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Article: Homeobox b5(Hoxb5) regulates the expression of Forkhead box D3 gene (Foxd3) in neural crest

TitleHomeobox b5(Hoxb5) regulates the expression of Forkhead box D3 gene (Foxd3) in neural crest
Authors
Issue Date2014
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biocel
Citation
The International Journal of Biochemistry & Cell Biology, 2014, v. 55, p. 144-152 How to Cite?
AbstractPatterning of neural crest (NC) for the formation of specific structures along the anterio-posterior (A-P) body axis is governed by a combinatorial action of Hox genes, which are expressed in the neuroepithelium at the time of NC induction. Hoxb5 was expressed in NC at both induction and migratory stages, and our previous data suggested that Hoxb5 played a role in the NC development. However, the underlying mechanisms by which Hoxb5 regulates the early NC development are largely unknown. Current study showed that both the human and mouse Foxd3 promoters were bound and trans-activated by Hoxb5 in NC-derived neuroblastoma cells. The binding of Hoxb5 to Foxd3 promoter in vivo was further confirmed in the brain and neural tube of mouse embryos. Moreover, Wnt1-Cre mediated perturbation of Hoxb5 signaling at the dorsal neural tube in mouse embryos resulted in Foxd3 down-regulation. In ovo, Foxd3 alleviated the apoptosis of neural cells induced by perturbed Hoxb5 signaling, and Hoxb5 induced ectopic Foxd3 expression in the chick neural tube. This study demonstrated that Hoxb5 (an A-P patterning gene) regulated the NC development by directly inducing Foxd3 (a NC specifier and survival gene).
Persistent Identifierhttp://hdl.handle.net/10722/211610
ISSN
2015 Impact Factor: 3.905
2015 SCImago Journal Rankings: 2.003

 

DC FieldValueLanguage
dc.contributor.authorKam, MKM-
dc.contributor.authorCheung, MCH-
dc.contributor.authorZhu, JJ-
dc.contributor.authorCheng, WWC-
dc.contributor.authorSat, EWY-
dc.contributor.authorTam, PKH-
dc.contributor.authorLui, VCH-
dc.date.accessioned2015-07-21T02:04:39Z-
dc.date.available2015-07-21T02:04:39Z-
dc.date.issued2014-
dc.identifier.citationThe International Journal of Biochemistry & Cell Biology, 2014, v. 55, p. 144-152-
dc.identifier.issn1357-2725-
dc.identifier.urihttp://hdl.handle.net/10722/211610-
dc.description.abstractPatterning of neural crest (NC) for the formation of specific structures along the anterio-posterior (A-P) body axis is governed by a combinatorial action of Hox genes, which are expressed in the neuroepithelium at the time of NC induction. Hoxb5 was expressed in NC at both induction and migratory stages, and our previous data suggested that Hoxb5 played a role in the NC development. However, the underlying mechanisms by which Hoxb5 regulates the early NC development are largely unknown. Current study showed that both the human and mouse Foxd3 promoters were bound and trans-activated by Hoxb5 in NC-derived neuroblastoma cells. The binding of Hoxb5 to Foxd3 promoter in vivo was further confirmed in the brain and neural tube of mouse embryos. Moreover, Wnt1-Cre mediated perturbation of Hoxb5 signaling at the dorsal neural tube in mouse embryos resulted in Foxd3 down-regulation. In ovo, Foxd3 alleviated the apoptosis of neural cells induced by perturbed Hoxb5 signaling, and Hoxb5 induced ectopic Foxd3 expression in the chick neural tube. This study demonstrated that Hoxb5 (an A-P patterning gene) regulated the NC development by directly inducing Foxd3 (a NC specifier and survival gene).-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biocel-
dc.relation.ispartofThe International Journal of Biochemistry & Cell Biology-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in The International Journal of Biochemistry & Cell Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The International Journal of Biochemistry & Cell Biology, 2014, v. 55, p. 144-152. DOI: 10.1016/j.biocel.2014.09.002-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleHomeobox b5(Hoxb5) regulates the expression of Forkhead box D3 gene (Foxd3) in neural crest-
dc.typeArticle-
dc.identifier.emailCheung, MCH: mcheung9@hku.hk-
dc.identifier.emailSat, EWY: ericsat@HKUCC-COM.hku.hk-
dc.identifier.emailTam, PKH: paultam@hku.hk-
dc.identifier.emailLui, VCH: vchlui@hku.hk-
dc.identifier.authorityCheung, MCH=rp00245-
dc.identifier.authorityTam, PKH=rp00060-
dc.identifier.authorityLui, VCH=rp00363-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.biocel.2014.09.002-
dc.identifier.pmid25220476-
dc.identifier.scopuseid_2-s2.0-84907467471-
dc.identifier.hkuros244563-
dc.identifier.volume55-
dc.identifier.spage144-
dc.identifier.epage152-
dc.publisher.placeUnited Kingdom-

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