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Article: The Role of Electrical Stimulation Therapy in Ophthalmic Diseases

TitleThe Role of Electrical Stimulation Therapy in Ophthalmic Diseases
Authors
Issue Date2015
Citation
Graefe's Archive for Clinical and Experimental Ophthalmology, 2015, v. 253 n. 2, p. 171-176 How to Cite?
AbstractIntroduction: Electrical stimulation therapy (EST) involves the use of low-intensity electrical current in treatment of neuromuscular conditions. In the recent two decades, EST has emerged as a potential neuro-protective strategy in certain ophthalmic diseases, aided by a lack of effective management for these conditions. Purpose: The aim of this review is to summarize and discuss current available evidence for the use of EST in ophthalmic diseases in the laboratory setting and in human trials. Methods: The compilation and review of published English-language reports on the use of EST in human ophthalmic disease and animal models of ophthalmic disease. . Results: From published reports, research work on the use of EST in ophthalmic diseases began in the last twenty years. Different methods of electrical stimulation have been devised, with varying levels of invasiveness. Results from human trials have favored earlier and repeated treatment after insults to the optic nerve, while EST has shown transient effectiveness in degenerative diseases of photoreceptors. Patients also reported no serious adverse effects from EST in the clinical trials. Results from animal studies have further confirmed survival benefits of EST in retinal cell survival, with the underlying mechanism likely multifactorial, but involving Müller cell modulation. Conclusions: Results from human and animal studies have demonstrated the relevance and potential effectiveness of EST in ophthalmic disease. However, optimal disease and species-specific stimulation settings need to be defined.
Persistent Identifierhttp://hdl.handle.net/10722/207463

 

DC FieldValueLanguage
dc.contributor.authorFU, Len_US
dc.contributor.authorLo, ACYen_US
dc.contributor.authorLai, JSMen_US
dc.contributor.authorShih, KCen_US
dc.date.accessioned2014-12-19T13:22:13Z-
dc.date.available2014-12-19T13:22:13Z-
dc.date.issued2015-
dc.identifier.citationGraefe's Archive for Clinical and Experimental Ophthalmology, 2015, v. 253 n. 2, p. 171-176en_US
dc.identifier.urihttp://hdl.handle.net/10722/207463-
dc.description.abstractIntroduction: Electrical stimulation therapy (EST) involves the use of low-intensity electrical current in treatment of neuromuscular conditions. In the recent two decades, EST has emerged as a potential neuro-protective strategy in certain ophthalmic diseases, aided by a lack of effective management for these conditions. Purpose: The aim of this review is to summarize and discuss current available evidence for the use of EST in ophthalmic diseases in the laboratory setting and in human trials. Methods: The compilation and review of published English-language reports on the use of EST in human ophthalmic disease and animal models of ophthalmic disease. . Results: From published reports, research work on the use of EST in ophthalmic diseases began in the last twenty years. Different methods of electrical stimulation have been devised, with varying levels of invasiveness. Results from human trials have favored earlier and repeated treatment after insults to the optic nerve, while EST has shown transient effectiveness in degenerative diseases of photoreceptors. Patients also reported no serious adverse effects from EST in the clinical trials. Results from animal studies have further confirmed survival benefits of EST in retinal cell survival, with the underlying mechanism likely multifactorial, but involving Müller cell modulation. Conclusions: Results from human and animal studies have demonstrated the relevance and potential effectiveness of EST in ophthalmic disease. However, optimal disease and species-specific stimulation settings need to be defined.en_US
dc.languageengen_US
dc.relation.ispartofGraefe's Archive for Clinical and Experimental Ophthalmologyen_US
dc.titleThe Role of Electrical Stimulation Therapy in Ophthalmic Diseasesen_US
dc.typeArticleen_US
dc.identifier.emailLo, ACY: amylo@hku.hken_US
dc.identifier.emailLai, JSM: laism@hku.hken_US
dc.identifier.emailShih, KC: kcshih@hku.hken_US
dc.identifier.authorityLo, ACY=rp00425en_US
dc.identifier.authorityLai, JSM=rp00295en_US
dc.identifier.authorityShih, KC=rp01374en_US
dc.identifier.doi10.1007/s00417-014-2889-7-
dc.identifier.hkuros241718en_US

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