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Conference Paper: The role of RAP1 in graft injury induced cisplatin resistance after liver transplantation
Title | The role of RAP1 in graft injury induced cisplatin resistance after liver transplantation |
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Authors | |
Keywords | Medical sciences Gastroenterology medical sciences Surgery |
Issue Date | 2014 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021 |
Citation | The 2014 Joint International Congress of ILTS, ELITA and LICAGE, London, UK., 4-7 June 2014. In Liver Transplantation, 2014, v. 20 suppl. S1, p. S257, abstract P-343 How to Cite? |
Abstract | BACKGROUND & AIM: Liver transplantation dramatically improved the survival rate of HCC patients. However, tumor recurrence remains a huge threat without any promising curative treatment. We aim to clarify the mechanism of graft injury regulating chemoresistance after liver transplantation. MATERIALS AND METHODS: A rat orthotopic liver transplantation model with liver cancer development was established with applying whole or small-for-size (50%) graft. The expressions of multidrug resistant genes and RAP1 were compared between small and whole graft groups. RAP1 expression was also validated in clinical samples. The role of RAP1 was further explored in vitro and vivo. RESULTS: The expression of RAP1 was constantly higher in liver and tumor in small-for-size group in rat liver transplantation model. (see diagrams) CONCLUSIONS: Overexpression of intragraft RAP1, which upregulated by acute phase liver graft injury, may induce late phase cisplatin resistance after liver transplantation. |
Description | Poster Session 2: P-343 This journal suppl. entitled: The ILTS 20th Annual International Congress |
Persistent Identifier | http://hdl.handle.net/10722/204489 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 1.700 |
DC Field | Value | Language |
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dc.contributor.author | Geng, W | - |
dc.contributor.author | Lo, CM | - |
dc.contributor.author | Qi, X | - |
dc.contributor.author | Li, C | - |
dc.contributor.author | Ng, KTP | - |
dc.contributor.author | Liu, X | - |
dc.contributor.author | Ma, YY | - |
dc.contributor.author | Man, K | - |
dc.date.accessioned | 2014-09-19T23:57:02Z | - |
dc.date.available | 2014-09-19T23:57:02Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | The 2014 Joint International Congress of ILTS, ELITA and LICAGE, London, UK., 4-7 June 2014. In Liver Transplantation, 2014, v. 20 suppl. S1, p. S257, abstract P-343 | - |
dc.identifier.issn | 1527-6465 | - |
dc.identifier.uri | http://hdl.handle.net/10722/204489 | - |
dc.description | Poster Session 2: P-343 | - |
dc.description | This journal suppl. entitled: The ILTS 20th Annual International Congress | - |
dc.description.abstract | BACKGROUND & AIM: Liver transplantation dramatically improved the survival rate of HCC patients. However, tumor recurrence remains a huge threat without any promising curative treatment. We aim to clarify the mechanism of graft injury regulating chemoresistance after liver transplantation. MATERIALS AND METHODS: A rat orthotopic liver transplantation model with liver cancer development was established with applying whole or small-for-size (50%) graft. The expressions of multidrug resistant genes and RAP1 were compared between small and whole graft groups. RAP1 expression was also validated in clinical samples. The role of RAP1 was further explored in vitro and vivo. RESULTS: The expression of RAP1 was constantly higher in liver and tumor in small-for-size group in rat liver transplantation model. (see diagrams) CONCLUSIONS: Overexpression of intragraft RAP1, which upregulated by acute phase liver graft injury, may induce late phase cisplatin resistance after liver transplantation. | - |
dc.language | eng | - |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021 | - |
dc.relation.ispartof | Liver Transplantation | - |
dc.rights | Liver Transplantation. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | Medical sciences | - |
dc.subject | Gastroenterology medical sciences | - |
dc.subject | Surgery | - |
dc.title | The role of RAP1 in graft injury induced cisplatin resistance after liver transplantation | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Geng, W: weigeng@hku.hk | - |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | - |
dc.identifier.email | Qi, X: qixiang515@connect.hku.hk | - |
dc.identifier.email | Li, C: doclicx@hku.hk | - |
dc.identifier.email | Ng, KTP: ledodes@hku.hk | - |
dc.identifier.email | Liu, X: liuxb301@hku.hk | - |
dc.identifier.email | Ma, YY: yyma@hku.hk | - |
dc.identifier.email | Man, K: kwanman@hku.hk | - |
dc.identifier.authority | Lo, CM=rp00412 | - |
dc.identifier.authority | Ng, KTP=rp01720 | - |
dc.identifier.authority | Man, K=rp00417 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/lt.23901 | - |
dc.identifier.scopus | eid_2-s2.0-84932186609 | - |
dc.identifier.hkuros | 237555 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | suppl. S1 | - |
dc.identifier.spage | S257, abstract P-343 | - |
dc.identifier.epage | S257, abstract P-343 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1527-6465 | - |