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Article: Coupling physical exercise with dietary glucose supplement for treating cognitive impairment in schizophrenia: A theoretical model and future directions

TitleCoupling physical exercise with dietary glucose supplement for treating cognitive impairment in schizophrenia: A theoretical model and future directions
Authors
KeywordsCognitive impairment
Exercise
Schizophrenia
Glucose supplement
Issue Date2014
Citation
Early Intervention in Psychiatry, 2014, v. 8, n. 3, p. 209-220 How to Cite?
AbstractAims: Metabolic dysregulation may disrupt the complex neuroprotective mechanisms essential for brain health. Recent studies have pointed out the possible aetiological role of metabolic dysregulation in the onset of schizophrenia and the associated cognitive impairment. In this paper, we aimed to generate a theoretical model of how a combination of physical exercise and dietary glucose supplement may help to alleviate cognitive impairment in schizophrenia. Methods: Literature on metabolic dysregulation, especially insulin resistance, in relation to the onset of schizophrenia and the associated cognitive impairment is reviewed. The cognitive enhancement effects of physical exercise and dietary glucose supplement are then summarised. Finally, we propose a theoretical model based on the concerted effects of physical exercise and glucose supplement. Results: In general, the joint action of physical exercise and dietary glucose supplement could up-regulate glucose and insulin transport into the brain, as well as augmenting the release of insulin growth factor-1 and brain-derived neurotrophic factor. Physical exercise and glucose supplement could enhance energy supply and neuroplasticity in brain, subsequently leading to potential cognitive enhancement in schizophrenia. However, glucose supplement is not suitable for patients with abnormal metabolic profile. Conclusions: The combination of physical exercise and glucose supplement has potential therapeutic values in treating cognitive impairment in schizophrenia. Further research is necessary to investigate the optimal patterns of exercise and doses of glucose for treating cognitive impairment in schizophrenia. © 2013 Wiley Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/207095
ISSN
2015 Impact Factor: 2.889
2015 SCImago Journal Rankings: 1.071

 

DC FieldValueLanguage
dc.contributor.authorLi, Yuetkeung-
dc.contributor.authorHui, Christylai-
dc.contributor.authorLee, Edwin-
dc.contributor.authorChang, Wing Chung-
dc.contributor.authorChan, Sherry Kit Wa-
dc.contributor.authorLeung, Chungming-
dc.contributor.authorChen, Eric Y H-
dc.date.accessioned2014-12-09T04:31:23Z-
dc.date.available2014-12-09T04:31:23Z-
dc.date.issued2014-
dc.identifier.citationEarly Intervention in Psychiatry, 2014, v. 8, n. 3, p. 209-220-
dc.identifier.issn1751-7885-
dc.identifier.urihttp://hdl.handle.net/10722/207095-
dc.description.abstractAims: Metabolic dysregulation may disrupt the complex neuroprotective mechanisms essential for brain health. Recent studies have pointed out the possible aetiological role of metabolic dysregulation in the onset of schizophrenia and the associated cognitive impairment. In this paper, we aimed to generate a theoretical model of how a combination of physical exercise and dietary glucose supplement may help to alleviate cognitive impairment in schizophrenia. Methods: Literature on metabolic dysregulation, especially insulin resistance, in relation to the onset of schizophrenia and the associated cognitive impairment is reviewed. The cognitive enhancement effects of physical exercise and dietary glucose supplement are then summarised. Finally, we propose a theoretical model based on the concerted effects of physical exercise and glucose supplement. Results: In general, the joint action of physical exercise and dietary glucose supplement could up-regulate glucose and insulin transport into the brain, as well as augmenting the release of insulin growth factor-1 and brain-derived neurotrophic factor. Physical exercise and glucose supplement could enhance energy supply and neuroplasticity in brain, subsequently leading to potential cognitive enhancement in schizophrenia. However, glucose supplement is not suitable for patients with abnormal metabolic profile. Conclusions: The combination of physical exercise and glucose supplement has potential therapeutic values in treating cognitive impairment in schizophrenia. Further research is necessary to investigate the optimal patterns of exercise and doses of glucose for treating cognitive impairment in schizophrenia. © 2013 Wiley Publishing Asia Pty Ltd.-
dc.languageeng-
dc.relation.ispartofEarly Intervention in Psychiatry-
dc.subjectCognitive impairment-
dc.subjectExercise-
dc.subjectSchizophrenia-
dc.subjectGlucose supplement-
dc.titleCoupling physical exercise with dietary glucose supplement for treating cognitive impairment in schizophrenia: A theoretical model and future directions-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/eip.12109-
dc.identifier.scopuseid_2-s2.0-84904756814-
dc.identifier.hkuros235624-
dc.identifier.hkuros229228-
dc.identifier.volume8-
dc.identifier.issue3-
dc.identifier.spage209-
dc.identifier.epage220-
dc.identifier.eissn1751-7893-

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