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Conference Paper: Stroke patients with cancer are at increased risk of recurrent stroke and cardiovascular mortality

TitleStroke patients with cancer are at increased risk of recurrent stroke and cardiovascular mortality
Authors
Issue Date2014
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 19th Medical Research Conference (MRC 2014), Hong Kong, China, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 suppl. 1, p. 29, abstract no. 42 How to Cite?
AbstractBackground: Cancer patients are at increased risk of cardiovascular and cerebrovascular events. It is unclear whether cancer confers any additional risk for recurrent stroke or cardiovascular mortality after stroke. Methods: This was a single-centre, observational study of 1105 consecutive Chinese ischaemic stroke patients recruited from a large stroke rehabilitation unit based in Hong Kong. We sought to determine whether patients with cancer are at higher risk of recurrent stroke and cardiovascular mortality. Results: Among 1105 patients, 58 patients (5.2%) had cancer, of whom 74% were in remission. After a mean follow-up of 76 ± 18 months, 241 patients developed a recurrent stroke: 22 in patients with cancer (38%, annual incidence, 13.94%/year), substantially more than those without cancer (21%, 4.65%/year) [P < 0.01]. In a Cox regression model, cancer, age, and atrial fibrillation were the three independent predictors of recurrent stroke with a hazard ratio (HR) of 2.42 (95% confidence interval [CI], 1.54-3.80), 1.01 (1.00-1.03), and 1.35 (1.01-1.82), respectively. Likewise, patients with cancer had a higher cardiovascular mortality compared with those without cancer (4.30%/year vs 2.35%/year; P = 0.08). In Cox regression analysis, cancer (HR = 2.08; 95% CI, 1.08-4.02), age (HR = 1.04; 95% CI, 1.02-1.06), heart failure (HR = 3.07; 95% CI, 1.72-5.47), and significant carotid atherosclerosis (HR = 1.55; 95% CI, 1.02-2.36) were independent predictors for cardiovascular mortality. Conclusions: Cancer patients who develop ischaemic stroke are at increased risk of recurrent stroke and cardiovascular mortality.
Persistent Identifierhttp://hdl.handle.net/10722/204269
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLau, GKKen_US
dc.contributor.authorWong, YKen_US
dc.contributor.authorTeo, KCen_US
dc.contributor.authorChang, RSKen_US
dc.contributor.authorHon, FKSen_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorCheung, RTFen_US
dc.contributor.authorLi, LSWen_US
dc.contributor.authorTse, HFen_US
dc.contributor.authorHo, SLen_US
dc.contributor.authorSiu, DCWen_US
dc.date.accessioned2014-09-19T21:43:13Z-
dc.date.available2014-09-19T21:43:13Z-
dc.date.issued2014en_US
dc.identifier.citationThe 19th Medical Research Conference (MRC 2014), Hong Kong, China, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 suppl. 1, p. 29, abstract no. 42en_US
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/204269-
dc.description.abstractBackground: Cancer patients are at increased risk of cardiovascular and cerebrovascular events. It is unclear whether cancer confers any additional risk for recurrent stroke or cardiovascular mortality after stroke. Methods: This was a single-centre, observational study of 1105 consecutive Chinese ischaemic stroke patients recruited from a large stroke rehabilitation unit based in Hong Kong. We sought to determine whether patients with cancer are at higher risk of recurrent stroke and cardiovascular mortality. Results: Among 1105 patients, 58 patients (5.2%) had cancer, of whom 74% were in remission. After a mean follow-up of 76 ± 18 months, 241 patients developed a recurrent stroke: 22 in patients with cancer (38%, annual incidence, 13.94%/year), substantially more than those without cancer (21%, 4.65%/year) [P < 0.01]. In a Cox regression model, cancer, age, and atrial fibrillation were the three independent predictors of recurrent stroke with a hazard ratio (HR) of 2.42 (95% confidence interval [CI], 1.54-3.80), 1.01 (1.00-1.03), and 1.35 (1.01-1.82), respectively. Likewise, patients with cancer had a higher cardiovascular mortality compared with those without cancer (4.30%/year vs 2.35%/year; P = 0.08). In Cox regression analysis, cancer (HR = 2.08; 95% CI, 1.08-4.02), age (HR = 1.04; 95% CI, 1.02-1.06), heart failure (HR = 3.07; 95% CI, 1.72-5.47), and significant carotid atherosclerosis (HR = 1.55; 95% CI, 1.02-2.36) were independent predictors for cardiovascular mortality. Conclusions: Cancer patients who develop ischaemic stroke are at increased risk of recurrent stroke and cardiovascular mortality.-
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journalen_US
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleStroke patients with cancer are at increased risk of recurrent stroke and cardiovascular mortalityen_US
dc.typeConference_Paperen_US
dc.identifier.emailLau, GKK: gkklau@hku.hken_US
dc.identifier.emailChan, KH: koonho@hku.hken_US
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_US
dc.identifier.emailLi, LSW: lswli@hkucc.hku.hken_US
dc.identifier.emailTse, HF: hftse@hkucc.hku.hken_US
dc.identifier.emailHo, SL: slho@hku.hken_US
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hken_US
dc.identifier.authorityLau, GKK=rp01499en_US
dc.identifier.authorityChan, KH=rp00537en_US
dc.identifier.authorityCheung, RTF=rp00434en_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.identifier.authorityHo, SL=rp00240en_US
dc.identifier.authoritySiu, DCW=rp00534en_US
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros236266en_US
dc.identifier.volume20en_US
dc.identifier.issuesuppl. 1en_US
dc.identifier.spage29, abstract no. 42en_US
dc.identifier.epage29, abstract no. 42en_US
dc.publisher.placeHong Kong-

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