issue3-
dc.identifier.spage1301-
dc.identifier.epage1311-
dc.publisher.placeUnited States-

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