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Article: Intraperitoneal chemotherapy for gastric cancer with peritoneal carcinomatosis: is HIPEC the only answer?

TitleIntraperitoneal chemotherapy for gastric cancer with peritoneal carcinomatosis: is HIPEC the only answer?
Authors
Issue Date2014
PublisherScientific Research Publishing, Inc. The Journal's web site is located at http://www.scirp.org/journal/mc/
Citation
Modern Chemotherapy, 2014, v. 3 n. 2, p. 11-19 How to Cite?
AbstractGastric cancer with peritoneal carcinomatosis is notorious for its dismal prognosis. While the pathophysiology of peritoneal dissemination is still controversial, the rapid downhill course is universal. Patients usually suffer abdominal distension, intestinal obstruction and various complications before they succumb after a median of 3 - 6 months. Although not adopted in most international treatment guidelines, intraperitoneal chemotherapy has growing evidence compared with conventional systemic chemotherapy for the treatment of peritoneal carcinomatosis. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is well-established for clinical benefit but is technically demanding with substantial treatment-related morbidities and mortality. On the other hand, normothermic intraperitoneal chemotherapy in the form of bidirectional neoadjuvant treatment is promising with various newer chemotherapeutic agents. Regardless of the treatment technique applied, the essential element of success is meticulous patient selection and availability of expertise. Future direction is along the line of personalized treatment with the application of translational science.
Persistent Identifierhttp://hdl.handle.net/10722/209298
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLam, KOen_US
dc.contributor.authorLaw, BTTen_US
dc.contributor.authorLaw, SYKen_US
dc.contributor.authorKwong, DLWen_US
dc.date.accessioned2015-04-17T05:04:47Z-
dc.date.available2015-04-17T05:04:47Z-
dc.date.issued2014en_US
dc.identifier.citationModern Chemotherapy, 2014, v. 3 n. 2, p. 11-19en_US
dc.identifier.issn2169-348Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/209298-
dc.description.abstractGastric cancer with peritoneal carcinomatosis is notorious for its dismal prognosis. While the pathophysiology of peritoneal dissemination is still controversial, the rapid downhill course is universal. Patients usually suffer abdominal distension, intestinal obstruction and various complications before they succumb after a median of 3 - 6 months. Although not adopted in most international treatment guidelines, intraperitoneal chemotherapy has growing evidence compared with conventional systemic chemotherapy for the treatment of peritoneal carcinomatosis. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is well-established for clinical benefit but is technically demanding with substantial treatment-related morbidities and mortality. On the other hand, normothermic intraperitoneal chemotherapy in the form of bidirectional neoadjuvant treatment is promising with various newer chemotherapeutic agents. Regardless of the treatment technique applied, the essential element of success is meticulous patient selection and availability of expertise. Future direction is along the line of personalized treatment with the application of translational science.en_US
dc.languageengen_US
dc.publisherScientific Research Publishing, Inc. The Journal's web site is located at http://www.scirp.org/journal/mc/en_US
dc.relation.ispartofModern Chemotherapyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleIntraperitoneal chemotherapy for gastric cancer with peritoneal carcinomatosis: is HIPEC the only answer?en_US
dc.typeArticleen_US
dc.identifier.emailLam, KO: lamkaon@hku.hken_US
dc.identifier.emailLaw, SYK: slaw@hkucc.hku.hken_US
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_US
dc.identifier.authorityLam, KO=rp01501en_US
dc.identifier.authorityLaw, SYK=rp00437en_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4236/mc.2014.32003en_US
dc.identifier.hkuros242829en_US
dc.identifier.volume3en_US
dc.identifier.issue2en_US
dc.identifier.spage11en_US
dc.identifier.epage19en_US
dc.publisher.placeUnited Statesen_US

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