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Article: Quantitative assessment of column-specific degeneration in cervical spondylotic myelopathy based on diffusion tensor tractography

TitleQuantitative assessment of column-specific degeneration in cervical spondylotic myelopathy based on diffusion tensor tractography
Authors
KeywordsDiffusion tensor imaging
Cervical spondylotic myelopathy
Fractional anisotropy
Tractography
Spinal cord
Issue Date2015
PublisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586
Citation
European Spine Journal, 2015, v. 24 n. 1, p. 41-47 How to Cite?
AbstractPurpose Cervical spondylotic myelopathy (CSM) is a common spinal cord disorder in the elderly. Diffusion tensor imaging (DTI) has been shown to be of great value for evaluating the microstructure of nerve tracts in the spinal cord. Currently, the quantitative assessment of the degeneration on the specific tracts in CSM is still rare. The aim of the present study was to use tractography-based quantification to investigate the column-specific degeneration in CSM. Methods A total of 43 volunteers were recruited with written informed consent, including 20 healthy subjects and 23 CSM patients. Diffusion MRI was taken by 3T MRI scanner. Fiber tractography was performed using TrackVis to reconstruct the white matter tracts of the anterior, lateral and posterior column on the bilateral sides. The DTI metrics acquired from tractography, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), were compared between healthy subjects and CSM patients. Results Compared to healthy subjects, FA was found significantly lower in the lateral (Healthy 0.64 ± 0.07 vs. CSM 0.53 ± 0.08) and posterior column (Healthy 0.67 ± 0.08 vs. CSM 0.47 ± 0.08) (p < 0.001), while MD, AD and RD were significantly higher in the anterior, lateral and posterior column in CSM (p < 0.05). Conclusion Loss of microstructural integrity was detected in the lateral and posterior column in CSM. Tractography-based quantification was capable of evaluating the subtle pathological insult within white matter on a column-specific basis, which exhibited potential clinical value for in vivo evaluation of the severity of CSM. © 2014 Springer-Verlag Berlin Heidelberg.
Persistent Identifierhttp://hdl.handle.net/10722/205816
ISSN
2015 Impact Factor: 2.132
2015 SCImago Journal Rankings: 0.972

 

DC FieldValueLanguage
dc.contributor.authorCui, Jiaolong-
dc.contributor.authorLi, Xiang-
dc.contributor.authorChan, Tinyan-
dc.contributor.authorMak, Kincheung-
dc.contributor.authorLuk, Keith Dip Kei-
dc.contributor.authorHu, Yong-
dc.date.accessioned2014-10-06T08:02:24Z-
dc.date.available2014-10-06T08:02:24Z-
dc.date.issued2015-
dc.identifier.citationEuropean Spine Journal, 2015, v. 24 n. 1, p. 41-47-
dc.identifier.issn0940-6719-
dc.identifier.urihttp://hdl.handle.net/10722/205816-
dc.description.abstractPurpose Cervical spondylotic myelopathy (CSM) is a common spinal cord disorder in the elderly. Diffusion tensor imaging (DTI) has been shown to be of great value for evaluating the microstructure of nerve tracts in the spinal cord. Currently, the quantitative assessment of the degeneration on the specific tracts in CSM is still rare. The aim of the present study was to use tractography-based quantification to investigate the column-specific degeneration in CSM. Methods A total of 43 volunteers were recruited with written informed consent, including 20 healthy subjects and 23 CSM patients. Diffusion MRI was taken by 3T MRI scanner. Fiber tractography was performed using TrackVis to reconstruct the white matter tracts of the anterior, lateral and posterior column on the bilateral sides. The DTI metrics acquired from tractography, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD), were compared between healthy subjects and CSM patients. Results Compared to healthy subjects, FA was found significantly lower in the lateral (Healthy 0.64 ± 0.07 vs. CSM 0.53 ± 0.08) and posterior column (Healthy 0.67 ± 0.08 vs. CSM 0.47 ± 0.08) (p < 0.001), while MD, AD and RD were significantly higher in the anterior, lateral and posterior column in CSM (p < 0.05). Conclusion Loss of microstructural integrity was detected in the lateral and posterior column in CSM. Tractography-based quantification was capable of evaluating the subtle pathological insult within white matter on a column-specific basis, which exhibited potential clinical value for in vivo evaluation of the severity of CSM. © 2014 Springer-Verlag Berlin Heidelberg.-
dc.languageeng-
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586-
dc.relation.ispartofEuropean Spine Journal-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/s00586-014-3522-5-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectDiffusion tensor imaging-
dc.subjectCervical spondylotic myelopathy-
dc.subjectFractional anisotropy-
dc.subjectTractography-
dc.subjectSpinal cord-
dc.titleQuantitative assessment of column-specific degeneration in cervical spondylotic myelopathy based on diffusion tensor tractography-
dc.typeArticle-
dc.description.naturepostprint-
dc.identifier.doi10.1007/s00586-014-3522-5-
dc.identifier.pmid25150714-
dc.identifier.scopuseid_2-s2.0-84921059347-
dc.identifier.hkuros246626-
dc.identifier.hkuros249917-
dc.identifier.eissn1432-0932-
dc.publisher.placeGermany-

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