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Article: Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma

TitleClinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma
Authors
Issue Date2014
PublisherImpact Journals LLC. The Journal's web site is located at http://www.impactjournals.com/oncotarget/index.html
Citation
Oncotarget, 2014, v. 5 n. 22, p. 11103-11120 How to Cite?
AbstractAIMS: We aimed to investigate the clinical significance of GPx3 in hepatocellular carcinoma (HCC) and to characterize its tumor suppressive role. METHODS: HCC patients (113) who underwent hepatectomy were recruited to examine the clinical relevance of GPx3. The tumor suppressive role of GPx3 was studied by administration of recombinant GPx3 (rGPx3) or over-expression of GPx3 in HCC cells in vitro and in vivo. The therapeutic value of GPx3 for HCC was further investigated using human induced pluripotent stem cell derived mesenchymal stem cells (hiPSC-MSCs) as its delivery vehicle. RESULTS: Down-regulation of GPx3 significantly correlated with advanced tumor stage (P = 0.024), venous infiltration (P = 0.043) and poor overall survival (P = 0.007) after hepatectomy. Lower plasma GPx3 in HCC patients was significantly associated with larger tumor size (P = 0.011), more tumor nodules (P = 0.032) and higher recurrence (P = 0.016). Over-expression of GPx3 or administration of rGPx3 significantly inhibited proliferation and invasiveness of HCC cells in vitro and in vivo. Tumor suppressive activity of GPx3 was mediated through Erk-NFκB-SIP1 pathway. GPx3 could be delivered by hiPSC-MSCs into the tumor and exhibited tumor suppressive activity in vivo. CONCLUSIONS: GPx3 is a tumor suppressor gene in HCC and may possess prognostic and therapeutic value for HCC patients.
Persistent Identifierhttp://hdl.handle.net/10722/207252
ISSN
2015 Impact Factor: 5.008
2015 SCImago Journal Rankings: 2.294
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorQi, X-
dc.contributor.authorNg, KTP-
dc.contributor.authorLian, QZ-
dc.contributor.authorLiu, XB-
dc.contributor.authorLi, CX-
dc.contributor.authorGeng, W-
dc.contributor.authorLing, CC-
dc.contributor.authorMa, YY-
dc.contributor.authorYeung, WH-
dc.contributor.authorTu, W-
dc.contributor.authorFan, ST-
dc.contributor.authorLo, CM-
dc.contributor.authorMan, K-
dc.date.accessioned2014-12-19T09:35:40Z-
dc.date.available2014-12-19T09:35:40Z-
dc.date.issued2014-
dc.identifier.citationOncotarget, 2014, v. 5 n. 22, p. 11103-11120-
dc.identifier.issn1949-2553-
dc.identifier.urihttp://hdl.handle.net/10722/207252-
dc.description.abstractAIMS: We aimed to investigate the clinical significance of GPx3 in hepatocellular carcinoma (HCC) and to characterize its tumor suppressive role. METHODS: HCC patients (113) who underwent hepatectomy were recruited to examine the clinical relevance of GPx3. The tumor suppressive role of GPx3 was studied by administration of recombinant GPx3 (rGPx3) or over-expression of GPx3 in HCC cells in vitro and in vivo. The therapeutic value of GPx3 for HCC was further investigated using human induced pluripotent stem cell derived mesenchymal stem cells (hiPSC-MSCs) as its delivery vehicle. RESULTS: Down-regulation of GPx3 significantly correlated with advanced tumor stage (P = 0.024), venous infiltration (P = 0.043) and poor overall survival (P = 0.007) after hepatectomy. Lower plasma GPx3 in HCC patients was significantly associated with larger tumor size (P = 0.011), more tumor nodules (P = 0.032) and higher recurrence (P = 0.016). Over-expression of GPx3 or administration of rGPx3 significantly inhibited proliferation and invasiveness of HCC cells in vitro and in vivo. Tumor suppressive activity of GPx3 was mediated through Erk-NFκB-SIP1 pathway. GPx3 could be delivered by hiPSC-MSCs into the tumor and exhibited tumor suppressive activity in vivo. CONCLUSIONS: GPx3 is a tumor suppressor gene in HCC and may possess prognostic and therapeutic value for HCC patients.-
dc.languageeng-
dc.publisherImpact Journals LLC. The Journal's web site is located at http://www.impactjournals.com/oncotarget/index.html-
dc.relation.ispartofOncotarget-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleClinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma-
dc.typeArticle-
dc.identifier.emailQi, X: qixiang515@connect.hku.hk-
dc.identifier.emailNg, KTP: ledodes@hku.hk-
dc.identifier.emailLian, QZ: qzlian@hkucc.hku.hk-
dc.identifier.emailLiu, XB: liuxb301@hku.hk-
dc.identifier.emailLi, CX: doclicx@hku.hk-
dc.identifier.emailGeng, W: weigeng@hku.hk-
dc.identifier.emailLing, CC: lingccl@hku.hk-
dc.identifier.emailMa, YY: yyma@hku.hk-
dc.identifier.emailYeung, WH: why21@hku.hk-
dc.identifier.emailTu, W: wwtu@hku.hk-
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailMan, K: kwanman@hku.hk-
dc.identifier.authorityNg, KTP=rp01720en_US
dc.identifier.authorityLian, Q=rp00267en_US
dc.identifier.authorityTu, W=rp00416en_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.identifier.authorityMan, K=rp00417en_US
dc.description.naturepublished_or_final_version-
dc.identifier.pmid25333265-
dc.identifier.pmcidPMC4294380-
dc.identifier.hkuros241969-
dc.identifier.volume5-
dc.identifier.issue22-
dc.identifier.spage11103-
dc.identifier.epage11120-
dc.publisher.placeUnited States-

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