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Article: Early Bilateral Amniotic Membrane Transplantation in the Management of Severe Ocular Involvement from Acute Toxic Epidermal Necrolysis in a Chinese Pediatric Patient

TitleEarly Bilateral Amniotic Membrane Transplantation in the Management of Severe Ocular Involvement from Acute Toxic Epidermal Necrolysis in a Chinese Pediatric Patient
Authors
Issue Date2014
Citation
Journal of Clinical and Experimental Ophthalmology, 2014, v. 5 n. 4, article no. 1000358 How to Cite?
AbstractIntroduction: Toxic Epidermal Necrolysis (TEN) is a rare but potentially life-threatening muco-cutaneous condition associated with idiosyncratic hypersensitivity to certain drugs. Ophthalmic involvement is common, typically affecting the ocular surface and eyelids. Survivors often suffer from resulting bilateral blindness and ocular dryness or pain. Objective: To report the successful management of severe ocular surface disease during the acute stage of toxic epidermal necrolysis using early amniotic membrane transplantation on both eyes in a Chinese paediatric patient. Design: Interventional case report Case Report: A 15 year-old Chinese girl was transferred to the intensive care unit of Queen Mary Hospital, Hong Kong with TEN after taking oral cefuroxime and diclofenac. She developed bilateral keratoconjunctivitis, diffuse corneal epithelial defects (80-90% of cornea surface) and later bilateral symblephara. After initial treatment with daily rodding, topical lubricants, steroids and antibiotics, there was no improvement in her condition. Bilateral amniotic membrane transplantation (AMT) was performed over the cornea, fornix, tarsal and bulbar conjunctiva on day 10 of illness. On discharge from the hospital (post-operative week 7), the patient had pinhole visual acuity of 6/7.5 in the right eye and 6/6 the left eye. She was eventually weaned off all topical medication. Visual acuity eventually recovered to 6/6 in both eyes by week 20 after surgery. There was mild residual forniceal symblepharon and eyelid margin keratinization. She continues to require regular lubricants for her chronic ocular surface condition.
Persistent Identifierhttp://hdl.handle.net/10722/206187

 

DC FieldValueLanguage
dc.contributor.authorShih, KCen_US
dc.contributor.authorYim, SMen_US
dc.contributor.authorChan, CYJen_US
dc.contributor.authorChan, KSKen_US
dc.contributor.authorLai, JSMen_US
dc.contributor.authorYuen, LHen_US
dc.date.accessioned2014-10-20T14:00:59Z-
dc.date.available2014-10-20T14:00:59Z-
dc.date.issued2014en_US
dc.identifier.citationJournal of Clinical and Experimental Ophthalmology, 2014, v. 5 n. 4, article no. 1000358en_US
dc.identifier.urihttp://hdl.handle.net/10722/206187-
dc.description.abstractIntroduction: Toxic Epidermal Necrolysis (TEN) is a rare but potentially life-threatening muco-cutaneous condition associated with idiosyncratic hypersensitivity to certain drugs. Ophthalmic involvement is common, typically affecting the ocular surface and eyelids. Survivors often suffer from resulting bilateral blindness and ocular dryness or pain. Objective: To report the successful management of severe ocular surface disease during the acute stage of toxic epidermal necrolysis using early amniotic membrane transplantation on both eyes in a Chinese paediatric patient. Design: Interventional case report Case Report: A 15 year-old Chinese girl was transferred to the intensive care unit of Queen Mary Hospital, Hong Kong with TEN after taking oral cefuroxime and diclofenac. She developed bilateral keratoconjunctivitis, diffuse corneal epithelial defects (80-90% of cornea surface) and later bilateral symblephara. After initial treatment with daily rodding, topical lubricants, steroids and antibiotics, there was no improvement in her condition. Bilateral amniotic membrane transplantation (AMT) was performed over the cornea, fornix, tarsal and bulbar conjunctiva on day 10 of illness. On discharge from the hospital (post-operative week 7), the patient had pinhole visual acuity of 6/7.5 in the right eye and 6/6 the left eye. She was eventually weaned off all topical medication. Visual acuity eventually recovered to 6/6 in both eyes by week 20 after surgery. There was mild residual forniceal symblepharon and eyelid margin keratinization. She continues to require regular lubricants for her chronic ocular surface condition.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Clinical and Experimental Ophthalmologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleEarly Bilateral Amniotic Membrane Transplantation in the Management of Severe Ocular Involvement from Acute Toxic Epidermal Necrolysis in a Chinese Pediatric Patienten_US
dc.typeArticleen_US
dc.identifier.emailShih, KC: kcshih@hku.hken_US
dc.identifier.emailYim, SM: smyim@hkucc.hku.hken_US
dc.identifier.emailChan, CYJ: chanjc@hku.hken_US
dc.identifier.emailChan, KSK: keith1@hkucc.hku.hken_US
dc.identifier.emailLai, JSM: laism@hku.hken_US
dc.identifier.emailYuen, LH: lhyuen@hku.hken_US
dc.identifier.authorityShih, KC=rp01374en_US
dc.identifier.authorityChan, CYJ=rp01737en_US
dc.identifier.authorityLai, JSM=rp00295en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4172/2155-9570.1000358-
dc.identifier.hkuros241242en_US

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