File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Ficus carica Polysaccharides Promote the Maturation and Function of Dendritic Cells

TitleFicus carica Polysaccharides Promote the Maturation and Function of Dendritic Cells
Authors
Issue Date2014
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2014, v. 15 n. 7, p. 12469-12479 How to Cite?
AbstractVarious polysaccharides purified from plants are considered to be biological response modifiers and have been shown to enhance immune responses. Ficus carica L. is a Chinese traditional plant and has been widely used in Asian countries for its anti-tumor properties. Ficus carica polysaccharides (FCPS), one of the most essential and effective components in Ficus carica L., have been considered to be a beneficial immunomodulator and may be used in immunotherapy. However, the immunologic mechanism of FCPS is still unclear. Dectin-1 is a non-toll-like pattern recognition receptor, predominately expressed on dendritic cells (DCs). Activation of DCs through dectin-1 signaling can lead to the maturation of DC, thus inducing both innate and adaptive immune responses against tumor development and microbial infection. In our study, we found that FCPS could effectively stimulate DCs, partially through the dectin-1/Syk pathway, and promote their maturation, as shown by the up-regulation of CD40, CD80, CD86, and major histocompatibility complex II (MHCII). FCPS also enhanced the production of cytokines by DCs, including IL-12, IFN-γ, IL-6, and IL-23. Moreover, FCPS-treated DCs showed an enhanced capability to stimulate T cells and promote T cell proliferation. Altogether, these results demonstrate that FCPS are able to activate and maturate DCs, thereby up-regulating the immunostimulatory capacity of DCs, which leads to enhanced T cell responses.
Persistent Identifierhttp://hdl.handle.net/10722/212088
ISSN
2015 Impact Factor: 3.257
2015 SCImago Journal Rankings: 1.160
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorTian, J-
dc.contributor.authorZhang, Y-
dc.contributor.authorYang, X-
dc.contributor.authorRui, K-
dc.contributor.authorTang, X-
dc.contributor.authorMa, J-
dc.contributor.authorChen, J-
dc.contributor.authorXu, H-
dc.contributor.authorLu, L-
dc.contributor.authorWang, S-
dc.date.accessioned2015-07-21T02:22:33Z-
dc.date.available2015-07-21T02:22:33Z-
dc.date.issued2014-
dc.identifier.citationInternational Journal of Molecular Sciences, 2014, v. 15 n. 7, p. 12469-12479-
dc.identifier.issn1422-0067-
dc.identifier.urihttp://hdl.handle.net/10722/212088-
dc.description.abstractVarious polysaccharides purified from plants are considered to be biological response modifiers and have been shown to enhance immune responses. Ficus carica L. is a Chinese traditional plant and has been widely used in Asian countries for its anti-tumor properties. Ficus carica polysaccharides (FCPS), one of the most essential and effective components in Ficus carica L., have been considered to be a beneficial immunomodulator and may be used in immunotherapy. However, the immunologic mechanism of FCPS is still unclear. Dectin-1 is a non-toll-like pattern recognition receptor, predominately expressed on dendritic cells (DCs). Activation of DCs through dectin-1 signaling can lead to the maturation of DC, thus inducing both innate and adaptive immune responses against tumor development and microbial infection. In our study, we found that FCPS could effectively stimulate DCs, partially through the dectin-1/Syk pathway, and promote their maturation, as shown by the up-regulation of CD40, CD80, CD86, and major histocompatibility complex II (MHCII). FCPS also enhanced the production of cytokines by DCs, including IL-12, IFN-γ, IL-6, and IL-23. Moreover, FCPS-treated DCs showed an enhanced capability to stimulate T cells and promote T cell proliferation. Altogether, these results demonstrate that FCPS are able to activate and maturate DCs, thereby up-regulating the immunostimulatory capacity of DCs, which leads to enhanced T cell responses.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleFicus carica Polysaccharides Promote the Maturation and Function of Dendritic Cells-
dc.typeArticle-
dc.identifier.emailLu, L: liweilu@hkucc.hku.hk-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms150712469-
dc.identifier.pmid25026176-
dc.identifier.pmcidPMC4139854-
dc.identifier.hkuros244756-
dc.identifier.volume15-
dc.identifier.issue7-
dc.identifier.spage12469-
dc.identifier.epage12479-
dc.publisher.placeSwitzerland-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats